2020
PET imaging of neurotransmission using direct parametric reconstruction
Petibon Y, Alpert N, Ouyang J, Pizzagalli D, Cusin C, Fava M, Fakhri G, Normandin M. PET imaging of neurotransmission using direct parametric reconstruction. NeuroImage 2020, 221: 117154. PMID: 32679252, PMCID: PMC7800040, DOI: 10.1016/j.neuroimage.2020.117154.Peer-Reviewed Original ResearchMeSH KeywordsBrainComputer SimulationHumansNeuroimagingPositron-Emission TomographyRadiopharmaceuticalsSynaptic TransmissionConceptsSignal-to-noise ratioImage reconstructionPositron emission tomography image reconstructionLow signal-to-noise ratioPoisson log-likelihood functionScattered coincidencesDetector sensitivityPET sinogramsStatistical fluctuationsEstimate parametric imagesGradient-based optimizationParametric reconstructionLog-likelihood functionEffects of head movementVoxel scalePositron emission tomographySimplified reference region modelActivity concentration data
2016
Pharmacokinetic Evaluation of the Tau PET Radiotracer 18F-T807 (18F-AV-1451) in Human Subjects
Wooten D, Guehl N, Verwer E, Shoup T, Yokell D, Zubcevik N, Vasdev N, Zafonte R, Johnson K, Fakhri G, Normandin M. Pharmacokinetic Evaluation of the Tau PET Radiotracer 18F-T807 (18F-AV-1451) in Human Subjects. Journal Of Nuclear Medicine 2016, 58: 484-491. PMID: 27660144, PMCID: PMC5334185, DOI: 10.2967/jnumed.115.170910.Peer-Reviewed Original ResearchConceptsDistribution volume ratioTraumatic brain injuryMetabolite-corrected arterial input functionPET imagingPlasma radioactivity concentrationsTemporal cortexDynamic PET imagesTotal volume of distributionVolume of distributionTraumatic brain injury subjectsMesial temporal cortexArterial blood samplesPosterior cingulate gyrusFocal uptakeSUV ratioHuman subjectsArterial input functionPosterior corpus callosumBolus injectionPharmacokinetic evaluation
2012
Selection of weighting factors for quantification of PET radioligand binding using simplified reference tissue models with noisy input functions
Normandin M, Koeppe R, Morris E. Selection of weighting factors for quantification of PET radioligand binding using simplified reference tissue models with noisy input functions. Physics In Medicine And Biology 2012, 57: 609-629. PMID: 22241524, PMCID: PMC3361066, DOI: 10.1088/0031-9155/57/3/609.Peer-Reviewed Original Research
2011
A linear model for estimation of neurotransmitter response profiles from dynamic PET data
Normandin MD, Schiffer WK, Morris ED. A linear model for estimation of neurotransmitter response profiles from dynamic PET data. NeuroImage 2011, 59: 2689-2699. PMID: 21767654, PMCID: PMC3702051, DOI: 10.1016/j.neuroimage.2011.07.002.Peer-Reviewed Original Research
2007
Estimating neurotransmitter kinetics with ntPET: A simulation study of temporal precision and effects of biased data
Normandin MD, Morris ED. Estimating neurotransmitter kinetics with ntPET: A simulation study of temporal precision and effects of biased data. NeuroImage 2007, 39: 1162-1179. PMID: 18023364, PMCID: PMC2271120, DOI: 10.1016/j.neuroimage.2007.09.046.Peer-Reviewed Original Research
2006
Temporal Resolution of ntPET Using Either Arterial or Reference Region-Derived Plasma Input Functions
Normandin M, Morris E. Temporal Resolution of ntPET Using Either Arterial or Reference Region-Derived Plasma Input Functions. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2006, 2006: 2005-2008. PMID: 17946491, DOI: 10.1109/iembs.2006.259716.Peer-Reviewed Original Research