Glutamatergic Agents for the Treatment of Cocaine Use Disorder
Hadizadeh H, Flores J, Mayerson T, Worhunsky P, Potenza M, Angarita G. Glutamatergic Agents for the Treatment of Cocaine Use Disorder. Current Behavioral Neuroscience Reports 2022, 9: 101-112. DOI: 10.1007/s40473-022-00252-1.Peer-Reviewed Original ResearchCocaine use disorderRoute of administrationGlutamatergic systemSafety profileNovel agentsUse disordersMetabotropic glutamate receptor 5 antagonistNewer beta-lactam agentsAMPA/kainate receptorsTreatment of CUDBeta-lactam agentsGood safety profileMetabotropic glutamate receptorsPromising preclinical dataReceptors/transportersChronic cocaine useGLT-1 transporterBeta-lactam antibioticsOngoing trialsPreclinical supportGlutamatergic agentsGlutamate neurotransmissionPreclinical dataClinical trialsGlutamate receptors