2012
In Vivo Imaging of Endogenous Pancreatic β-Cell Mass in Healthy and Type 1 Diabetic Subjects Using 18F-Fluoropropyl-Dihydrotetrabenazine and PET
Normandin MD, Petersen KF, Ding YS, Lin SF, Naik S, Fowles K, Skovronsky DM, Herold KC, McCarthy TJ, Calle RA, Carson RE, Treadway JL, Cline GW. In Vivo Imaging of Endogenous Pancreatic β-Cell Mass in Healthy and Type 1 Diabetic Subjects Using 18F-Fluoropropyl-Dihydrotetrabenazine and PET. Journal Of Nuclear Medicine 2012, 53: 908-916. PMID: 22573821, PMCID: PMC3737743, DOI: 10.2967/jnumed.111.100545.Peer-Reviewed Original ResearchConceptsType 1 diabetes mellitusVesicular monoamine transporter type 2Pancreatic β-cell massStandardized uptake valueΒ-cell massDiabetes mellitusUptake valueType 1 diabetic subjectsΒ-cell densityHealthy control subjectsInsulin secretion capacityΒ-cell functionPathophysiology of diabetesTransporter type 2Nondisplaceable uptakeDiabetic subjectsControl subjectsDisease progressionClinical assessmentVMAT2 bindingRenal cortexTotal pancreasDTBZ PETEarly diagnosisInjected dose
2007
Heterogeneous Effects of Alcohol on Dopamine Release in the Striatum: A PET Study
Yoder KK, Constantinescu CC, Kareken DA, Normandin MD, Cheng T, O'Connor SJ, Morris ED. Heterogeneous Effects of Alcohol on Dopamine Release in the Striatum: A PET Study. Alcohol Clinical And Experimental Research 2007, 31: 965-973. PMID: 17428296, DOI: 10.1111/j.1530-0277.2007.00390.x.Peer-Reviewed Original ResearchConceptsAnatomic extentDA responseDA releasePositron emission tomographyAlcohol-related behaviorsDopaminergic responseDopamine releaseD2/D3 receptor availabilityStriatal dopamine releaseHealthy control subjectsStriatal DA responseStriatal binding potentialD3 receptor availabilityTime-Line FollowSubjective responsesVoxel-wise t-testsEffects of alcoholControl subjectsAlcohol infusionPET scansReceptor availabilityEmission tomographyLack of reportsDA involvementPET studies