Use of experimental medicine approaches for the development of novel psychiatric treatments based on orexin receptor modulation
Beckenstrom A, Coloma P, Dawson G, Finlayson A, Malik A, Post A, Steiner M, Potenza M. Use of experimental medicine approaches for the development of novel psychiatric treatments based on orexin receptor modulation. Neuroscience & Biobehavioral Reviews 2023, 147: 105107. PMID: 36828161, PMCID: PMC10165155, DOI: 10.1016/j.neubiorev.2023.105107.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsExperimental medicine approachPerformance outcome measuresPsychiatric disordersMedicine approachReal-world clinical practiceOrexin neuropeptide systemMarkers of efficacyPatient advocacy groupsOrexin modulationReceptor modulationSymptom evaluationReceptor modulatorsClinical studiesMood disordersPreclinical studiesNeuropeptide systemsPsychiatric treatmentAnimal modelsPathological mechanismsClinical practiceClinical researchClinical useBrain functionTranslational researchPotential target