1994
SPECT regional cerebral blood flow alterations in naltrexone-precipitated withdrawal from buprenorphine
van Dyck C, Rosen M, Thomas H, McMahon T, Wallace E, O'Connor P, Sullivan M, Krystal J, Hoffer P, Woods S, Kosten T. SPECT regional cerebral blood flow alterations in naltrexone-precipitated withdrawal from buprenorphine. Psychiatry Research 1994, 55: 181-191. PMID: 7701033, DOI: 10.1016/0925-4927(94)90013-2.Peer-Reviewed Original ResearchConceptsRegional cerebral blood flowRegional cerebral blood flow alterationsCerebral blood flow alterationsHexamethyl propylene amine oximeOpiate-induced analgesiaBlood flow alterationsSeverity of withdrawalCerebral blood flowOpiate-dependent patientsAnterior cingulate regionsAnterior cingulate cortexSingle photon emissionPlacebo administrationAmine oximeOpiate withdrawalRCBF ratiosWithdrawal severityBlood flowCingulate cortexCingulate regionsSignificant negative correlationBuprenorphineNaltrexonePlaceboPatients
1992
A pilot trial of gepirone vs. placebo in the treatment of cocaine dependency.
Jenkins S, Warfield N, Blaine J, Cornish J, Ling W, Rosen M, Urschel H, Wesson D, Ziedonis D. A pilot trial of gepirone vs. placebo in the treatment of cocaine dependency. Psychopharmacology Bulletin 1992, 28: 21-6. PMID: 1609038.Peer-Reviewed Original ResearchConceptsGlobal Assessment ScaleAddiction Severity IndexClinical Global Impressions-Global Improvement ScaleCocaine useGlobal Improvement ScaleHamilton Rating ScaleHamilton Anxiety ScaleEvaluable patientsAdverse eventsMean dosePilot trialOpiate abuseImprovement ScaleInterim analysisTreatment groupsAssessment ScaleCocaine dependenceFavorable trendOlder ageCCS scoresStudy outcomesRating ScaleGepironeTreatment measuresSeverity Index