2023
Association of Novelty-Related Locus Coeruleus Function With Entorhinal Tau Deposition and Memory Decline in Preclinical Alzheimer Disease
Prokopiou P, Engels-Domínguez N, Schultz A, Sepulcre J, Koops E, Papp K, Marshall G, Normandin M, El Fakhri G, Rentz D, Sperling R, Johnson K, Jacobs H. Association of Novelty-Related Locus Coeruleus Function With Entorhinal Tau Deposition and Memory Decline in Preclinical Alzheimer Disease. Neurology 2023, 101: e1206-e1217. PMID: 37491329, PMCID: PMC10516269, DOI: 10.1212/wnl.0000000000207646.Peer-Reviewed Original ResearchConceptsLC activityMemory declineLocus coeruleusCognitive declineEC tauHarvard Aging Brain StudyHuman neuroimaging studiesSteeper memory declineNoradrenergic brainstem nucleiLongitudinal cognitive dataFunctional MRI dataTau depositionAging Brain StudyPreclinical Alzheimer's diseaseTau progressionCortical tau depositionElevated beta-amyloidInterventions promoting resilienceMild cognitive impairmentExecutive dysfunctionExecutive functionNeuroimaging studiesTau spreadingTemporal cortexCognitive composite
2017
Frontostriatal and Dopamine Markers of Individual Differences in Reinforcement Learning: A Multi-modal Investigation
Kaiser R, Treadway M, Wooten D, Kumar P, Goer F, Murray L, Beltzer M, Pechtel P, Whitton A, Cohen A, Alpert N, Fakhri G, Normandin M, Pizzagalli D. Frontostriatal and Dopamine Markers of Individual Differences in Reinforcement Learning: A Multi-modal Investigation. Cerebral Cortex 2017, 28: 4281-4290. PMID: 29121332, PMCID: PMC6454484, DOI: 10.1093/cercor/bhx281.Peer-Reviewed Original ResearchConceptsDA transporterRL behaviourVentral striatumDA clearanceFunctional connectivityBinding potentialLevel of neurocognitive functioningIncreased intrinsic functional connectivityMulti-modal neuroimaging studiesResting-state functional connectivityPhasic DA activityStriatal DA transporterIntrinsic functional connectivityReinforcement learning behaviorMulti-modal investigationsFrontostriatal circuitsFrontostriatal connectivityFrontostriatal regionsOrbitofrontal cortexDA activityNeuroimaging studiesOrbitofrontal regionsDopamine markersNeurocognitive functionDopamine