2019
Functional Ontogeny of Hypothalamic Agrp Neurons in Neonatal Mouse Behaviors
Zimmer MR, Fonseca AHO, Iyilikci O, Pra RD, Dietrich MO. Functional Ontogeny of Hypothalamic Agrp Neurons in Neonatal Mouse Behaviors. Cell 2019, 178: 44-59.e7. PMID: 31104844, PMCID: PMC6688755, DOI: 10.1016/j.cell.2019.04.026.Peer-Reviewed Original ResearchConceptsHypothalamic AgRP neuronsAgRP neuronsAdult micePostnatal day 10 miceVivo fiber photometryFunctional ontogenyIsolation-induced ultrasonic vocalizationsNon-nutritive sucklingUltrasonic vocalizationsMilk ingestionFiber photometryMilk deprivationFood ingestionNeuronsMiceMouse behaviorIngestionNeonatesGABALittermatesOveractivationRegulation of substrate utilization and adiposity by Agrp neurons
Cavalcanti-de-Albuquerque JP, Bober J, Zimmer MR, Dietrich MO. Regulation of substrate utilization and adiposity by Agrp neurons. Nature Communications 2019, 10: 311. PMID: 30659173, PMCID: PMC6338802, DOI: 10.1038/s41467-018-08239-x.Peer-Reviewed Original ResearchConceptsFat mass accumulationAgRP neuronsPositive energy balanceWhole-body substrate utilizationAgRP neuron activationHypothalamic AgRP neuronsPair-feeding conditionsSubstrate utilizationFatty acid synthaseCaloric ingestionFat utilizationNeuronal mechanismsWeight gainNeuronsMetabolic changesMass accumulationKey enzymeAdiposityAcid synthaseEnergy metabolismNeuron activationLipogenesisActivationCarbohydrate utilizationMetabolic efficiencyActivation of Agrp neurons modulates memory-related cognitive processes in mice
Zimmer MR, Schmitz AE, Dietrich MO. Activation of Agrp neurons modulates memory-related cognitive processes in mice. Pharmacological Research 2019, 141: 303-309. PMID: 30610962, PMCID: PMC6400640, DOI: 10.1016/j.phrs.2018.12.024.Peer-Reviewed Original ResearchMeSH KeywordsAgouti-Related ProteinAnimalsCognitionEatingFemaleHypothalamusMaleMaze LearningMemoryMiceNeuronsNeuropeptide YConceptsMemory-related cognitive processesCognitive processesMemory-related tasksBarnes maze taskBehavioral flexibilityAgRP neuronsSpontaneous alternation behaviorMaze taskSpatial learningY-maze testStereotyped behaviorAlternation behaviorFood intakeHypothalamic AgRP neuronsTaskNeuropeptide Y receptorsChemogenetic activationY receptorsMouse behaviorAdult miceMemoryNeuronsBehaviorLearningCritical regulator
2015
Hypothalamic Agrp Neurons Drive Stereotypic Behaviors beyond Feeding
Dietrich MO, Zimmer MR, Bober J, Horvath TL. Hypothalamic Agrp Neurons Drive Stereotypic Behaviors beyond Feeding. Cell 2015, 160: 1222-1232. PMID: 25748653, PMCID: PMC4484787, DOI: 10.1016/j.cell.2015.02.024.Peer-Reviewed Original ResearchConceptsHypothalamic AgRP neuronsAgRP neuronsNeuropeptidergic signalingReceptor signalingFunctional rolePotential therapeutic avenuesAgRP neuron activationStereotypic behaviorFeeding behaviorRepetitive behaviorsSignalingTherapeutic avenuesFood triggersAdult miceNervous systemDecreased anxietyNeuronsMinor effectActivationFood consumptionNeuron activationGoal-directed behaviorSensory informationFlexible goal-directed behaviorDisease
2014
O-GlcNAc Transferase Enables AgRP Neurons to Suppress Browning of White Fat
Ruan HB, Dietrich MO, Liu ZW, Zimmer MR, Li MD, Singh JP, Zhang K, Yin R, Wu J, Horvath TL, Yang X. O-GlcNAc Transferase Enables AgRP Neurons to Suppress Browning of White Fat. Cell 2014, 159: 306-317. PMID: 25303527, PMCID: PMC4509746, DOI: 10.1016/j.cell.2014.09.010.Peer-Reviewed Original ResearchConceptsAgRP neuronsFundamental cellular processesWhite fatN-acetylglucosamine (O-GlcNAc) modificationOrexigenic AgRP neuronsVoltage-dependent potassium channelsCellular processesGlcNAc transferaseDynamic physiological processesNuclear proteinsWhite adipose tissue browningPhysiological processesAdipose tissue browningDiet-induced obesityPhysiological relevanceTissue browningGenetic ablationBeige cellsEnergy metabolismInsulin resistanceNeuronal excitabilityPotassium channelsAdipose tissueCentral mechanismsNeuronsLeptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding
Kim JG, Suyama S, Koch M, Jin S, Argente-Arizon P, Argente J, Liu ZW, Zimmer MR, Jeong JK, Szigeti-Buck K, Gao Y, Garcia-Caceres C, Yi CX, Salmaso N, Vaccarino FM, Chowen J, Diano S, Dietrich MO, Tschöp MH, Horvath TL. Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding. Nature Neuroscience 2014, 17: 908-910. PMID: 24880214, PMCID: PMC4113214, DOI: 10.1038/nn.3725.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAstrocytesCell CountEatingExcitatory Postsynaptic PotentialsGlial Fibrillary Acidic ProteinHypothalamusImmunohistochemistryIn Situ HybridizationLeptinMaleMelanocortinsMiceMice, KnockoutMicroscopy, ElectronNerve NetNeuronsPrimary Cell CulturePro-OpiomelanocortinPulmonary Gas ExchangeReal-Time Polymerase Chain ReactionRNA, MessengerSignal Transduction