2023
Sporadic pituitary adenoma with somatic double-hit loss of MEN1
Hong C, Alanya H, DiStasio M, Boulware S, Rimmer R, Omay S, Erson-Omay E. Sporadic pituitary adenoma with somatic double-hit loss of MEN1. Pituitary 2023, 26: 488-494. PMID: 37438451, DOI: 10.1007/s11102-023-01336-1.Peer-Reviewed Original ResearchSingle-cell analysis reveals inflammatory interactions driving macular degeneration
Kuchroo M, DiStasio M, Song E, Calapkulu E, Zhang L, Ige M, Sheth A, Majdoubi A, Menon M, Tong A, Godavarthi A, Xing Y, Gigante S, Steach H, Huang J, Huguet G, Narain J, You K, Mourgkos G, Dhodapkar R, Hirn M, Rieck B, Wolf G, Krishnaswamy S, Hafler B. Single-cell analysis reveals inflammatory interactions driving macular degeneration. Nature Communications 2023, 14: 2589. PMID: 37147305, PMCID: PMC10162998, DOI: 10.1038/s41467-023-37025-7.Peer-Reviewed Original ResearchConceptsAge-related macular degenerationMacular degenerationNeurodegenerative diseasesNeurodegenerative conditionsLate-stage age-related macular degenerationPossible new therapeutic targetsPostmortem human retinaProgressive multiple sclerosisNew therapeutic targetsEarly phaseSingle-nucleus RNA sequencingInflammatory interactionsMultiple sclerosisInterleukin-1βDisease progressionControl retinasTherapeutic approachesGlial populationsGlial stateTherapeutic targetDisease pathogenesisRetinal diseasesAlzheimer's diseaseDiseaseHuman retinaNeuropathology of New-Onset Refractory Status Epilepticus (NORSE)
Hanin A, Cespedes J, Huttner A, Strelnikov D, Gopaul M, DiStasio M, Vezzani A, Hirsch L, Aronica E. Neuropathology of New-Onset Refractory Status Epilepticus (NORSE). Journal Of Neurology 2023, 270: 3688-3702. PMID: 37079033, DOI: 10.1007/s00415-023-11726-x.Peer-Reviewed Original ResearchConceptsNew-onset refractory status epilepticusCryptogenic new-onset refractory status epilepticusRefractory status epilepticusNeuropathology findingsStatus epilepticusSecondary neuronal injuryCryptogenic casesFebrile illnessNeuronal injuryExtensive workupNeuropathological evaluationEpilepsy surgeryPathophysiological mechanismsUnknown causePatient managementLong-term consequencesSevere formSpecific treatmentEpilepticusTissue samplesBiopsyPatientsFindings of studiesAutopsiesFindings
2022
Atypical thymomas with squamoid and spindle cell features: clinicopathologic, immunohistochemical and molecular genetic study of 120 cases with long-term follow-up
Suster DI, Craig Mackinnon A, DiStasio M, Basu MK, Pihan G, Suster S. Atypical thymomas with squamoid and spindle cell features: clinicopathologic, immunohistochemical and molecular genetic study of 120 cases with long-term follow-up. Modern Pathology 2022, 35: 875-894. PMID: 35145198, DOI: 10.1038/s41379-022-01013-x.Peer-Reviewed Original ResearchConceptsSpindle cell featuresAtypical thymomaClinical courseCytokeratin AE1/AE3Completeness of resectionProgressive clinical courseHigh-grade malignancyThymic epithelial neoplasmsAE1/AE3Atypical epithelial cellsPolygonal tumor cellsCell featuresAtypical ovalThymic carcinomaOverall survivalPatient ageAnterior mediastinumMyasthenia gravisThymoma patientsAutoimmune disordersFatal outcomeRare tumorAggressive tumorsMass lesionMultiple recurrences
2019
T lymphocytes and cytotoxic astrocyte blebs correlate across autism brains
DiStasio MM, Nagakura I, Nadler MJ, Anderson MP. T lymphocytes and cytotoxic astrocyte blebs correlate across autism brains. Annals Of Neurology 2019, 86: 885-898. PMID: 31591744, PMCID: PMC7210715, DOI: 10.1002/ana.25610.Peer-Reviewed Original ResearchConceptsInnate immune responseT lymphocytesImmune responseASD brainCell-mediated injuryAutism spectrum disorderAdaptive immune cellsCSF-brain barrierMost brain regionsWhite matter vesselsPostmortem brain tissueRare genetic causeAnn NeurolLymphocytic cuffsLymphocyte numbersPathologic featuresCerebral cortexInflammatory cytokinesBrain barrierImmune cellsPostmortem brainsCerebrospinal fluidB lymphocytesEpendymal surfacePerivascular spaces
2007
Effects of Working Memory Load on Oscillatory Power in Human Intracranial EEG
Meltzer JA, Zaveri HP, Goncharova II, Distasio MM, Papademetris X, Spencer SS, Spencer DD, Constable RT. Effects of Working Memory Load on Oscillatory Power in Human Intracranial EEG. Cerebral Cortex 2007, 18: 1843-1855. PMID: 18056698, PMCID: PMC2474453, DOI: 10.1093/cercor/bhm213.Peer-Reviewed Original Research