2024
Intrinsic connectivity demonstrates a shared role of the posterior cingulate for cue reactivity in both gambling and cocaine use disorders
Vaccaro A, Lacadie C, Potenza M. Intrinsic connectivity demonstrates a shared role of the posterior cingulate for cue reactivity in both gambling and cocaine use disorders. Addictive Behaviors 2024, 155: 108027. PMID: 38581751, PMCID: PMC11273263, DOI: 10.1016/j.addbeh.2024.108027.Peer-Reviewed Original ResearchConceptsCocaine use disorderPosterior cingulate cortexCue reactivityBehavioral addictionsUse disorderGambling disorderPosterior cingulatePosterior cingulate cortex connectivityHealthy comparison subjectsIntrinsic connectivity distributionIntervention developmentCocaine cuesFMRI taskAddictive disordersCingulate cortexComparison subjectsNeurobiological foundationsSad videosDecreased connectivityFunctional connectivityCocainePost hoc analysisAddictionRelevant to maintenanceGambling
2023
Transdiagnostic Connectome-Based Prediction of Craving
Garrison K, Sinha R, Potenza M, Gao S, Liang Q, Lacadie C, Scheinost D. Transdiagnostic Connectome-Based Prediction of Craving. American Journal Of Psychiatry 2023, 180: 445-453. PMID: 36987598, DOI: 10.1176/appi.ajp.21121207.Peer-Reviewed Original ResearchConceptsConnectome-based predictive modelingImagery conditionFunctional connectomeSelf-reported cravingStudy of motivationDefault mode networkFunctional connectivity dataIndependent samplesKey phenomenological featuresNeural signaturesTransdiagnostic sampleTransdiagnostic perspectiveMode networkMotivated behaviorCentral constructAddictive disordersHuman behaviorConnectivity dataPhenomenological featuresStrongest predictorCravingTaskSubstance use-related disordersConnectomeIndividuals
2020
Neurobiology of cue-reactivity, craving, and inhibitory control in non-substance addictive behaviors
Antons S, Brand M, Potenza MN. Neurobiology of cue-reactivity, craving, and inhibitory control in non-substance addictive behaviors. Journal Of The Neurological Sciences 2020, 415: 116952. PMID: 32534370, DOI: 10.1016/j.jns.2020.116952.Peer-Reviewed Original ResearchConceptsNon-substance addictive behaviorsAddictive behaviorsInhibitory controlPotential neurobiological mechanismsExecutive functioningSalience attributionNeurobiological foundationsSubstance use disordersNeurobiological factorsNeurobiological mechanismsBrain networksLife domainsRewarding behaviorNegative consequencesHabit formationCravingSpecific disordersNeurobiologyNeurochemical pathwaysAddictionFunctional impairmentFuture directionsSexual activityDisordersCuesDisrupted prefrontal regulation of striatum-related craving in Internet gaming disorder revealed by dynamic causal modeling: results from a cue-reactivity task
Dong GH, Wang M, Zheng H, Wang Z, Du X, Potenza MN. Disrupted prefrontal regulation of striatum-related craving in Internet gaming disorder revealed by dynamic causal modeling: results from a cue-reactivity task. Psychological Medicine 2020, 51: 1549-1561. PMID: 32102722, DOI: 10.1017/s003329172000032x.Peer-Reviewed Original ResearchConceptsInternet gaming disorderPosterior cingulate cortexRecreational game useIGD subjectsRGU subjectsNeurobiological markersGaming disorderCue-craving taskCue-reactivity taskGaming-related cuesCue-related cravingDynamic causal modelingPossible neurobiological mechanismsCognitive controlGaming cuesNeutral cuesUseful neurobiological markerPrefrontal regulationBrain responsesNeurobiological mechanismsLeft hemisphereCausal modelingCingulate cortexDirectional connectivityGame use
2019
Neurofunctional Differences Related to Methamphetamine and Sexual Cues in Men With Shorter and Longer Term Abstinence Methamphetamine Dependence
Chen S, Huang S, Yang C, Cai W, Chen H, Hao W, Liu T, Wang X, Worhunsky P, Potenza M. Neurofunctional Differences Related to Methamphetamine and Sexual Cues in Men With Shorter and Longer Term Abstinence Methamphetamine Dependence. The International Journal Of Neuropsychopharmacology 2019, 23: 135-145. PMID: 31995187, PMCID: PMC7171928, DOI: 10.1093/ijnp/pyz069.Peer-Reviewed Original ResearchConceptsHealthy comparison menFrontal cortex activationLong-term methamphetamine abstinenceSexual cuesNeutral cuesMethamphetamine cuesNeurofunctional differencesComparison menCortex activationLeft superior frontal cortexCue-related activationsNeutral visual cuesAnterior insula activationCue-reactivity taskAnterior insula responseVentromedial prefrontal cortexHealthy comparison participantsMethamphetamine abstinenceMethamphetamine dependenceFunctional magnetic resonanceWhole-brain analysisAbstinence groupSuperior frontal cortexInsula activationInsula responseAddiction severity modulates the precuneus involvement in internet gaming disorder: Functionality, morphology and effective connectivity
Dong GH, Wang M, Wang Z, Zheng H, Du X, Potenza MN. Addiction severity modulates the precuneus involvement in internet gaming disorder: Functionality, morphology and effective connectivity. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2019, 98: 109829. PMID: 31790725, DOI: 10.1016/j.pnpbp.2019.109829.Peer-Reviewed Original Research