2024
TLR8‐activating miR‐146a‐3p is an intermediate signal contributing to fetal membrane inflammation in response to bacterial LPS
Georges H, Cassin C, Tong M, Abrahams V. TLR8‐activating miR‐146a‐3p is an intermediate signal contributing to fetal membrane inflammation in response to bacterial LPS. Immunology 2024, 172: 577-587. PMID: 38631842, PMCID: PMC11223956, DOI: 10.1111/imm.13794.Peer-Reviewed Original ResearchMiR-146a-3pPreterm birthFetal membranesToll-like receptorsExpression of miR-146a-3pLipopolysaccharide exposureMouse model of pregnancyIL-8Response to bacterial LPSAssociated with chorioamnionitisFetal membrane inflammationHuman FM explantsMouse fetal membranesInduced preterm birthBacterial lipopolysaccharideMaternal-fetal interfaceDanger signalsWild-type miceIn vivo mouse modelModel of pregnancyInterleukin (IL)-8Pro-inflammatory roleResponse to bacterial lipopolysaccharideAssociated with elevated levelsResponse to LPS
2020
Viral infection dampens human fetal membrane type I interferon responses triggered by bacterial LPS
Potter JA, Tong M, Aldo P, Kwon JY, Pitruzzello M, Mor G, Abrahams VM. Viral infection dampens human fetal membrane type I interferon responses triggered by bacterial LPS. Journal Of Reproductive Immunology 2020, 140: 103126. PMID: 32289593, PMCID: PMC7299810, DOI: 10.1016/j.jri.2020.103126.Peer-Reviewed Original ResearchConceptsType I IFNsMaternal-fetal interfaceI IFNsAbility of LPSMouse fetal membranesI interferonFetal membranesViral infectionMHV-68IRF-7LPS treatmentBacterial LPSType I IFN productionLow-dose LPSPrior viral infectionΓ-herpes virusMHV-68 infectionPregnant C57BL/6 miceI IFN productionType I interferonHuman fetal membranesDose LPSInnate immune strategiesC57BL/6 miceIFN productionImmunology of the Placenta
Tong M, Abrahams VM. Immunology of the Placenta. Obstetrics And Gynecology Clinics Of North America 2020, 47: 49-63. PMID: 32008671, DOI: 10.1016/j.ogc.2019.10.006.ChaptersConceptsMaternal immune regulationMajor immune cellsMaternal-fetal interfaceInnate immune propertiesObstetric complicationsPregnancy complicationsPreterm birthPregnancy lossImmune cellsImmune regulationImmune propertiesHuman placentaPlacentaComplicationsPreeclampsiaPregnancyInfectionKey mechanismImmunology