546VP Deep immunoprofiling in inclusion body myositis and trajectory analysis
Roy B, DiStasio M, Hackbarth R, Bahrassa F, Joo D, Pham M, O'Connor K. 546VP Deep immunoprofiling in inclusion body myositis and trajectory analysis. Neuromuscular Disorders 2024, 43: 104441.137. DOI: 10.1016/j.nmd.2024.07.146.Peer-Reviewed Original ResearchCytotoxic T cellsInclusion body myositis patientsInclusion body myositisIdiopathic inflammatory myopathiesT cell repertoireT cellsB cell repertoireHealthy controlsB cellsExpression of cytotoxic markersIBM pathogenesisSpatial transcriptomic analysisAnalysis of peripheral blood mononuclear cellsPeripheral blood mononuclear cellsCD8 T cellsDifferentiation of cytotoxic T cellsT cell differentiation pathwayMemory B cellsBlood mononuclear cellsAbundant plasma cellsAsymmetric muscle weaknessInflammatory myopathiesCytotoxic markersTranscriptome analysis of muscle tissuesPlasma cells