1993
Activated release of membrane-anchored TGF-alpha in the absence of cytosol
Bosenberg M, Pandiella A, Massagué J. Activated release of membrane-anchored TGF-alpha in the absence of cytosol. Journal Of Cell Biology 1993, 122: 95-101. PMID: 8314849, PMCID: PMC2119606, DOI: 10.1083/jcb.122.1.95.Peer-Reviewed Original ResearchMeSH KeywordsAluminumAluminum CompoundsAnimalsCell MembraneCell Membrane PermeabilityCHO CellsCricetinaeFluoridesFluorineGTP-Binding ProteinsGuanosine 5'-O-(3-Thiotriphosphate)Guanosine DiphosphateKineticsProtein Kinase CProtein PrecursorsProtein Processing, Post-TranslationalRatsRecombinant ProteinsTetradecanoylphorbol AcetateThionucleotidesTransfectionTransforming Growth Factor alphaConceptsMembrane-anchored growth factorsHeterotrimeric G proteinsCell surfaceIndependent protein kinase CCellular proteolytic systemsStreptolysin OProtein kinase CAbsence of cytosolVesicular trafficCytoplasmic tailATP hydrolysisProteolytic componentKinase CG proteinsProteolytic systemIntact cellsPermeabilized cellsGTP gamma SBiochemical componentsCytosolAlpha cleavageTGF-alphaRegulated systemGamma SGrowth factor
1992
The cytoplasmic carboxy-terminal amino acid specifies cleavage of membrane TGFα into soluble growth factor
Bosenberg M, Pandiella A, Massagué J. The cytoplasmic carboxy-terminal amino acid specifies cleavage of membrane TGFα into soluble growth factor. Cell 1992, 71: 1157-1165. PMID: 1473151, DOI: 10.1016/s0092-8674(05)80064-9.Peer-Reviewed Original Research