2021
In vivo imaging of mGlu5 receptor expression in humans with Fragile X Syndrome towards development of a potential biomarker
Mody M, Petibon Y, Han P, Kuruppu D, Ma C, Yokell D, Neelamegam R, Normandin M, Fakhri G, Brownell A. In vivo imaging of mGlu5 receptor expression in humans with Fragile X Syndrome towards development of a potential biomarker. Scientific Reports 2021, 11: 15897. PMID: 34354107, PMCID: PMC8342610, DOI: 10.1038/s41598-021-94967-y.Peer-Reviewed Original ResearchConceptsFragile X syndromeFragile X mental retardation proteinX syndromeLoss of fragile X mental retardation proteinMGlu5 receptor expressionMetabotropic glutamate subtype 5 receptorsDrug occupancy studiesSignificant group differencesFragile X mental retardationHealthy controlsAnterior cingulateMGluR5 availabilityVisuospatial processingMGlu5 receptorsOlfactory cortexBrain areasGroup differencesRetardation proteinGlutamate signalingImages of maleNeurodevelopmental disordersExcessive glutamate signalingGender-matched controlsDisordersMGluR5
2012
Positron Emission Tomography Shows Elevated Cannabinoid CB 1 Receptor Binding in Men with Alcohol Dependence
Neumeister A, Normandin MD, Murrough JW, Henry S, Bailey CR, Luckenbaugh DA, Tuit K, Zheng M, Galatzer‐Levy I, Sinha R, Carson RE, Potenza MN, Huang Y. Positron Emission Tomography Shows Elevated Cannabinoid CB 1 Receptor Binding in Men with Alcohol Dependence. Alcohol Clinical And Experimental Research 2012, 36: 2104-2109. PMID: 22551199, PMCID: PMC3418442, DOI: 10.1111/j.1530-0277.2012.01815.x.Peer-Reviewed Original ResearchConceptsPositron emission tomographyAlcohol dependenceBrain CBTime-activity curvesEmission tomographyBody mass indexHealthy control menRecent therapeutic developmentsMedication-free participantsPosterior cingulate cortexCurrent study designPreclinical evidenceSmoking statusMass indexControl menReceptor densityLast drinkECB functionCingulate cortexBrain regionsSelective radiotracerEndogenous CBOrbitofrontal cortexPeripheral measuresStudy design