Sphingosine‐1‐Phosphate Signalling Inhibition Suppresses Th1‐Like Treg Generation by Reversing Mitochondrial Uncoupling
Coulombeau R, Selck C, Giang N, Al‐Mohammad A, Ng N, Maher A, Argüello R, Scalfari A, Varley J, Nicholas R, Dominguez‐Villar M. Sphingosine‐1‐Phosphate Signalling Inhibition Suppresses Th1‐Like Treg Generation by Reversing Mitochondrial Uncoupling. Immunology 2024 PMID: 39444366, DOI: 10.1111/imm.13870.Peer-Reviewed Original ResearchTh1-like TregsSphingosine-1-phosphateSuppressive functionMitochondrial uncouplingSignaling inhibitionIncreased suppressive functionMultiple sclerosisTreg plasticityTreg reprogrammingTreg frequencyTreg generationTregsAutoimmune conditionsExpression of genesInflammatory environmentMS patientsS1P inhibitionFTY720Defective functionS1PMTORC1 signalingInhibitionReprogramming