2024
First episode psychoses in people over-35 years old: uncovering potential actionable targets for early intervention services
Ferrara M, Domenicano I, Marchi A, Zaffarami G, Onofrio A, Benini L, Sorio C, Gentili E, Murri M, Toffanin T, Little J, Grassi L. First episode psychoses in people over-35 years old: uncovering potential actionable targets for early intervention services. Psychiatry Research 2024, 339: 116034. PMID: 38906051, DOI: 10.1016/j.psychres.2024.116034.Peer-Reviewed Original ResearchLong-acting injectable antipsychoticsFirst-episode psychosisEarly intervention servicesPrescribing long-acting injectable antipsychoticsNon-affective first-episode psychosisIntervention servicesCommunity psychiatric servicesInjectable antipsychoticsPsychotic onsetEpisode psychosisAffective psychosisPsychiatric servicesPsychosisExclusion of patientsAccess treatmentClinical characteristicsRetrospective studyOlder patientsPatientsAntipsychoticsAntidepressantsAge groupsWomenGroupIndividualsThe Italian adaptation of the Mini‐SIPS, a tool for early detection of individuals at clinical high risk and first episode of psychosis: A preliminary study of implementation in an Italian FEP program
Ferrara M, Basaldella M, Vacca F, Woods S, Walsh B, Cannon T, Srihari V, Grassi L. The Italian adaptation of the Mini‐SIPS, a tool for early detection of individuals at clinical high risk and first episode of psychosis: A preliminary study of implementation in an Italian FEP program. Early Intervention In Psychiatry 2024 PMID: 38769052, DOI: 10.1111/eip.13548.Peer-Reviewed Original ResearchClinical high riskFirst-episode psychosisDSM-5-Attenuated Psychosis SyndromeItalian adaptationPsychosis syndromeDSM-5FEP programsEarly stages of psychosisItalian versionFirst-episode psychosis servicesFull-blown psychosisStages of psychosisEpisode of psychosisClinical structured interviewEpisode psychosisEstablished psychosisTrained psychologistsPsychiatric historyPsychosisPsychosis servicesHigh riskStructured interviewsClinical settingEarly detection of individualsAssess validityAntipsychotic drugs in first-episode psychosis: a target trial emulation in the FEP-CAUSAL Collaboration
Szmulewicz A, Martínez-Alés G, Logan R, Ferrara M, Kelly C, Fredrikson D, Gago J, Conderino S, Díaz-Caneja C, Galvañ J, Thorpe L, Srihari V, Yatham L, Sarpal D, Shinn A, Arango C, Öngür D, Hernán M, Collaboration O. Antipsychotic drugs in first-episode psychosis: a target trial emulation in the FEP-CAUSAL Collaboration. American Journal Of Epidemiology 2024, 193: 1081-1087. PMID: 38576166, DOI: 10.1093/aje/kwae029.Peer-Reviewed Original ResearchFirst-episode psychosisFirst-generation agentsAntipsychotic therapyAntipsychotic drugsPsychosis onsetPsychotic disordersEpisode psychosisAripiprazolePaliperidoneRisk of hospitalizationPsychosisTarget trialsRisperidoneOlanzapineFirst-line therapyTreatment discontinuationEUFESTObservational cohortAntipsychoticsQuetiapineRandomized trialsPrimary outcomeAbsolute riskRisk differenceClinical questionsDimensions and predictors of clinical and personal recovery in first‐episode psychoses: Results from a cross‐sectional study
Ferrara M, Zaffarami G, Simonelli G, Domenicano I, Vecchioni L, Toffanin T, Folesani F, Zotos S, Scrignoli C, Bertelli R, Carozza P, Grassi L. Dimensions and predictors of clinical and personal recovery in first‐episode psychoses: Results from a cross‐sectional study. Early Intervention In Psychiatry 2024, 18: 455-470. PMID: 38318707, DOI: 10.1111/eip.13513.Peer-Reviewed Original ResearchPersonal recoveryFirst-episode psychosisInvestigate predictors of recoveryRecovery Assessment ScaleDimensions of recoveryNation Outcome ScalesAdjusted logistic regressionCross-sectional studyPositive and Negative Syndrome ScalePredictors of recoveryLong-acting antipsychoticsPromotion interventionsUsual careNegative Syndrome ScalePsychiatric careAssessment ScaleSeverity of symptomatologyPsychiatric hospitalFEP servicesOral antipsychoticsBivariate analysisRecovery dimensionsLogistic regressionCareMale sexRole of Early Psychosis Detection in the Relationship Between Personal Income and Duration of Untreated Psychosis
Venkataraman S, Hazan H, Li F, Ferrara M, Harper A, Ma J, Shah J, Musket C, Levine N, Keshavan M, Srihari V. Role of Early Psychosis Detection in the Relationship Between Personal Income and Duration of Untreated Psychosis. Psychiatric Services 2024, 75: 427-433. PMID: 38204369, DOI: 10.1176/appi.ps.20230239.Peer-Reviewed Original ResearchDuration of untreated psychosisFirst-episode psychosis servicesFirst-episode psychosisEarly psychosis detectionLow personal incomeSocioeconomic statusUntreated psychosisOutcome of first-episode psychosisLength of duration of untreated psychosisEffectiveness of early detectionSpecialty care clinicsProlonged duration of untreated psychosisReduce duration of untreated psychosisEffects of ageLow socioeconomic statusPersonal incomeIndicators of disparitiesEarly detection effortsAssociated with younger ageYears of educationSES indicatorsCare clinicsEarly detectionBlack raceHierarchical regression
2023
First-episode psychosis and autism spectrum disorder: a scoping review and a guide to overcome diagnostic challenges
Ferrara M, Curtarello E, Simonelli G, Yoviene Sykes L, Fusar-Poli L, Folesani F, Belvederi Murri M, Aguglia E, Politi P, Grassi L. First-episode psychosis and autism spectrum disorder: a scoping review and a guide to overcome diagnostic challenges. International Journal Of Mental Health 2023, 53: 4-35. DOI: 10.1080/00207411.2023.2276872.Peer-Reviewed Original ResearchFirst-episode psychosisDifferential diagnosisFEP servicesDiagnostic challengeAutism spectrum disorderAdequate differential diagnosisUndiagnosed autism spectrum disorderComprehensive literature searchPRISMA-ScR guidelinesAdult patientsClinical presentationFunctional recoveryHigh prevalenceSpectrum disorderHigh riskPsychotic symptomsComorbid diagnosesSymptoms of autismSuicidal behaviorLiterature searchDiagnosisSymptomsSensory processingPerceptual abnormalitiesSeparate groups579. Benchmarking Observational Analyses Against Randomized Trial Results: An Application to First Episode Psychosis
Szmulewicz A, Martinez-Ales G, Ferrara M, Fredrikson D, Gago J, Srihari V, Yatham L, Conderino S, Shinn A, Ongur D, Hernán M. 579. Benchmarking Observational Analyses Against Randomized Trial Results: An Application to First Episode Psychosis. Biological Psychiatry 2023, 93: s328-s329. DOI: 10.1016/j.biopsych.2023.02.819.Peer-Reviewed Original Research
2020
Analysis of Early Intervention Services on Adult Judicial Outcomes
Pollard JM, Ferrara M, Lin IH, Kucukgoncu S, Wasser T, Li F, Srihari VH. Analysis of Early Intervention Services on Adult Judicial Outcomes. JAMA Psychiatry 2020, 77: 871-872. PMID: 32320010, PMCID: PMC7177643, DOI: 10.1001/jamapsychiatry.2020.0448.Peer-Reviewed Original Research
2019
Early intervention service for first episode psychosis in Modena, Northern Italy: The first hundred cases
Ferrara M, Tedeschini E, Baccari F, Musella V, Vacca F, Mazzi F, Ferri M, Srihari V, Starace F, Group F. Early intervention service for first episode psychosis in Modena, Northern Italy: The first hundred cases. Early Intervention In Psychiatry 2019, 13: 1011-1017. PMID: 30672134, DOI: 10.1111/eip.12788.Peer-Reviewed Original ResearchConceptsEarly intervention servicesClinical improvementMedian ageIntervention servicesCommunity mental health centerCommunity outpatient servicesPsychiatric hospital unitMeaningful clinical improvementFirst-episode psychosisModel of careNon-affective psychosisNation Outcome ScalesMental health centersHigher median ageEarly detection effortsRefinement of treatmentMain referralsPharmacological consultationYounger patientsUntreated psychosisOutcome ScaleGeneral practitionersEpisode psychosisHealth centersOutpatient services