Loss of c-KIT expression in breast cancer correlates with malignant transformation of breast epithelium and is mediated by KIT gene promoter DNA hypermethylation
Janostiak R, Vyas M, Cicek AF, Wajapeyee N, Harigopal M. Loss of c-KIT expression in breast cancer correlates with malignant transformation of breast epithelium and is mediated by KIT gene promoter DNA hypermethylation. Experimental And Molecular Pathology 2018, 105: 41-49. PMID: 29852185, DOI: 10.1016/j.yexmp.2018.05.011.Peer-Reviewed Original ResearchConceptsC-kit expressionNormal breast tissueC-kitMalignant transformationReceptor tyrosine kinasesBreast tissueBreast cancer correlatesKIT proto-oncogene receptor tyrosine kinaseBreast cancer cell linesC-kit protein expressionBreast tumor developmentProto-oncogene receptor tyrosine kinaseBreast tumor samplesCancer cell linesNormal breast epithelial tissuesTyrosine kinaseBreast epithelial tissueCancer correlatesBreast malignancyC-kit mRNABreast epitheliumBreast tumorsTransmembrane receptor tyrosine kinaseCopy number alterationsTumor samples