2024
546VP Deep immunoprofiling in inclusion body myositis and trajectory analysis
Roy B, DiStasio M, Hackbarth R, Bahrassa F, Joo D, Pham M, O'Connor K. 546VP Deep immunoprofiling in inclusion body myositis and trajectory analysis. Neuromuscular Disorders 2024, 43: 104441.137. DOI: 10.1016/j.nmd.2024.07.146.Peer-Reviewed Original ResearchCytotoxic T cellsInclusion body myositis patientsInclusion body myositisIdiopathic inflammatory myopathiesT cell repertoireT cellsB cell repertoireHealthy controlsB cellsExpression of cytotoxic markersIBM pathogenesisSpatial transcriptomic analysisAnalysis of peripheral blood mononuclear cellsPeripheral blood mononuclear cellsCD8 T cellsDifferentiation of cytotoxic T cellsT cell differentiation pathwayMemory B cellsBlood mononuclear cellsAbundant plasma cellsAsymmetric muscle weaknessInflammatory myopathiesCytotoxic markersTranscriptome analysis of muscle tissuesPlasma cells
2023
BSBM-18 SINGLE-CELL PROFILING TUMOR-INFILTRATING IMMUNE CELLS REVEALS CXCL13+ FOLLICULAR HELPER-LIKE CD4+ T CELLS IN HUMAN BRAIN TUMORS
Lu B, Lucca L, DiStasio M, Liu Y, Pham G, Buitrago-Pocasangre N, Arnal-Estape A, Moliterno J, Chiang V, Omuro A, Hafler D. BSBM-18 SINGLE-CELL PROFILING TUMOR-INFILTRATING IMMUNE CELLS REVEALS CXCL13+ FOLLICULAR HELPER-LIKE CD4+ T CELLS IN HUMAN BRAIN TUMORS. Neuro-Oncology Advances 2023, 5: iii4-iii4. PMCID: PMC10402449, DOI: 10.1093/noajnl/vdad070.014.Peer-Reviewed Original ResearchT cell populationsT cell functionT cellsHigh-grade gliomasBrain metastasesHuman brain tumorsImmune cellsBrain tumorsNon-small cell lung cancer brain metastasesB cellsAnti-PD-1 therapy responseCell lung cancer brain metastasesLung cancer brain metastasesProductive antitumor immune responsesFollicular helper T cellsT-cell receptor sequencingTumor-infiltrating T cellsAntitumor T-cell functionCancer brain metastasesCo-inhibitory receptorsAntitumor immune responseCell receptor sequencingLonger overall survivalCell functionTertiary lymphoid structures