2012
Cost-Effectiveness of Buprenorphine and Naltrexone Treatments for Heroin Dependence in Malaysia
Ruger JP, Chawarski M, Mazlan M, Ng N, Schottenfeld R. Cost-Effectiveness of Buprenorphine and Naltrexone Treatments for Heroin Dependence in Malaysia. PLOS ONE 2012, 7: e50673. PMID: 23226534, PMCID: PMC3514172, DOI: 10.1371/journal.pone.0050673.Peer-Reviewed Original ResearchConceptsHeroin dependenceCost-effectiveness ratioSecondary outcomesOutcome measuresDrug usePlacebo-controlled clinical trialFirst heroin useIncremental cost-effectiveness ratioSocietal costsInjection drug useSecondary outcome measuresPrimary outcome measureIllicit opiate useIncremental treatment costNaltrexone treatmentPrimary outcomeMedication costsPlacebo interventionClinical trialsHeroin abstinenceOpiate useHeroin useBuprenorphineTreatment retentionNaltrexoneLifetime ATS use and increased HIV risk among not-in-treatment opiate injectors in Malaysia
Chawarski MC, Vicknasingam B, Mazlan M, Schottenfeld RS. Lifetime ATS use and increased HIV risk among not-in-treatment opiate injectors in Malaysia. Drug And Alcohol Dependence 2012, 124: 177-180. PMID: 22266088, PMCID: PMC4641448, DOI: 10.1016/j.drugalcdep.2011.12.024.Peer-Reviewed Original ResearchConceptsOpiate injectorsHIV infectionHIV statusATS useLifetime historyAmphetamine-type stimulantsHIV-negative participantsHIV transmission riskHIV-positive participantsDrug use historyPublic health prevention measuresHigh-risk behaviorsHealth prevention measuresTreatment IDUsVs. 75HIV transmissionRisk factorsPositive participantsHIV riskHigh riskRisk behaviorsDrug abuse problemsTransmission riskDrug abuseIDUs
2010
Behavioral drug and HIV risk reduction counseling (BDRC) in MMT programs in Wuhan, China: A pilot randomized clinical trial
Chawarski MC, Zhou W, Schottenfeld RS. Behavioral drug and HIV risk reduction counseling (BDRC) in MMT programs in Wuhan, China: A pilot randomized clinical trial. Drug And Alcohol Dependence 2010, 115: 237-239. PMID: 21159452, PMCID: PMC3076517, DOI: 10.1016/j.drugalcdep.2010.09.024.Peer-Reviewed Original ResearchConceptsHIV risk reduction counselingMethadone maintenance treatmentRisk reduction counselingIllicit opiate useHIV risk behaviorsBehavioral drugReduction counselingClinical trialsOpiate useMMT servicesRisk behaviorsPrimary outcome measurePilot clinical trialTime of enrollmentSignificant baseline differencesHeroin-dependent individualsNegative test resultsMMT clinicsDaily medicationMaintenance treatmentMMT programBaseline differencesOutcome measuresMMT groupTreatment retentionInjection of buprenorphine and buprenorphine/naloxone tablets in Malaysia
Vicknasingam B, Mazlan M, Schottenfeld RS, Chawarski MC. Injection of buprenorphine and buprenorphine/naloxone tablets in Malaysia. Drug And Alcohol Dependence 2010, 111: 44-49. PMID: 20478668, DOI: 10.1016/j.drugalcdep.2010.03.014.Peer-Reviewed Original ResearchConceptsBuprenorphine/naloxone tabletsInjection of buprenorphineInjection drug usersMisuse of buprenorphineFirst wave participantsBuprenorphine maintenanceOpioid dependenceBenzodiazepine abuseBuprenorphineDrug usersSecond-wave surveyIDUsFocus group participantsCombination tabletGroup participantsPreliminary dataSurvey participantsParticipantsFocus groupsWithdrawalAbuseDiversionSecond waveKuala Lumpur
2008
Maintenance treatment with buprenorphine and naltrexone for heroin dependence in Malaysia: a randomised, double-blind, placebo-controlled trial
Schottenfeld RS, Chawarski MC, Mazlan M. Maintenance treatment with buprenorphine and naltrexone for heroin dependence in Malaysia: a randomised, double-blind, placebo-controlled trial. The Lancet 2008, 371: 2192-2200. PMID: 18586174, PMCID: PMC4041792, DOI: 10.1016/s0140-6736(08)60954-x.Peer-Reviewed Original ResearchConceptsFirst heroin useHIV risk behaviorsHeroin dependenceHeroin useHeroin relapseMaintenance treatmentHeroin abstinenceDrug counsellingComputer-generated randomisation sequenceRisk behaviorsEffective public health approachConsecutive daysInterim safety analysisOutpatient research clinicPlacebo-controlled trialEfficacy of naltrexoneHeroin-dependent patientsMonths of enrollmentPrevention of relapseWorldwide health priorityPublic health approachRandomisation sequencePrimary outcomeHIV transmissionHIV risk
2007
Buprenorphine/naloxone treatment in primary care is associated with decreased human immunodeficiency virus risk behaviors
Sullivan LE, Moore BA, Chawarski MC, Pantalon MV, Barry D, O'Connor PG, Schottenfeld RS, Fiellin DA. Buprenorphine/naloxone treatment in primary care is associated with decreased human immunodeficiency virus risk behaviors. Journal Of Substance Use And Addiction Treatment 2007, 35: 87-92. PMID: 17933486, PMCID: PMC2587397, DOI: 10.1016/j.jsat.2007.08.004.Peer-Reviewed Original ResearchConceptsBuprenorphine/naloxone treatmentNaloxone treatmentHIV risk behaviorsHIV riskRisk behaviorsHuman immunodeficiency virus (HIV) risk behaviorsDrug-related HIV riskHuman immunodeficiency virus (HIV) riskSex-related HIV risk behaviorsBuprenorphine/naloxoneIntravenous drug useOpioid-dependent personsPrimary care clinicsInconsistent condom useBuprenorphine/Care clinicsMethadone treatmentPrimary careDrug useSteady partnerCondom useBaselineWeeksTreatmentPatients
2006
ASIA PACIFIC COLUMN: New challenges and opportunities in managing substance abuse in Malaysia
MAZLAN M, SCHOTTENFELD RS, CHAWARSKI MC. ASIA PACIFIC COLUMN: New challenges and opportunities in managing substance abuse in Malaysia. Drug And Alcohol Review 2006, 25: 473-478. PMID: 16939945, DOI: 10.1080/09595230600883354.Peer-Reviewed Original ResearchConceptsStimulant abuseDrug useRelated disordersAgonist maintenance treatmentInjection drug useHealth careHigh HIV prevalenceHeroin-dependent individualsOpiate-dependent patientsSevere drug problemsInfectious disease ratesAgonist medicationsHIV casesMaintenance treatmentHIV prevalenceCountry's health careHeroin abusersMedical treatmentHeroin usersTreatment approachesDrug abusersDrug usersAdult populationDisease ratesSubstance abuseHeroin dependence and HIV infection in Malaysia
Chawarski MC, Mazlan M, Schottenfeld RS. Heroin dependence and HIV infection in Malaysia. Drug And Alcohol Dependence 2006, 82: s39-s42. PMID: 16769444, DOI: 10.1016/s0376-8716(06)80007-4.Peer-Reviewed Original ResearchConceptsInjection drug useCurrent injection drug useLifetime injection drug useHIV infectionNeedle sharingHepatitis CHeroin dependenceHigh prevalenceDrug useMajor risk factorChest X-rayHeroin-dependent individualsHIV risk behaviorsHeroin-dependent subjectsConsistent condom useAddiction Severity IndexDrug abuse treatmentRadiological evidenceHepatitis BMean ageRisk factorsClinical trialsMalay ethnicityBaseline assessmentHIV
1998
Assessment of HIV Risk
Chawarski M, Pakes J, Schottenfeld R. Assessment of HIV Risk. Journal Of Addictive Diseases 1998, 17: 49-59. PMID: 9848031, DOI: 10.1300/j069v17n04_05.Peer-Reviewed Original Research