Locus coeruleus integrity as a proxy of initial tau burden: in vivo versus ex vivo observations
Jacobs H, Becker A, Kwong K, Engels N, Prokopiou P, Papp K, Properzi M, Hampton O, Sanchez J, Rentz D, Fakhri G, Normandin M, Bennett D, Sperling R, Johnson K. Locus coeruleus integrity as a proxy of initial tau burden: in vivo versus ex vivo observations. Alzheimer's & Dementia 2021, 17 DOI: 10.1002/alz.056391.Peer-Reviewed Original ResearchHarvard Aging Brain StudyMini-Mental State ExaminationLC integrityLocus coeruleusMini-Mental State Examination scoreNeuronal densityTangle densityLocus coeruleus integrityAging Brain StudyTau pathologyAlzheimer's diseaseAD-related processesVertex-wiseTemporal regionsBraak stageLC measurementsMini-MentalMCI/AD patientsState ExaminationBrain studiesPiB-PET imagingTau-PETPET measurementsPiB-PETTangle burdenThe cortical origin and initial spread of medial temporal tauopathy in Alzheimer’s disease assessed with positron emission tomography
Sanchez J, Becker J, Jacobs H, Hanseeuw B, Jiang S, Schultz A, Properzi M, Katz S, Beiser A, Satizabal C, O'Donnell A, DeCarli C, Killiany R, El Fakhri G, Normandin M, Gómez-Isla T, Quiroz Y, Rentz D, Sperling R, Seshadri S, Augustinack J, Price J, Johnson K. The cortical origin and initial spread of medial temporal tauopathy in Alzheimer’s disease assessed with positron emission tomography. Science Translational Medicine 2021, 13 PMID: 33472953, PMCID: PMC7978042, DOI: 10.1126/scitranslmed.abc0655.Peer-Reviewed Original ResearchConceptsPositron emission tomographyTemporal lobeMedial temporal lobe tauAlzheimer's diseaseMedial temporal lobeStudy of normal agingAssociated with baseline measuresMolecular positron emission tomographyTau-PET signalDegree of clinical impairmentEmission tomographyModel of Alzheimer's diseaseTemporal lobe anatomyCognitive declineClinical impairmentNormal agingAdult participantsStudy of AgingRhinal sulcusBrain pathologyExtratemporal regionsPET measurementsLongitudinal studyTau progressionClinically normal people