2024
Cost-Effectiveness of Implementation Facilitation to Promote Emergency Department-Initiated Buprenorphine for Opioid Use Disorder
Lu T, Ryan D, Cadet T, Chawarski M, Coupet E, Edelman E, Hawk K, Huntley K, Jalali A, O'Connor P, Owens P, Martel S, Fiellin D, D'Onofrio G, Murphy S. Cost-Effectiveness of Implementation Facilitation to Promote Emergency Department-Initiated Buprenorphine for Opioid Use Disorder. Annals Of Emergency Medicine 2024 PMID: 39570250, DOI: 10.1016/j.annemergmed.2024.10.001.Peer-Reviewed Original ResearchHealth care sector perspectiveImplementation facilitatorsOpioid use disorder careIncremental cost-effectiveness ratioCost-effectiveness ratioHealth care sector costsEducational strategiesImplementation facilitation strategyCost-effectiveness acceptability curvesLikelihood of cost-effectivenessCost-effectiveOpioid use disorderQuality-adjusted life yearsUse disorderPatient engagementAcademic EDED visitsAcceptability curvesStandard educationEmergency departmentLife yearsFacilitation strategiesMeasures of effectivenessHealthBuprenorphine403EMF Barriers and Facilitators to Addiction Treatment Access From the Emergency Department Among Black Individuals With Opioid Use Disorder
Coupet E, Chawarski M, Hercules K, Williams J, Murphy A, Owens P, D'Onofrio G. 403EMF Barriers and Facilitators to Addiction Treatment Access From the Emergency Department Among Black Individuals With Opioid Use Disorder. Annals Of Emergency Medicine 2024, 84: s182-s183. DOI: 10.1016/j.annemergmed.2024.08.403.Peer-Reviewed Original ResearchW81 Implementation Facilitation Improves Clinician Readiness to Provide Emergency Department-Initiated Buprenorphine in Four Urban Academic Centers
Hawk K, D'Onofrio G, Chawarski M, Coupet E, Cowan E, Curry L, Freiermurth C, Lyons M, Murphy A, O'Connor P, Richardson L, Rothman R, Whiteside L, Williams J, Fiellin D, Edelman E. W81 Implementation Facilitation Improves Clinician Readiness to Provide Emergency Department-Initiated Buprenorphine in Four Urban Academic Centers. Drug And Alcohol Dependence 2024, 260: 110699. DOI: 10.1016/j.drugalcdep.2023.110699.Peer-Reviewed Original ResearchM162 Phytochemical Composition of Fresh Kratom Leaves Collected in the Northern Region of Malaysia
Karunakaran T, Kasinather V, Chawarski M. M162 Phytochemical Composition of Fresh Kratom Leaves Collected in the Northern Region of Malaysia. Drug And Alcohol Dependence 2024, 260: 110442. DOI: 10.1016/j.drugalcdep.2023.110442.Peer-Reviewed Original ResearchT45 Changing Characteristics of HIV/AIDS Epidemic in Malaysia
Kasinather V, Ramadah R, Singh D, Chooi W, Zaharim N, Chawarski M. T45 Changing Characteristics of HIV/AIDS Epidemic in Malaysia. Drug And Alcohol Dependence 2024, 260: 110494. DOI: 10.1016/j.drugalcdep.2023.110494.Peer-Reviewed Original ResearchPhytochemical analysis of water and ethanol liquid extracts prepared using freshly harvested leaves of Mitragyna speciosa (Korth.)
Karunakaran T, Vicknasingam B, Chawarski M. Phytochemical analysis of water and ethanol liquid extracts prepared using freshly harvested leaves of Mitragyna speciosa (Korth.). Natural Product Research 2024, ahead-of-print: 1-8. PMID: 38842220, DOI: 10.1080/14786419.2024.2362428.Peer-Reviewed Original ResearchFreshly harvested leavesPhytochemical compositionO-coumaric acidDried leaf materialLiquid extractionSpectrum of phytochemicalsKratom leavesBioactive phenolicsChlorogenic acidPhytochemical analysisWater extractLeaf materialLeavesLCMS/MS analysisAnalysis of waterMass spectraFreshlyExtractionLeaves of Mitragyna speciosaSpectrometric methodOxidized derivativesRutinQuercitrinAcidPhytochemicalsResearch and publication gaps on kratom and kratom products: a scoping review of current literature
Vicknasingam B, Karunakaran T, Chawarski M. Research and publication gaps on kratom and kratom products: a scoping review of current literature. Current Opinion In Psychiatry 2024, 37: 282-291. PMID: 38818826, DOI: 10.1097/yco.0000000000000950.Peer-Reviewed Original ResearchConceptsHealth system databasePublic health impactPublic health consequencesPrevalence ratesNational surveyHealth impactsPublic healthPublication gapSystem databaseCase series reportControlled clinical studiesClinical case reportEpidemiological factorsEpidemiological surveillanceCase reportScopus databasesSeries reportClinical studiesKratom productsSurveyHuman laboratoryResearch articlesKratomHealthAnalytical study
2023
Evaluation of toxicity profile of kratom (Mitragyna speciosa Korth) decoction in rats
Hassan Z, Singh D, Suhaimi F, Chear N, Harun N, See C, Kaur G, Mat N, Bakar S, Yusof N, Kasinather V, Chawarski M, Murugaiyah V, Ramanathan S. Evaluation of toxicity profile of kratom (Mitragyna speciosa Korth) decoction in rats. Regulatory Toxicology And Pharmacology 2023, 143: 105466. PMID: 37536550, DOI: 10.1016/j.yrtph.2023.105466.Peer-Reviewed Original ResearchConceptsDays of treatmentToxicity profileFemale Sprague-Dawley ratsOpioid replacement therapyLow platelet countEnd of treatmentSprague-Dawley ratsEvidence of toxicityOccurrence of mortalityPlatelet countDawley ratsHematology profileBody weightMitragyna speciosa KorthBrain tissueHistopathology analysisHistological investigationHerbal drug preparationsDecoctionUric acidDrug preparationTherapeutic propertiesKidneyMortalityRatsPerspectives on and experiences of emergency department–initiated buprenorphine among clinical pharmacists: A multi-site qualitative study
Justen M, Edelman E, Chawarski M, Coupet E, Cowan E, Lyons M, Owens P, Martel S, Richardson L, Rothman R, Whiteside L, O'Connor P, Zahn E, D'Onofrio G, Fiellin D, Hawk K. Perspectives on and experiences of emergency department–initiated buprenorphine among clinical pharmacists: A multi-site qualitative study. Journal Of Substance Use And Addiction Treatment 2023, 155: 209058. PMID: 37149149, DOI: 10.1016/j.josat.2023.209058.Peer-Reviewed Original ResearchConceptsOpioid use disorderClinical pharmacistsED careEmergency department-initiated buprenorphineEffective OUD treatmentEffectiveness-implementation studyHealth Services frameworkFocus groups/interviewsMulti-site qualitative studyFuture implementation effortsOUD treatmentUrban EDGroups/interviewsEmergency departmentPromoting ActionUnique pharmacologyED staffBuprenorphinePharmacist participantsUse disordersED contextPharmacistsPractice changePharmacy resourcesSuccessful program implementationPerspectives of Clinicians and Staff at Community-Based Opioid Use Disorder Treatment Settings on Linkages With Emergency Department–Initiated Buprenorphine Programs
Sue K, Chawarski M, Curry L, McNeil R, Coupet E, Schwartz R, Wilder C, Tsui J, Hawk K, D’Onofrio G, O’Connor P, Fiellin D, Edelman E. Perspectives of Clinicians and Staff at Community-Based Opioid Use Disorder Treatment Settings on Linkages With Emergency Department–Initiated Buprenorphine Programs. JAMA Network Open 2023, 6: e2312718. PMID: 37163263, PMCID: PMC10173026, DOI: 10.1001/jamanetworkopen.2023.12718.Peer-Reviewed Original ResearchConceptsCommunity-based cliniciansOpioid use disorderEmergency departmentOUD treatmentMedication treatmentSubstance use disorders trainingUrban academic emergency departmentEffectiveness-implementation studyAcademic emergency departmentDisorder treatment settingsPerspectives of cliniciansCommunity-based treatmentCommunity-based treatment programsStaff perspectivesImplementation science frameworkBuprenorphine programTreatment cliniciansPeer navigatorsReferral sitesPromoting ActionMAIN OUTCOMEED staffBuprenorphineFocus groupsUse disordersImplementation Facilitation to Promote Emergency Department–Initiated Buprenorphine for Opioid Use Disorder
D’Onofrio G, Edelman E, Hawk K, Chawarski M, Pantalon M, Owens P, Martel S, Rothman R, Saheed M, Schwartz R, Cowan E, Richardson L, Salsitz E, Lyons M, Freiermuth C, Wilder C, Whiteside L, Tsui J, Klein J, Coupet E, O’Connor P, Matthews A, Murphy S, Huntley K, Fiellin D. Implementation Facilitation to Promote Emergency Department–Initiated Buprenorphine for Opioid Use Disorder. JAMA Network Open 2023, 6: e235439. PMID: 37017967, PMCID: PMC10077107, DOI: 10.1001/jamanetworkopen.2023.5439.Peer-Reviewed Original ResearchConceptsOpioid use disorderRate of patientsOUD treatmentImplementation facilitationED visitsObservational cohortED cliniciansX-waiverUse disordersEmergency Department-Initiated BuprenorphineUntreated opioid use disorderEvaluation periodHybrid type 3Provision of buprenorphineBaseline periodGrand roundsRates of EDPrimary outcomeWhite patientsAcademic EDBlack patientsED patientsEmergency departmentCommunity cliniciansMAIN OUTCOMEKratom withdrawal: Discussions and conclusions of a scientific expert forum
Henningfield J, Chawarski M, Garcia-Romeu A, Grundmann O, Harun N, Hassan Z, McCurdy C, McMahon L, Sharma A, Shoaib M, Singh D, Smith K, Swogger M, Vicknasingam B, Walsh Z, Wang D, Huestis M. Kratom withdrawal: Discussions and conclusions of a scientific expert forum. Drug And Alcohol Dependence Reports 2023, 7: 100142. PMID: 37397437, PMCID: PMC10311168, DOI: 10.1016/j.dadr.2023.100142.Peer-Reviewed Original Research
2022
Analgesic effects of main indole alkaloid of kratom, mitragynine in acute pain animal model
Mat N, Bakar S, Murugaiyah V, Chawarski M, Hassan Z. Analgesic effects of main indole alkaloid of kratom, mitragynine in acute pain animal model. Behavioural Brain Research 2022, 439: 114251. PMID: 36503042, DOI: 10.1016/j.bbr.2022.114251.Peer-Reviewed Original ResearchConceptsAnti-inflammatory propertiesAnalgesic effectTRPV1 expressionAcute pain animal modelsEffective doseFemale Sprague-Dawley ratsPain animal modelsPain-like behaviorsNon-opioid receptorsOpioid receptor activationNumber of writhesSprague-Dawley ratsInflammatory painPain pathwaysTRPV1 receptorsDawley ratsWrithing behaviorED95 valuesRat brainAnimal modelsReceptor activationReceptor pathwayRatsBehavior scoresMain indole alkaloidsMissed Opportunities for HIV and Hepatitis C Screening Among Emergency Department Patients With Untreated Opioid Use Disorder
Lyons MS, Chawarski MC, Rothman R, Whiteside L, Cowan E, Richardson LD, Hawk K, Tsui JI, Schwartz RP, O’Connor P, D’Onofrio G, Fiellin DA, Edelman EJ. Missed Opportunities for HIV and Hepatitis C Screening Among Emergency Department Patients With Untreated Opioid Use Disorder. Journal Of Addiction Medicine 2022, 17: 210-214. PMID: 36170184, PMCID: PMC10023471, DOI: 10.1097/adm.0000000000001074.Peer-Reviewed Original ResearchConceptsUntreated opioid use disorderOpioid use disorderRecent injection drug useEmergency department HIVInjection drug useHCV screeningED patientsUse disordersEnrollment periodDrug useHepatitis C screeningStructured screening programmeUnknown HCV statusUnknown HIV statusHigh-risk cohortMedical care providersHCV statusC screeningHepatitis CED visitsAcademic EDHIV statusEmergency departmentCohort 2Cohort 1Perspectives About Emergency Department Care Encounters Among Adults With Opioid Use Disorder
Hawk K, McCormack R, Edelman EJ, Coupet E, Toledo N, Gauthier P, Rotrosen J, Chawarski M, Martel S, Owens P, Pantalon MV, O’Connor P, Whiteside LK, Cowan E, Richardson LD, Lyons MS, Rothman R, Marsch L, Fiellin DA, D’Onofrio G. Perspectives About Emergency Department Care Encounters Among Adults With Opioid Use Disorder. JAMA Network Open 2022, 5: e2144955. PMID: 35076700, PMCID: PMC8790663, DOI: 10.1001/jamanetworkopen.2021.44955.Peer-Reviewed Original ResearchConceptsUntreated opioid use disorderOpioid use disorderEmergency departmentED visitsOUD treatmentUse disordersPublic safety-net hospitalRural critical access hospitalsEmergency department careSafety-net hospitalUrban academic centerLife-saving treatmentCritical access hospitalsImplementation science frameworkPatient factorsTreatment initiationED careUS patientsStaff trainingDemand treatmentPatient readinessNet hospitalPatient's perspectivePromoting ActionImproved care
2021
Legal challenges in providing treatment for people who use drugs (PWUDs) in Malaysia
Vicknasingam B, Salleh N, Ramadah R, Singh D, Kamarulzaman A, Chawarski MC. Legal challenges in providing treatment for people who use drugs (PWUDs) in Malaysia. International Journal Of Drug Policy 2021, 97: 103311. PMID: 34111680, PMCID: PMC8585679, DOI: 10.1016/j.drugpo.2021.103311.Peer-Reviewed Original ResearchApplication of Chinese version of behavioral activation for depression scale in patients in methadone maintenance treatment
Ma H, Chen Y, Yan H, Liu P, Wang X, Daughters S, Chawarski M, Zhou W. Application of Chinese version of behavioral activation for depression scale in patients in methadone maintenance treatment. Chinese Journal Of Behavioral Medicine And Brain Science 2021, 30: 459-464. DOI: 10.3760/cma.j.cn371468-20200723-01586.Peer-Reviewed Original ResearchMethadone maintenance treatmentMaintenance treatmentDepression ScaleBehavioral activationTotal scoreItem-total score correlation coefficientsChinese versionWork/schoolExploratory factor analysisGood internal consistency reliabilityMMT programOpioid addictsActivation subscaleInternal consistency reliabilityPatientsCronbach's αAvoidance/Split-half reliability coefficientConsistency reliabilityConfirmatory factor analysisSubscalesActivationSPSS 21.0Correlation coefficientBehavior activationCOVID-19 Impact on Healthcare and Supportive Services for People Who Use Drugs (PWUDs) in Malaysia
Vicknasingam B, Salleh N, Chooi WT, Singh D, Zaharim N, Kamarulzaman A, Chawarski MC. COVID-19 Impact on Healthcare and Supportive Services for People Who Use Drugs (PWUDs) in Malaysia. Frontiers In Psychiatry 2021, 12: 630730. PMID: 33854449, PMCID: PMC8039131, DOI: 10.3389/fpsyt.2021.630730.Peer-Reviewed Original ResearchMethadone maintenance treatment programTake-home dosesMaintenance treatment programCOVID-19 infectionDelivery of medicationsSupportive servicesHIV clinicMMT patientsTreatment disruptionPerson visitsTreatment protocolPatient's homeStudy participantsTreatment programCOVID-19 epidemicPatient flowTelemedicine resourcesCOVID-19 responseMedical personnelMedicationsPatientsLower ratesSemi-structured formatMovement Control OrderRecipientsSubstance Use Problems/Disorders in Individuals with ASD
Øien R, Nordahl-Hansen A, Chawarski M. Substance Use Problems/Disorders in Individuals with ASD. 2021, 4671-4673. DOI: 10.1007/978-3-319-91280-6_102122.Peer-Reviewed Original ResearchA qualitative study of emergency department patients who survived an opioid overdose: Perspectives on treatment and unmet needs
Hawk K, Grau LE, Fiellin DA, Chawarski M, O’Connor P, Cirillo N, Breen C, D’Onofrio G. A qualitative study of emergency department patients who survived an opioid overdose: Perspectives on treatment and unmet needs. Academic Emergency Medicine 2021, 28: 542-552. PMID: 33346926, PMCID: PMC8281441, DOI: 10.1111/acem.14197.Peer-Reviewed Original ResearchConceptsOpioid use disorderEmergency departmentSubstance use treatmentOpioid overdosePatient's perspectiveUnmet needUse treatmentAcute opioid overdoseAdult ED patientsEmergency department patientsPatient support servicesProvider communication skillsEmergency medicine cliniciansAcademic emergency departmentSocial ecologic modelEvidence-based treatmentsChoice of patientsBrief quantitative surveyPatient-oriented approachOpioid useDepartment patientsOUD treatmentUnmet basic needsED careED patients