Synthesis and evaluation of [18F]exendin (9–39) as a potential biomarker to measure pancreatic β-cell mass
Wang Y, Lim K, Normandin M, Zhao X, Cline GW, Ding YS. Synthesis and evaluation of [18F]exendin (9–39) as a potential biomarker to measure pancreatic β-cell mass. Nuclear Medicine And Biology 2011, 39: 167-176. PMID: 22033026, PMCID: PMC4484741, DOI: 10.1016/j.nucmedbio.2011.07.011.Peer-Reviewed Original ResearchConceptsStandardized uptake valuePositron emission tomography (PET) imagingEmission Tomography ImagingPancreatic β-cell massΒ-cell massTomography imagingInsulin contentGlucagon-like peptide-1 (GLP-1) receptor antagonistGlucagon-like peptide-1Biobreeding diabetes-prone (BB-DP) ratDiabetes-prone ratsVivo positron emission tomography (PET) imagingSprague-Dawley ratsBlood glucose homeostasisReceptor antagonistGlucose homeostasisPeptide-1Time-activity curvesUptake valuePotential biomarkersHigh-resolution research tomographExendin analogsIn-111RatsPostmortem measures