Discordant anti‐SARS‐CoV‐2 spike protein and RNA staining in cutaneous perniotic lesions suggests endothelial deposition of cleaved spike protein
Ko CJ, Harigopal M, Gehlhausen JR, Bosenberg M, McNiff JM, Damsky W. Discordant anti‐SARS‐CoV‐2 spike protein and RNA staining in cutaneous perniotic lesions suggests endothelial deposition of cleaved spike protein. Journal Of Cutaneous Pathology 2020, 48: 47-52. PMID: 32895985, DOI: 10.1111/cup.13866.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 spike proteinCOVID toesEccrine epitheliumEndothelial cellsSkin biopsiesSpike proteinReverse transcriptase polymerase chain reaction testingSARS-CoV-2 antibodiesPolymerase chain reaction testingSARS-CoV-2 RNAPotential pathogenetic mechanismsPositive immunohistochemical labelingSARS-CoV-2Endothelial depositionPathogenetic mechanismsImmunohistochemical stainingReaction testingImmunohistochemical labelingEccrine glandsRNA ISHImmunohistochemistrySpike RNAGold standardTissue sectionsBiopsy