2017
Frontostriatal and Dopamine Markers of Individual Differences in Reinforcement Learning: A Multi-modal Investigation
Kaiser R, Treadway M, Wooten D, Kumar P, Goer F, Murray L, Beltzer M, Pechtel P, Whitton A, Cohen A, Alpert N, Fakhri G, Normandin M, Pizzagalli D. Frontostriatal and Dopamine Markers of Individual Differences in Reinforcement Learning: A Multi-modal Investigation. Cerebral Cortex 2017, 28: 4281-4290. PMID: 29121332, PMCID: PMC6454484, DOI: 10.1093/cercor/bhx281.Peer-Reviewed Original ResearchConceptsDA transporterRL behaviourVentral striatumDA clearanceFunctional connectivityBinding potentialLevel of neurocognitive functioningIncreased intrinsic functional connectivityMulti-modal neuroimaging studiesResting-state functional connectivityPhasic DA activityStriatal DA transporterIntrinsic functional connectivityReinforcement learning behaviorMulti-modal investigationsFrontostriatal circuitsFrontostriatal connectivityFrontostriatal regionsOrbitofrontal cortexDA activityNeuroimaging studiesOrbitofrontal regionsDopamine markersNeurocognitive functionDopamine
2016
Differences in IV alcohol-induced dopamine release in the ventral striatum of social drinkers and nontreatment-seeking alcoholics
Yoder K, Albrecht D, Dzemidzic M, Normandin M, Federici L, Graves T, Herring C, Hile K, Walters J, Liang T, Plawecki M, O'Connor S, Kareken D. Differences in IV alcohol-induced dopamine release in the ventral striatum of social drinkers and nontreatment-seeking alcoholics. Drug And Alcohol Dependence 2016, 160: 163-169. PMID: 26832934, PMCID: PMC5074339, DOI: 10.1016/j.drugalcdep.2016.01.001.Peer-Reviewed Original ResearchConceptsSample of social drinkersNontreatment-seeking alcoholicsSocial drinkersVentral striatumDopamine releaseAlcohol intoxicationAlcohol-induced dopamine releaseVoxel-wise binding potentialTarget breath alcohol concentrationEffects of alcohol intoxicationRight ventral striatumInduce dopamine releaseStriatal DA systemIntravenous alcohol infusionAlcohol use disorderResponse to alcoholBreath alcohol concentrationDA responseStriatal dopamineDA systemTarget BrACAlcohol clampUse disorderDependent drinkersAlcohol infusion