2016
Differences in IV alcohol-induced dopamine release in the ventral striatum of social drinkers and nontreatment-seeking alcoholics
Yoder K, Albrecht D, Dzemidzic M, Normandin M, Federici L, Graves T, Herring C, Hile K, Walters J, Liang T, Plawecki M, O'Connor S, Kareken D. Differences in IV alcohol-induced dopamine release in the ventral striatum of social drinkers and nontreatment-seeking alcoholics. Drug And Alcohol Dependence 2016, 160: 163-169. PMID: 26832934, PMCID: PMC5074339, DOI: 10.1016/j.drugalcdep.2016.01.001.Peer-Reviewed Original ResearchConceptsSample of social drinkersNontreatment-seeking alcoholicsSocial drinkersVentral striatumDopamine releaseAlcohol intoxicationAlcohol-induced dopamine releaseVoxel-wise binding potentialTarget breath alcohol concentrationEffects of alcohol intoxicationRight ventral striatumInduce dopamine releaseStriatal DA systemIntravenous alcohol infusionAlcohol use disorderResponse to alcoholBreath alcohol concentrationDA responseStriatal dopamineDA systemTarget BrACAlcohol clampUse disorderDependent drinkersAlcohol infusion
2011
Imaging of alcohol‐induced dopamine release in rats:Preliminary findings with [11C]raclopride PET
Sullivan JM, Risacher SL, Normandin MD, Yoder KK, Froehlich JC, Morris ED. Imaging of alcohol‐induced dopamine release in rats:Preliminary findings with [11C]raclopride PET. Synapse 2011, 65: 929-937. PMID: 21308803, PMCID: PMC3130821, DOI: 10.1002/syn.20921.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsBrainCarbon IsotopesCentral Nervous System DepressantsDopamineDopamine AntagonistsDose-Response Relationship, DrugEthanolMalePositron-Emission TomographyProtein BindingRacloprideRatsRats, WistarConceptsPositron emission tomographyBlood alcohol concentrationSmall animal positron emission tomographyRat striatumAnimal positron emission tomographyP ratsAlcohol-induced dopamine releaseSignificant alcohol-induced decreaseAlcohol-induced decreaseBlood alcohol levelsLateral saphenous veinAlcohol-preferring ratsAnimals 10 minSystemic alcoholDA releaseMicrodialysis studyStriatal dopamineAlcohol administrationSaphenous veinMale WistarDopamine releaseLarge cohortExtracellular dopamineBlood samplesReceptor availability
2007
Estimating neurotransmitter kinetics with ntPET: A simulation study of temporal precision and effects of biased data
Normandin MD, Morris ED. Estimating neurotransmitter kinetics with ntPET: A simulation study of temporal precision and effects of biased data. NeuroImage 2007, 39: 1162-1179. PMID: 18023364, PMCID: PMC2271120, DOI: 10.1016/j.neuroimage.2007.09.046.Peer-Reviewed Original Research