Margaret Hostetter
Professor AdjunctCards
About
Titles
Professor Adjunct
Physician-in-Chief, Yale-New Haven Children's Hospital; Chair, Department of Pediatrics; Section Chief, Pediatric Immunology
Biography
Director of the Yale Child Health Research Center since 1998 and Chair of Yale's Department of Pediatrics since 2002, Hostetter is a specialist in pediatric infectious diseases and in the evaluation of internationally adopted children. Her studies of Streptococcus pneumoniae, a leading global respiratory pathogen, and Candida albicans, a yeast that infects immunocompromised patients, have been supported by the NIH and private foundations for more than 25 years. She and members of her laboratory hold five patents for discoveries in these areas.
She also serves as program director of the Pediatric Scientist Development Program, a multi-million dollar training program for pediatric physician-scientists funded by the National Institute of Child Health and Human Development. Prior to coming to Yale, Hostetter held the American Legion Heart Research Chair in Pediatrics at the University of Minnesota and headed the Division of Pediatric Infectious Diseases.Hostetter's honors include the American Academy of Pediatrics Award for Excellence in Research, the Samuel Rosenthal Award for contributions to academic pediatrics, and the E. Mead Johnson Award for Pediatric Research from the Society for Pediatric Research (SPR). She is a member of the Institute of Medicine of the National Academy of Sciences.
She also serves as program director of the Pediatric Scientist Development Program, a multi-million dollar training program for pediatric physician-scientists funded by the National Institute of Child Health and Human Development. Prior to coming to Yale, Hostetter held the American Legion Heart Research Chair in Pediatrics at the University of Minnesota and headed the Division of Pediatric Infectious Diseases.Hostetter's honors include the American Academy of Pediatrics Award for Excellence in Research, the Samuel Rosenthal Award for contributions to academic pediatrics, and the E. Mead Johnson Award for Pediatric Research from the Society for Pediatric Research (SPR). She is a member of the Institute of Medicine of the National Academy of Sciences.
Appointments
Departments & Organizations
- Yale Child Health Research Center
Education & Training
- Fellow
- Boston Children's, Harvard (1980)
- Intern & Resident
- Boston Children's Hospital, Harvard (1978)
Board Certifications
Pediatrics
- Certification Organization
- AB of Pediatrics
- Original Certification Date
- 1981
Research
Overview
Among the fungi, the yeast Candida albicans is the leading cause of death in susceptible hosts including premature newborns, patients with cancer, and other immunocompromised patients. Expanding upon our prior characterization of functions of the Int1 protein in adhesion and filamentous growth (Science 279:1355-8, 1998), we have defined new roles for this protein in superantigen-mediated injury, heparin binding, and biofilm formation. Other projects in the laboratory focus on the involvement of the mitochondrial proteome in C. albicans morphogenesis and on the mechanisms whereby this yeast invades the human gastrointestinal tract. In vitro models of gastrointestinal invasion are particularly interesting because of the novel linkage between C. albicans proteases, epithelial E-cadherin, and signaling via the gamma-secretase pathway.
- How heparin enhances the ability of Candida albicans to evade innate immunity
- Statins as inhibitors of Candida albicans biofilm
- High throughput screening to identify other inhibitors of C. albicans biofilm
Academic Achievements & Community Involvement
News & Links
Media
News
- May 22, 2023
Retrospective
- October 31, 2004
Electronic Records to Improve Care for Children with Asthma
- April 21, 2004
Primary Immunodeficiency Diagnostic Center Opens at Yale During PI Awareness Week
- November 13, 2003
First Prematurity Awareness Day Marked by Star Chefs Auction Co-Chaired by Yale School of Medicine Leader