2022
Atypical thymomas with squamoid and spindle cell features: clinicopathologic, immunohistochemical and molecular genetic study of 120 cases with long-term follow-up
Suster DI, Craig Mackinnon A, DiStasio M, Basu MK, Pihan G, Suster S. Atypical thymomas with squamoid and spindle cell features: clinicopathologic, immunohistochemical and molecular genetic study of 120 cases with long-term follow-up. Modern Pathology 2022, 35: 875-894. PMID: 35145198, DOI: 10.1038/s41379-022-01013-x.Peer-Reviewed Original ResearchConceptsSpindle cell featuresAtypical thymomaClinical courseCytokeratin AE1/AE3Completeness of resectionProgressive clinical courseHigh-grade malignancyThymic epithelial neoplasmsAE1/AE3Atypical epithelial cellsPolygonal tumor cellsCell featuresAtypical ovalThymic carcinomaOverall survivalPatient ageAnterior mediastinumMyasthenia gravisThymoma patientsAutoimmune disordersFatal outcomeRare tumorAggressive tumorsMass lesionMultiple recurrences
2019
T lymphocytes and cytotoxic astrocyte blebs correlate across autism brains
DiStasio MM, Nagakura I, Nadler MJ, Anderson MP. T lymphocytes and cytotoxic astrocyte blebs correlate across autism brains. Annals Of Neurology 2019, 86: 885-898. PMID: 31591744, PMCID: PMC7210715, DOI: 10.1002/ana.25610.Peer-Reviewed Original ResearchConceptsInnate immune responseT lymphocytesImmune responseASD brainCell-mediated injuryAutism spectrum disorderAdaptive immune cellsCSF-brain barrierMost brain regionsWhite matter vesselsPostmortem brain tissueRare genetic causeAnn NeurolLymphocytic cuffsLymphocyte numbersPathologic featuresCerebral cortexInflammatory cytokinesBrain barrierImmune cellsPostmortem brainsCerebrospinal fluidB lymphocytesEpendymal surfacePerivascular spaces