2024
546VP Deep immunoprofiling in inclusion body myositis and trajectory analysis
Roy B, DiStasio M, Hackbarth R, Bahrassa F, Joo D, Pham M, O'Connor K. 546VP Deep immunoprofiling in inclusion body myositis and trajectory analysis. Neuromuscular Disorders 2024, 43: 104441.137. DOI: 10.1016/j.nmd.2024.07.146.Peer-Reviewed Original ResearchCytotoxic T cellsInclusion body myositis patientsInclusion body myositisIdiopathic inflammatory myopathiesT cell repertoireT cellsB cell repertoireHealthy controlsB cellsExpression of cytotoxic markersIBM pathogenesisSpatial transcriptomic analysisAnalysis of peripheral blood mononuclear cellsPeripheral blood mononuclear cellsCD8 T cellsDifferentiation of cytotoxic T cellsT cell differentiation pathwayMemory B cellsBlood mononuclear cellsAbundant plasma cellsAsymmetric muscle weaknessInflammatory myopathiesCytotoxic markersTranscriptome analysis of muscle tissuesPlasma cells
2023
Human-specific epigenomic states in spermatogenesis
Liao C, Walters B, DiStasio M, Lesch B. Human-specific epigenomic states in spermatogenesis. Computational And Structural Biotechnology Journal 2023, 23: 577-588. PMID: 38274996, PMCID: PMC10809009, DOI: 10.1016/j.csbj.2023.12.037.Peer-Reviewed Original ResearchBeyond the Lab and Into the Hospital: An Outlook on the Clinical Utility of Spatial Omics Technologies
Pucciarelli D, Lu B, Zlobec I, DiStasio M. Beyond the Lab and Into the Hospital: An Outlook on the Clinical Utility of Spatial Omics Technologies. GEN Biotechnology 2023, 2: 360-371. DOI: 10.1089/genbio.2023.0030.Peer-Reviewed Original ResearchSUBCELLULAR TO TISSUE SCALE MODELING OF ISCHEMIA AND SPREADING DEPOLARIZATION
Newton A, Kelley C, Guo A, Wang J, Zink S, Distasio M, Mcdougal R, Lytton W. SUBCELLULAR TO TISSUE SCALE MODELING OF ISCHEMIA AND SPREADING DEPOLARIZATION. IBRO Neuroscience Reports 2023, 15: s792. DOI: 10.1016/j.ibneur.2023.08.1633.Peer-Reviewed Original ResearchBSBM-18 SINGLE-CELL PROFILING TUMOR-INFILTRATING IMMUNE CELLS REVEALS CXCL13+ FOLLICULAR HELPER-LIKE CD4+ T CELLS IN HUMAN BRAIN TUMORS
Lu B, Lucca L, DiStasio M, Liu Y, Pham G, Buitrago-Pocasangre N, Arnal-Estape A, Moliterno J, Chiang V, Omuro A, Hafler D. BSBM-18 SINGLE-CELL PROFILING TUMOR-INFILTRATING IMMUNE CELLS REVEALS CXCL13+ FOLLICULAR HELPER-LIKE CD4+ T CELLS IN HUMAN BRAIN TUMORS. Neuro-Oncology Advances 2023, 5: iii4-iii4. PMCID: PMC10402449, DOI: 10.1093/noajnl/vdad070.014.Peer-Reviewed Original ResearchT cell populationsT cell functionT cellsHigh-grade gliomasBrain metastasesHuman brain tumorsImmune cellsBrain tumorsNon-small cell lung cancer brain metastasesB cellsAnti-PD-1 therapy responseCell lung cancer brain metastasesLung cancer brain metastasesProductive antitumor immune responsesFollicular helper T cellsT-cell receptor sequencingTumor-infiltrating T cellsAntitumor T-cell functionCancer brain metastasesCo-inhibitory receptorsAntitumor immune responseCell receptor sequencingLonger overall survivalCell functionTertiary lymphoid structuresSporadic pituitary adenoma with somatic double-hit loss of MEN1
Hong C, Alanya H, DiStasio M, Boulware S, Rimmer R, Omay S, Erson-Omay E. Sporadic pituitary adenoma with somatic double-hit loss of MEN1. Pituitary 2023, 26: 488-494. PMID: 37438451, DOI: 10.1007/s11102-023-01336-1.Peer-Reviewed Original ResearchSingle-cell analysis reveals inflammatory interactions driving macular degeneration
Kuchroo M, DiStasio M, Song E, Calapkulu E, Zhang L, Ige M, Sheth A, Majdoubi A, Menon M, Tong A, Godavarthi A, Xing Y, Gigante S, Steach H, Huang J, Huguet G, Narain J, You K, Mourgkos G, Dhodapkar R, Hirn M, Rieck B, Wolf G, Krishnaswamy S, Hafler B. Single-cell analysis reveals inflammatory interactions driving macular degeneration. Nature Communications 2023, 14: 2589. PMID: 37147305, PMCID: PMC10162998, DOI: 10.1038/s41467-023-37025-7.Peer-Reviewed Original ResearchConceptsAge-related macular degenerationMacular degenerationNeurodegenerative diseasesNeurodegenerative conditionsLate-stage age-related macular degenerationPossible new therapeutic targetsPostmortem human retinaProgressive multiple sclerosisNew therapeutic targetsEarly phaseSingle-nucleus RNA sequencingInflammatory interactionsMultiple sclerosisInterleukin-1βDisease progressionControl retinasTherapeutic approachesGlial populationsGlial stateTherapeutic targetDisease pathogenesisRetinal diseasesAlzheimer's diseaseDiseaseHuman retinaNeuropathology of New-Onset Refractory Status Epilepticus (NORSE)
Hanin A, Cespedes J, Huttner A, Strelnikov D, Gopaul M, DiStasio M, Vezzani A, Hirsch L, Aronica E. Neuropathology of New-Onset Refractory Status Epilepticus (NORSE). Journal Of Neurology 2023, 270: 3688-3702. PMID: 37079033, DOI: 10.1007/s00415-023-11726-x.Peer-Reviewed Original ResearchConceptsNew-onset refractory status epilepticusCryptogenic new-onset refractory status epilepticusRefractory status epilepticusNeuropathology findingsStatus epilepticusSecondary neuronal injuryCryptogenic casesFebrile illnessNeuronal injuryExtensive workupNeuropathological evaluationEpilepsy surgeryPathophysiological mechanismsUnknown causePatient managementLong-term consequencesSevere formSpecific treatmentEpilepticusTissue samplesBiopsyPatientsFindings of studiesAutopsiesFindingsHigh-plex protein and whole transcriptome co-mapping at cellular resolution with spatial CITE-seq
Liu Y, DiStasio M, Su G, Asashima H, Enninful A, Qin X, Deng Y, Nam J, Gao F, Bordignon P, Cassano M, Tomayko M, Xu M, Halene S, Craft J, Hafler D, Fan R. High-plex protein and whole transcriptome co-mapping at cellular resolution with spatial CITE-seq. Nature Biotechnology 2023, 41: 1405-1409. PMID: 36823353, PMCID: PMC10567548, DOI: 10.1038/s41587-023-01676-0.Peer-Reviewed Original Research
2022
Atypical thymomas with squamoid and spindle cell features: clinicopathologic, immunohistochemical and molecular genetic study of 120 cases with long-term follow-up
Suster DI, Craig Mackinnon A, DiStasio M, Basu MK, Pihan G, Suster S. Atypical thymomas with squamoid and spindle cell features: clinicopathologic, immunohistochemical and molecular genetic study of 120 cases with long-term follow-up. Modern Pathology 2022, 35: 875-894. PMID: 35145198, DOI: 10.1038/s41379-022-01013-x.Peer-Reviewed Original ResearchConceptsSpindle cell featuresAtypical thymomaClinical courseCytokeratin AE1/AE3Completeness of resectionProgressive clinical courseHigh-grade malignancyThymic epithelial neoplasmsAE1/AE3Atypical epithelial cellsPolygonal tumor cellsCell featuresAtypical ovalThymic carcinomaOverall survivalPatient ageAnterior mediastinumMyasthenia gravisThymoma patientsAutoimmune disordersFatal outcomeRare tumorAggressive tumorsMass lesionMultiple recurrences
2019
T lymphocytes and cytotoxic astrocyte blebs correlate across autism brains
DiStasio MM, Nagakura I, Nadler MJ, Anderson MP. T lymphocytes and cytotoxic astrocyte blebs correlate across autism brains. Annals Of Neurology 2019, 86: 885-898. PMID: 31591744, PMCID: PMC7210715, DOI: 10.1002/ana.25610.Peer-Reviewed Original ResearchConceptsInnate immune responseT lymphocytesImmune responseASD brainCell-mediated injuryAutism spectrum disorderAdaptive immune cellsCSF-brain barrierMost brain regionsWhite matter vesselsPostmortem brain tissueRare genetic causeAnn NeurolLymphocytic cuffsLymphocyte numbersPathologic featuresCerebral cortexInflammatory cytokinesBrain barrierImmune cellsPostmortem brainsCerebrospinal fluidB lymphocytesEpendymal surfacePerivascular spaces
2013
Correction: Use of Frontal Lobe Hemodynamics as Reinforcement Signals to an Adaptive Controller
DiStasio M, Francis J. Correction: Use of Frontal Lobe Hemodynamics as Reinforcement Signals to an Adaptive Controller. PLOS ONE 2013, 8: 10.1371/annotation/d72e0974-f492-4fa4-a850-6dd0017395b5. PMCID: PMC3859195, DOI: 10.1371/annotation/d72e0974-f492-4fa4-a850-6dd0017395b5.Peer-Reviewed Original Research
2011
Sparse Coding of Movement-Related Neural Activity
DiStasio M, Chhatbar P, Francis J. Sparse Coding of Movement-Related Neural Activity. 2011, 1-5. DOI: 10.1109/spmb.2011.6120134.Peer-Reviewed Original ResearchMotor cortexNeural activityPrimate motor cortexNeural ensemble dataNeuronal activityMacaque monkeysMammalian brainSparse autoencoder networkAwake behaving macaque monkeysLimb movementsEnsemble activityCompression algorithmThousands of neuronsAutoencoder networkSparse autoencoderSparse codingCortexNeuronsClassifier performanceDimensionality reductionComplexity callWireless transmissionSparse basisSuch volumesFunctional data
2007
Effects of Working Memory Load on Oscillatory Power in Human Intracranial EEG
Meltzer JA, Zaveri HP, Goncharova II, Distasio MM, Papademetris X, Spencer SS, Spencer DD, Constable RT. Effects of Working Memory Load on Oscillatory Power in Human Intracranial EEG. Cerebral Cortex 2007, 18: 1843-1855. PMID: 18056698, PMCID: PMC2474453, DOI: 10.1093/cercor/bhm213.Peer-Reviewed Original Research
2006
The BioImage Suite Datatree Tool: Enabling Flexible Realtime Surgical Visualizations
DiStasio M, Vives K, Papademetris X. The BioImage Suite Datatree Tool: Enabling Flexible Realtime Surgical Visualizations. Insight Journal 2006 DOI: 10.54294/f0fw56.Peer-Reviewed Original Research