2020
Enumeration and molecular characterization of circulating tumor cells as an innovative tool for companion diagnostics in breast cancer
Harigopal M, Kowalski D, Vosoughi A. Enumeration and molecular characterization of circulating tumor cells as an innovative tool for companion diagnostics in breast cancer. Expert Review Of Molecular Diagnostics 2020, 20: 815-828. PMID: 32546017, DOI: 10.1080/14737159.2020.1784009.Peer-Reviewed Original ResearchConceptsBreast cancerTumor cellsCTC enumerationCTC detectionCTC clustersMetastatic breast cancerBreast cancer patientsEnumeration of CTCsOverall survivalRisk stratificationMetastatic sitesPeripheral bloodCancer patientsCTC levelsClinical backgroundPrimary siteClinical useCancerTumor phenotypeCompanion diagnosticsTumor heterogeneityDistant sitesMolecular characterizationPatientsPredictive importance
2005
Automated Quantitative Analysis of E-Cadherin Expression in Lymph Node Metastases Is Predictive of Survival in Invasive Ductal Breast Cancer
Harigopal M, Berger AJ, Camp RL, Rimm DL, Kluger HM. Automated Quantitative Analysis of E-Cadherin Expression in Lymph Node Metastases Is Predictive of Survival in Invasive Ductal Breast Cancer. Clinical Cancer Research 2005, 11: 4083-4089. PMID: 15930343, DOI: 10.1158/1078-0432.ccr-04-2191.Peer-Reviewed Original ResearchConceptsE-cadherin expressionLymph node metastasisNodal metastasisBreast cancerImproved survivalNode metastasisTissue microarrayNode-positive breast cancerInvasive ductal breast cancerHER2/neu statusAnti-invasive roleInvasive ductal tumorsNode-positive patientsDuctal breast cancerSubset of patientsGood prognostic markerAggressive tumor behaviorStrong E-cadherin expressionHigh E-cadherin expressionCy5-conjugated antibodiesDuctal tumorsMetastatic sitesPrognostic valueTumor sizePrimary tumor