2013
Creating Dynamic Images of Short-lived Dopamine Fluctuations with lp-ntPET: Dopamine Movies of Cigarette Smoking
Morris ED, Kim SJ, Sullivan JM, Wang S, Normandin MD, Constantinescu CC, Cosgrove KP. Creating Dynamic Images of Short-lived Dopamine Fluctuations with lp-ntPET: Dopamine Movies of Cigarette Smoking. Journal Of Visualized Experiments 2013, 50358. PMID: 23963311, PMCID: PMC4046621, DOI: 10.3791/50358.Peer-Reviewed Original ResearchConceptsStatistical stepsTime-varying parametersTime-varying functionModel parametersSpatial filterDecomposition techniqueKinetic model parametersConventional modelsSpatial noiseFluctuationsNew modelParametersAnalysis techniquesLp-ntPETModelConventional methodsStatistical comparisonMain stepsDynamic PET data
2011
Striatal dopamine transporter availability in unmedicated bipolar disorder
Anand A, Barkay G, Dzemidzic M, Albrecht D, Karne H, Zheng Q, Hutchins G, Normandin M, Yoder K. Striatal dopamine transporter availability in unmedicated bipolar disorder. Bipolar Disorders 2011, 13: 406-413. PMID: 21843280, DOI: 10.1111/j.1399-5618.2011.00936.x.Peer-Reviewed Original ResearchConceptsDopamine transporter availabilityBipolar disorderDopamine transporterPositron emission tomographyNeuropathology of bipolar disorderStriatal dopamine transporter availabilityEtiology of bipolar disorderMultilinear reference tissue modelUnmedicated BPD patientsBilateral dorsal caudatePresynaptic dopamine functionStructural magnetic resonance imagingStriatal binding potentialReceptor imaging studiesReference tissue modelMagnetic resonance imagingBPD patientsDopamine functionDopamine neurotransmissionDopamine systemDorsal caudateSynaptic dopamineBPD subjectsDopaminergic systemDepressive phase
2008
When What You See Isn’t What You Get: Alcohol Cues, Alcohol Administration, Prediction Error, and Human Striatal Dopamine
Yoder KK, Morris ED, Constantinescu CC, Cheng T, Normandin MD, O’Connor S, Kareken DA. When What You See Isn’t What You Get: Alcohol Cues, Alcohol Administration, Prediction Error, and Human Striatal Dopamine. Alcohol Clinical And Experimental Research 2008, 33: 139-149. PMID: 18976347, PMCID: PMC2905874, DOI: 10.1111/j.1530-0277.2008.00821.x.Peer-Reviewed Original ResearchConceptsRinger's lactate infusionAlcohol infusionLactate infusionAlcohol administrationAlcohol-related cuesConditioned cuesStriatal DA concentrationsStriatal DA releaseLactate solutionMesolimbic dopamine systemMidbrain dopamine neuronsRinger's lactate solutionStriatal DAHuman alcohol consumptionDA releaseStriatal dopamineAlcohol drinkingDopamine neuronsDopaminergic responseNeutral cuesBaseline scanHealthy humansPET scansDopamine systemAlcohol consumption
2005
ntPET: A New Application of PET Imaging for Characterizing the Kinetics of Endogenous Neurotransmitter Release
Morris ED, Yoder KK, Wang C, Normandin MD, Zheng QH, Mock B, Raymond F, Froehlich JC. ntPET: A New Application of PET Imaging for Characterizing the Kinetics of Endogenous Neurotransmitter Release. Molecular Imaging 2005, 4: 7290.2005.05130. PMID: 16285909, DOI: 10.2310/7290.2005.05130.Peer-Reviewed Original ResearchConceptsNeurotransmitter releaseArterial blood samplingEndogenous neurotransmitter releasePositron emission tomographyEndogenous dopamineDrug treatmentRat striatumBlood samplingBlood flowEmission tomographyFalse-positive responsesD3 receptor ligandsDopamine concentrationsPET imagingReceptor ligandsNoninvasive assayTracer kinetic modelReference regionStimulus conditionsDopamine