2021
Synthesis and Characterization of [18F]JNJ-46356479 as the First 18F-Labeled PET Imaging Ligand for Metabotropic Glutamate Receptor 2
Yuan G, Guehl N, Zheng B, Qu X, Moon S, Dhaynaut M, Shoup T, Afshar S, Kang H, Zhang Z, El Fakhri G, Normandin M, Brownell A. Synthesis and Characterization of [18F]JNJ-46356479 as the First 18F-Labeled PET Imaging Ligand for Metabotropic Glutamate Receptor 2. Molecular Imaging And Biology 2021, 23: 527-536. PMID: 33559035, PMCID: PMC8277681, DOI: 10.1007/s11307-021-01586-0.Peer-Reviewed Original ResearchConceptsNon-human primatesIn vivo PET imaging studiesNucleus accumbensGlutamate receptor 2PET imaging ligandsImaging ligandsParietal cortexBrain regionsPET imaging studiesPET radioligandIn vivo PET imaging experimentsVolume of distributionMGluR2C57BL/6 J micePET imaging experimentsPET studiesBrainSprague-Dawley ratsAlzheimer's diseaseBrain permeabilityPre-treatment studyImaging studiesDisordersRat studiesReversible kinetics
2020
Dependence of fluorodeoxyglucose (FDG) uptake on cell cycle and dry mass: a single-cell study using a multi-modal radiography platform
Sung Y, Tetrault M, Takahashi K, Ouyang J, Pratx G, Fakhri G, Normandin M. Dependence of fluorodeoxyglucose (FDG) uptake on cell cycle and dry mass: a single-cell study using a multi-modal radiography platform. Scientific Reports 2020, 10: 4280. PMID: 32152343, PMCID: PMC7062696, DOI: 10.1038/s41598-020-59515-0.Peer-Reviewed Original ResearchMeSH KeywordsCell CycleCell DivisionCell ProliferationFluorodeoxyglucose F18HeLa CellsHumansPositron-Emission TomographyRadiopharmaceuticalsSingle-Cell AnalysisConceptsCell divisionHeLa cellsDry massM phaseCell dry massCancer compared to normal tissuesCell cycle phasesHouse-keeping proteinsSingle-cell studiesSingle-cell levelIncreased dry massProliferation indexCell cycleG1 phaseProportion of cellsHigher glucose uptakeFluorodeoxyglucose uptakeGlucose uptakeHeLaUptake rate
2008
A rat head holder for simultaneous scanning of two rats in small animal PET scanners: Design, construction, feasibility testing and kinetic validation
Cheng TE, Yoder KK, Normandin MD, Risacher SL, Converse AK, Hampel JA, Miller MA, Morris ED. A rat head holder for simultaneous scanning of two rats in small animal PET scanners: Design, construction, feasibility testing and kinetic validation. Journal Of Neuroscience Methods 2008, 176: 24-33. PMID: 18824025, PMCID: PMC3725621, DOI: 10.1016/j.jneumeth.2008.08.031.Peer-Reviewed Original Research