Early tumor detection afforded by in vivo imaging of near-infrared II fluorescence
Tao Z, Dang X, Huang X, Muzumdar MD, Xu ES, Bardhan NM, Song H, Qi R, Yu Y, Li T, Wei W, Wyckoff J, Birrer MJ, Belcher AM, Ghoroghchian PP. Early tumor detection afforded by in vivo imaging of near-infrared II fluorescence. Biomaterials 2017, 134: 202-215. PMID: 28482280, DOI: 10.1016/j.biomaterials.2017.04.046.Peer-Reviewed Original ResearchConceptsExogenous contrast agentsLanthanide nanoparticlesUnique nanoparticlesBiodegradable diblock copolymerRed fluorescent proteinOptical signalNIR-IINanoparticlesOVCAR-8 ovarian cancer cellsTumor accumulationTissue autofluorescenceOrganic fluorophoresContrast agentsTissue penetrationEarly tumor detectionFluorescent agentsOptical excitationEnhanced sensitivityIntrinsic reporterFluorescent proteinAccurate detectionNIRTumor detectionLuciferaseDiblock copolymers