2023
Grading system for medullary thyroid carcinoma; an institutional experience
Podany P, Meiklejohn K, Garritano J, Holt E, Barbieri A, Prasad M, Gilani S. Grading system for medullary thyroid carcinoma; an institutional experience. Annals Of Diagnostic Pathology 2023, 64: 152112. PMID: 36736129, DOI: 10.1016/j.anndiagpath.2023.152112.Peer-Reviewed Original ResearchConceptsMedullary thyroid carcinomaTwo-tier grading systemDistant metastasisNuclear pleomorphismGrading systemNodal diseaseOverall survivalVascular invasionMTC casesThyroid carcinomaMedullary thyroid carcinoma casesMultivariate Cox regressionThyroid carcinoma casesCohort of casesRisk stratificationCox regressionTumor gradePathology reportsCarcinoma casesInstitutional experienceThyroid malignancyTumor fibrosisHG groupProminent nucleoliRare type
2018
Comprehensive Genetic Analysis of Follicular Thyroid Carcinoma Predicts Prognosis Independent of Histology
Nicolson NG, Murtha TD, Dong W, Paulsson JO, Choi J, Barbieri AL, Brown TC, Kunstman JW, Larsson C, Prasad ML, Korah R, Lifton RP, Juhlin CC, Carling T. Comprehensive Genetic Analysis of Follicular Thyroid Carcinoma Predicts Prognosis Independent of Histology. The Journal Of Clinical Endocrinology & Metabolism 2018, 103: 2640-2650. PMID: 29726952, DOI: 10.1210/jc.2018-00277.Peer-Reviewed Original ResearchConceptsFollicular thyroid carcinomaThyroid carcinomaMutation burdenWorse disease-specific survivalDisease-specific survivalDifferent histopathological subtypesWorld Health Organization guidelinesSomatic mutationsNonsynonymous somatic mutationsHealth Organization guidelinesTotal mutation burdenIndependent predictorsWorse prognosisHistopathological subtypesPatient outcomesHistopathological classificationInvasive subtypesClinicopathologic parametersMutational burdenSurvival analysisSomatic copy number alterationsCopy number alterationsSubtypesOrganization guidelinesMore subclones
2017
Metastatic thyroid carcinoma without identifiable primary tumor within the thyroid gland: a retrospective study of a rare phenomenon
Xu B, Scognamiglio T, Cohen PR, Prasad ML, Hasanovic A, Tuttle RM, Katabi N, Ghossein RA. Metastatic thyroid carcinoma without identifiable primary tumor within the thyroid gland: a retrospective study of a rare phenomenon. Human Pathology 2017, 65: 133-139. PMID: 28552827, PMCID: PMC5571865, DOI: 10.1016/j.humpath.2017.05.013.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBiomarkers, TumorCarcinomaCarcinoma, PapillaryCell DifferentiationDNA Mutational AnalysisFemaleGenetic Predisposition to DiseaseHumansImmunohistochemistryLymphatic MetastasisMaleMiddle AgedMutationNeoplasm GradingNeoplasms, Unknown PrimaryPhenotypeProto-Oncogene Proteins B-rafRetrospective StudiesThyroid Cancer, PapillaryThyroid Carcinoma, AnaplasticThyroid NeoplasmsConceptsPapillary thyroid carcinomaIdentifiable primary tumorThyroid carcinomaAnaplastic thyroid carcinomaMetastatic diseasePrimary tumorThyroid glandMetastatic papillary thyroid carcinomaEvidence of recurrenceMetastatic nodal diseaseMetastatic thyroid carcinomaTall cell variantBRAF V600E immunohistochemistryThyroid primaryNodal diseaseNeck compartmentDistant metastasisPathologic featuresRetrospective studyAnaplastic carcinomaUnknown causeMost tumorsCarcinomaPatientsThyroid tumors
2016
Recurrent Mutations of Chromatin-Remodeling Genes and Kinase Receptors in Pheochromocytomas and Paragangliomas
Toledo RA, Qin Y, Cheng ZM, Gao Q, Iwata S, Silva GM, Prasad M, Ocal IT, Rao S, Aronin N, Barontini M, Bruder J, Reddick RL, Chen Y, Aguiar RC, Dahia PL. Recurrent Mutations of Chromatin-Remodeling Genes and Kinase Receptors in Pheochromocytomas and Paragangliomas. Clinical Cancer Research 2016, 22: 2301-2310. PMID: 26700204, PMCID: PMC4854762, DOI: 10.1158/1078-0432.ccr-15-1841.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdrenal Gland NeoplasmsAdultAgedCarcinoma, NeuroendocrineChildChromatinChromatin Assembly and DisassemblyC-Mer Tyrosine KinaseExomeFemaleGerm-Line MutationGiant Cell Tumor of BoneHistone DemethylasesHistone MethyltransferasesHistone-Lysine N-MethyltransferaseHistonesHumansMaleMiddle AgedParagangliomaPheochromocytomaThyroid NeoplasmsYoung AdultConceptsHistone methylation analysisAnalysis of mutantsChromatin-remodeling genesChromatin remodelingHistone demethylasesTranscriptome sequencingFrequent genetic eventKinase geneMolecular basisPPGL susceptibility genesGenesGenetic eventsNeural crest originMethylation analysisSusceptibility genesNew cancer syndromeMost PPGLsMutationsSomatic mutationsProtein expressionCell linesDomain mutationsFGFR1 mutationsWestern blottingDriver mutationsNTRK fusion oncogenes in pediatric papillary thyroid carcinoma in northeast United States
Prasad ML, Vyas M, Horne MJ, Virk RK, Morotti R, Liu Z, Tallini G, Nikiforova MN, Christison-Lagay ER, Udelsman R, Dinauer CA, Nikiforov YE. NTRK fusion oncogenes in pediatric papillary thyroid carcinoma in northeast United States. Cancer 2016, 122: 1097-1107. PMID: 26784937, DOI: 10.1002/cncr.29887.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentCarcinomaCarcinoma, PapillaryChildDNA Mutational AnalysisFemaleHigh-Throughput Nucleotide SequencingHumansMaleMutationNew EnglandNuclear Pore Complex ProteinsOncogene Proteins, FusionProto-Oncogene MasProto-Oncogene ProteinsProto-Oncogene Proteins B-rafProto-Oncogene Proteins c-etsProto-Oncogene Proteins c-retReceptor, trkAReceptor, trkCRepressor ProteinsReverse Transcriptase Polymerase Chain ReactionThyroid Cancer, PapillaryThyroid Neoplasms
2015
C-Cell Neoplasia in Asymptomatic Carriers of RET Mutation in Extracellular Cysteine-Rich and Intracellular Tyrosine Kinase Domain
Abi-Raad R, Virk RK, Dinauer CA, Prasad A, Morotti RA, Breuer CK, Sosa JA, Udelsman R, Rivkees SA, Prasad ML. C-Cell Neoplasia in Asymptomatic Carriers of RET Mutation in Extracellular Cysteine-Rich and Intracellular Tyrosine Kinase Domain. Human Pathology 2015, 46: 1121-1128. PMID: 26033033, DOI: 10.1016/j.humpath.2015.04.011.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultCarcinoma, NeuroendocrineChildChild, PreschoolFemaleGenetic Predisposition to DiseaseGerm-Line MutationHeterozygoteHumansInfantMaleMiddle AgedMultiple Endocrine NeoplasiaProtein Structure, TertiaryProto-Oncogene MasProto-Oncogene Proteins c-retThyroid NeoplasmsYoung AdultConceptsMedullary thyroid carcinomaMultiple endocrine neoplasia type 2C-cell hyperplasiaAsymptomatic carriersC-cell neoplasiaRET mutationsMTC familiesHigh-risk RET mutationsIntracellular tyrosine kinase domainTyrosine kinase domainC-cell diseaseC-cell pathologyLymph node metastasisCodon 918 mutationYounger median ageReceptor tyrosine kinase proteinTotal thyroidectomyProgressive diseaseMedian ageNode metastasisThyroid carcinomaType 2Germline mutationsTyrosine kinase proteinFormer group
2014
Morphology predicts BRAFV600E mutation in papillary thyroid carcinoma: an interobserver reproducibility study
Virk RK, Theoharis CG, Prasad A, Chhieng D, Prasad ML. Morphology predicts BRAFV600E mutation in papillary thyroid carcinoma: an interobserver reproducibility study. Virchows Archiv 2014, 464: 435-442. PMID: 24549591, DOI: 10.1007/s00428-014-1552-3.Peer-Reviewed Original Research
2009
Insulin-Like Growth Factor mRNA Binding Protein 3 (IMP3) is Differentially Expressed in Benign and Malignant Follicular Patterned Thyroid Tumors
Slosar M, Vohra P, Prasad M, Fischer A, Quinlan R, Khan A. Insulin-Like Growth Factor mRNA Binding Protein 3 (IMP3) is Differentially Expressed in Benign and Malignant Follicular Patterned Thyroid Tumors. Endocrine Pathology 2009, 20: 149-157. PMID: 19449140, DOI: 10.1007/s12022-009-9079-x.Peer-Reviewed Original ResearchConceptsHürthle cell carcinomaPapillary thyroid carcinomaHürthle cell adenomaFollicular carcinomaGraves' diseaseHashimoto's thyroiditisColloid nodulesFollicular adenomaIMP3 expressionThyroid carcinomaStrong stainingInsulin-like growth factor mRNAThyroid lesionsProtein 3Conventional papillary thyroid carcinomaPathologic tumor characteristicsInsulin-like growth factor IIResidual thyroid tissueSurgical pathology archivesBinding protein 3Thyroid follicular lesionsGrowth factor IIGrowth factor mRNATumor characteristicsUterine cervix
2001
Gene expression in papillary thyroid carcinoma reveals highly consistent profiles
Huang Y, Prasad M, Lemon W, Hampel H, Wright F, Kornacker K, LiVolsi V, Frankel W, Kloos R, Eng C, Pellegata N, de la Chapelle A. Gene expression in papillary thyroid carcinoma reveals highly consistent profiles. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 15044-15049. PMID: 11752453, PMCID: PMC64980, DOI: 10.1073/pnas.251547398.Peer-Reviewed Original ResearchConceptsNumerous additional genesExtracellular matrix proteinsTranscriptase-PCRFunction-related proteinsAdditional genesSpecific molecular changesGene expressionDNA arraysExpression profilesTumor suppressorMatrix proteinsMolecular biologyGenesMolecular pathwaysReverse transcriptase-PCRPTC tissuesCITED1Molecular changesProteinODZ1Concordant expressionHigh expressionNormal thyroid tissueExpressionPapillary thyroid carcinoma