HTLV-1 induces an inflammatory CD4+CD8+ T cell population in HTLV-1–associated myelopathy
Maher A, Aristodemou A, Giang N, Tanaka Y, Bangham C, Taylor G, Dominguez-Villar M. HTLV-1 induces an inflammatory CD4+CD8+ T cell population in HTLV-1–associated myelopathy. JCI Insight 2024, 9: e173738. PMID: 38193535, PMCID: PMC10906466, DOI: 10.1172/jci.insight.173738.Peer-Reviewed Original ResearchMeSH KeywordsAdultAstrocytesBone Marrow DiseasesCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesHuman T-lymphotropic virus 1HumansParaparesis, Tropical SpasticConceptsHTLV-1-associated myelopathyDP T cellsT cellsHTLV-1Double-positive T cellsAdult T-cell leukemiaT cell populationsT-cell tropismHTLV-1 infectionHuman T-cell leukemia virus type 1Virus type 1T-cell leukemiaCXCR3 expressionPreferential CD4Asymptomatic infectionCNS pathologyIL-6Asymptomatic carriersInflammatory diseasesCytotoxic phenotypeCell leukemiaCell tropismType 1CD4Cell populations