2024
Research and publication gaps on kratom and kratom products: a scoping review of current literature
Vicknasingam B, Karunakaran T, Chawarski M. Research and publication gaps on kratom and kratom products: a scoping review of current literature. Current Opinion In Psychiatry 2024, 37: 282-291. PMID: 38818826, DOI: 10.1097/yco.0000000000000950.Peer-Reviewed Original ResearchConceptsHealth system databasePublic health impactPublic health consequencesPrevalence ratesNational surveyHealth impactsPublic healthPublication gapSystem databaseCase series reportControlled clinical studiesClinical case reportEpidemiological factorsEpidemiological surveillanceCase reportScopus databasesSeries reportClinical studiesKratom productsSurveyHuman laboratoryResearch articlesKratomHealthAnalytical study
2023
Evaluation of toxicity profile of kratom (Mitragyna speciosa Korth) decoction in rats
Hassan Z, Singh D, Suhaimi F, Chear N, Harun N, See C, Kaur G, Mat N, Bakar S, Yusof N, Kasinather V, Chawarski M, Murugaiyah V, Ramanathan S. Evaluation of toxicity profile of kratom (Mitragyna speciosa Korth) decoction in rats. Regulatory Toxicology And Pharmacology 2023, 143: 105466. PMID: 37536550, DOI: 10.1016/j.yrtph.2023.105466.Peer-Reviewed Original ResearchConceptsDays of treatmentToxicity profileFemale Sprague-Dawley ratsOpioid replacement therapyLow platelet countEnd of treatmentSprague-Dawley ratsEvidence of toxicityOccurrence of mortalityPlatelet countDawley ratsHematology profileBody weightMitragyna speciosa KorthBrain tissueHistopathology analysisHistological investigationHerbal drug preparationsDecoctionUric acidDrug preparationTherapeutic propertiesKidneyMortalityRats
2022
Analgesic effects of main indole alkaloid of kratom, mitragynine in acute pain animal model
Mat N, Bakar S, Murugaiyah V, Chawarski M, Hassan Z. Analgesic effects of main indole alkaloid of kratom, mitragynine in acute pain animal model. Behavioural Brain Research 2022, 439: 114251. PMID: 36503042, DOI: 10.1016/j.bbr.2022.114251.Peer-Reviewed Original ResearchConceptsAnti-inflammatory propertiesAnalgesic effectTRPV1 expressionAcute pain animal modelsEffective doseFemale Sprague-Dawley ratsPain animal modelsPain-like behaviorsNon-opioid receptorsOpioid receptor activationNumber of writhesSprague-Dawley ratsInflammatory painPain pathwaysTRPV1 receptorsDawley ratsWrithing behaviorED95 valuesRat brainAnimal modelsReceptor activationReceptor pathwayRatsBehavior scoresMain indole alkaloids
2020
Kratom and Pain Tolerance: A Randomized, Placebo-Controlled, Double-Blind Study.
Vicknasingam B, Chooi WT, Rahim AA, Ramachandram D, Singh D, Ramanathan S, Yusof NSM, Zainal H, Murugaiyah V, Gueorguieva R, Mansor SM, Chawarski MC. Kratom and Pain Tolerance: A Randomized, Placebo-Controlled, Double-Blind Study. The Yale Journal Of Biology And Medicine 2020, 93: 229-238. PMID: 32607084, PMCID: PMC7309661.Peer-Reviewed Original ResearchConceptsDouble-blind studyPain toleranceCold pressor taskConsumption of placeboSigns of withdrawalKratom consumptionTraditional medicine useKratom ingestionPain reliefPain onsetInpatient staySafety profileMedicine useWithdrawal symptomsPlacebo drinkHand withdrawalHealth statusVital signsKratom productsSelf-reported dataRandomized sequencePlaceboKratomSignificant increaseDecoction