2023
Evaluation of toxicity profile of kratom (Mitragyna speciosa Korth) decoction in rats
Hassan Z, Singh D, Suhaimi F, Chear N, Harun N, See C, Kaur G, Mat N, Bakar S, Yusof N, Kasinather V, Chawarski M, Murugaiyah V, Ramanathan S. Evaluation of toxicity profile of kratom (Mitragyna speciosa Korth) decoction in rats. Regulatory Toxicology And Pharmacology 2023, 143: 105466. PMID: 37536550, DOI: 10.1016/j.yrtph.2023.105466.Peer-Reviewed Original ResearchConceptsDays of treatmentToxicity profileFemale Sprague-Dawley ratsOpioid replacement therapyLow platelet countEnd of treatmentSprague-Dawley ratsEvidence of toxicityOccurrence of mortalityPlatelet countDawley ratsHematology profileBody weightMitragyna speciosa KorthBrain tissueHistopathology analysisHistological investigationHerbal drug preparationsDecoctionUric acidDrug preparationTherapeutic propertiesKidneyMortalityRats
2020
Kratom and Pain Tolerance: A Randomized, Placebo-Controlled, Double-Blind Study.
Vicknasingam B, Chooi WT, Rahim AA, Ramachandram D, Singh D, Ramanathan S, Yusof NSM, Zainal H, Murugaiyah V, Gueorguieva R, Mansor SM, Chawarski MC. Kratom and Pain Tolerance: A Randomized, Placebo-Controlled, Double-Blind Study. The Yale Journal Of Biology And Medicine 2020, 93: 229-238. PMID: 32607084, PMCID: PMC7309661.Peer-Reviewed Original ResearchConceptsDouble-blind studyPain toleranceCold pressor taskConsumption of placeboSigns of withdrawalKratom consumptionTraditional medicine useKratom ingestionPain reliefPain onsetInpatient staySafety profileMedicine useWithdrawal symptomsPlacebo drinkHand withdrawalHealth statusVital signsKratom productsSelf-reported dataRandomized sequencePlaceboKratomSignificant increaseDecoction