Featured Publications
The role of neurosteroids in posttraumatic stress disorder and alcohol use disorder: A review of 10 years of clinical literature and treatment implications
Peltier M, Verplaetse T, Altemus M, Zakiniaeiz Y, Ralevski E, Mineur Y, Gueorguieva R, Picciotto M, Cosgrove K, Petrakis I, McKee S. The role of neurosteroids in posttraumatic stress disorder and alcohol use disorder: A review of 10 years of clinical literature and treatment implications. Frontiers In Neuroendocrinology 2024, 73: 101119. PMID: 38184208, PMCID: PMC11185997, DOI: 10.1016/j.yfrne.2023.101119.Peer-Reviewed Original ResearchPosttraumatic stress disorderAlcohol use disorderStress disorderContext of PTSDPTSD/AUDConcurrent posttraumatic stress disorderUnderlying neurobiological mechanismsUse disordersAlcohol-related variablesNeurobiological mechanismsPTSD diagnosisTreatment developmentTreatment implicationsBody of literatureNovel interventionsClinical literatureRole of neurosteroidsDisordersTreatment outcomesYears of researchAlcohol consumptionExogenous pregnenolonePharmacological treatmentBiological variablesAllopregnanoloneThe role of sex hormones in targeting stress-induced tobacco craving, stress-reactivity, and smoking with guanfacine among women who smoke
Peltier M, McKee S. The role of sex hormones in targeting stress-induced tobacco craving, stress-reactivity, and smoking with guanfacine among women who smoke. Addiction Neuroscience 2023, 7: 100084. PMID: 37396408, PMCID: PMC10311966, DOI: 10.1016/j.addicn.2023.100084.Peer-Reviewed Original ResearchSex hormonesTobacco cravingMedication effectsMedication trialsSmoking behaviorCortisol responsePlacebo-controlled studySmoking cessation trialAd libitum periodGuanfacine's effectsCessation trialSmoking periodDrug effectsSecondary analysisGuanfacineEstradiolHormoneProgesteroneWomenCravingTrialsSex differencesContext of stressPresent studyPost-stress inductionSex Differences across Retrospective Transitions in Posttraumatic Stress and Substance Use Disorders
Peltier MR, Roberts W, Verplaetse TL, Zakiniaeiz Y, Burke C, Moore KE, McKee SA. Sex Differences across Retrospective Transitions in Posttraumatic Stress and Substance Use Disorders. Journal Of Dual Diagnosis 2021, 18: 11-20. PMID: 34965199, PMCID: PMC9086923, DOI: 10.1080/15504263.2021.2016027.Peer-Reviewed Original ResearchConceptsDrug use disordersOngoing posttraumatic stress disorderSubstance use disordersSUD/PTSDPosttraumatic stress disorderNew PTSD diagnosisImpact of sexUse disordersDiagnosis of SUDPast-year substance use disorderPTSD diagnosisConcurrent substance use disordersDiagnosis of PTSDPoor treatment outcomesNational Epidemiologic SurveyBidirectional relationshipSex-specific analysesPotential sex-specific differencesTreatment outcomesChanges in excessive alcohol use among older women across the menopausal transition: a longitudinal analysis of the Study of Women’s Health Across the Nation
Peltier MR, Verplaetse TL, Roberts W, Moore K, Burke C, Marotta PL, Phillips S, Smith PH, McKee SA. Changes in excessive alcohol use among older women across the menopausal transition: a longitudinal analysis of the Study of Women’s Health Across the Nation. Biology Of Sex Differences 2020, 11: 37. PMID: 32665024, PMCID: PMC7362573, DOI: 10.1186/s13293-020-00314-7.Peer-Reviewed Original ResearchConceptsMenopausal transitionExcessive alcohol useExcessive drinkingAlcohol useRandom effects logistic regressionAlcohol-related health consequencesSuch health problemsMethodsThe present studyPresent studyConclusionsThe present studyMenopausal transition stageSex-specific factorsHigher testosterone levelsBackgroundRecent dataEstradiol levelsPostmenopausal stageSex hormonesTestosterone levelsHormonal changesOlder womenAlcoholism criteriaAlcohol abuseAlcohol consumptionWomen's healthStudy of womenSex differences in stress-related alcohol use
Peltier MR, Verplaetse TL, Mineur YS, Petrakis IL, Cosgrove KP, Picciotto MR, McKee SA. Sex differences in stress-related alcohol use. Neurobiology Of Stress 2019, 10: 100149. PMID: 30949562, PMCID: PMC6430711, DOI: 10.1016/j.ynstr.2019.100149.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsAlcohol use disorderAlcohol useSex differencesAlcohol-induced neurodegenerationStress reactivityPresent narrative reviewAlcohol-related health consequencesEarly life stressBrain stress systemsOvarian hormonesPsychiatric comorbidityStress-related drinkingProblematic alcohol useUse disordersNarrative reviewBrain regionsBehavioral treatmentHealth consequencesStress systemAvailable evidenceRole of stressAlcohol addictionWomenLife stressExamination of sexRole of Exogenous Progesterone in the Treatment of Men and Women with Substance Use Disorders: A Narrative Review
Peltier MR, Sofuoglu M. Role of Exogenous Progesterone in the Treatment of Men and Women with Substance Use Disorders: A Narrative Review. CNS Drugs 2018, 32: 421-435. PMID: 29761343, PMCID: PMC6235727, DOI: 10.1007/s40263-018-0525-5.Peer-Reviewed Original ResearchConceptsSubstance use disordersExogenous progesteroneUse disordersTreatment of SUDsNovel pharmacological treatmentsFemale sex hormonesTreatment of menNovel pharmacological interventionsTobacco/nicotineFemale substance usersDrugs of abuseMetabolite allopregnanolonePharmacological treatmentPreliminary efficacySex hormonesPharmacological interventionsAvailable interventionsNovel treatmentsAllopregnanoloneEuphoric effectsProgesteroneNarrative reviewLiterature searchSubstance useSubstance users
2024
Gender Differences in Alcohol Use Disorder Trends from 2009-2019: An Intersectional Analysis
Verplaetse T, Carretta R, Struble C, Pittman B, Roberts W, Zakiniaeiz Y, Peltier M, McKee S. Gender Differences in Alcohol Use Disorder Trends from 2009-2019: An Intersectional Analysis. Alcohol 2024 PMID: 39579801, DOI: 10.1016/j.alcohol.2024.11.003.Peer-Reviewed Original ResearchRates of alcohol use disordersAlcohol use disorderMarital statusRates of alcohol useDrug Use and Health (NSDUHNational Survey on Drug Use and Health (NSDUHGender differencesIntersectional lensIntersectional analysisEffects of sociodemographic variablesDisorder trendsHousehold incomeNational surveyEmployment statusSociodemographic variablesAlcohol useEducation levelHeightened riskGenderLogistic regressionDemographic characteristicsEmploymentIncomeUrbanizationAdult menThe Causes and Consequences of Stigma Among Individuals Involved in the Criminal Legal System: A Systematic Review
Moore K, Phillips S, Kromash R, Siebert S, Roberts W, Peltier M, Smith M, Verplaetse T, Marotta P, Burke C, Allison G, McKee S. The Causes and Consequences of Stigma Among Individuals Involved in the Criminal Legal System: A Systematic Review. Stigma And Health 2024, 9: 224-235. PMID: 39381322, PMCID: PMC11456775, DOI: 10.1037/sah0000483.Peer-Reviewed Original ResearchAn experimental laboratory‐based minority stress paradigm for alcohol research among sexual minority women: A pilot study
Fahey K, Cservenka A, Peltier M, Mereish E, Dermody S. An experimental laboratory‐based minority stress paradigm for alcohol research among sexual minority women: A pilot study. Alcohol Clinical And Experimental Research 2024, 48: 345-361. PMID: 38149357, PMCID: PMC10922336, DOI: 10.1111/acer.15255.Peer-Reviewed Original ResearchThe criminal justice system in alcohol use treatment: a nationwide analysis of racial disparities in treatment referral and completion
Stenersen M, Peltier M, McKee S. The criminal justice system in alcohol use treatment: a nationwide analysis of racial disparities in treatment referral and completion. Alcohol And Alcoholism 2024, 59: agad092. PMID: 38266072, PMCID: PMC10807701, DOI: 10.1093/alcalc/agad092.Peer-Reviewed Original ResearchConceptsCJ systemCriminal justiceCriminal justice systemReferral to alcohol treatmentAnalysis of racial disparitiesInfluence of raceJustice systemTreatment completionNative peopleTreatment Episode Dataset-DischargeImpact of raceCommunities of colorTreatment referralAlcohol treatmentAlcohol use treatmentSubstance useRacial inequalityRacial disparitiesScholarly literatureUse treatmentAmerican Indian/Alaska Native peopleUnited StatesSeries of ANOVAsAlcohol useRace
2023
Progesterone Attenuates the Stress Response in Individuals with Alcohol Dependence and Post-Traumatic Stress Disorder – A Pilot Study
Ralevski E, Newcomb J, Pisani E, DeNegre D, Peltier M, Jane J, Yoon G, Petrakis I. Progesterone Attenuates the Stress Response in Individuals with Alcohol Dependence and Post-Traumatic Stress Disorder – A Pilot Study. Journal Of Dual Diagnosis 2023, 20: 39-51. PMID: 38147491, PMCID: PMC11214330, DOI: 10.1080/15504263.2023.2294989.Peer-Reviewed Original ResearchAlcohol use disorderStress-induced cravingCognitive performanceNegative affectNeutral scriptsStress disorderPost-traumatic stress disorderComorbid alcohol use disorderTraumatic Stress DisorderMeasures of cravingCurrent alcohol use disorderPositive emotionsTrauma scriptsPhysiological measuresCravingStress-induced symptomsTest sessionsPTSDAnxietyAffectUse disordersLaboratory sessionsCocaine dependenceAlcohol dependenceIndividualsDeveloping Researchers with Expertise in Sex as a Biological Variable through SCORE Career Enhancement Core Center Programs
Zakiniaeiz Y, Peltier M, Mineur Y, Gueorguieva R, Picciotto M, Petrakis I, Cosgrove K, McKee S. Developing Researchers with Expertise in Sex as a Biological Variable through SCORE Career Enhancement Core Center Programs. Journal Of Women's Health 2023, 32: 852-857. PMID: 37585509, PMCID: PMC10457604, DOI: 10.1089/jwh.2023.0015.Peer-Reviewed Original ResearchSex steroid hormone levels associated with dopamine D2/3 receptor availability in people who smoke cigarettes
Zakiniaeiz Y, Gueorguieva R, Peltier M, Verplaetse T, Roberts W, McKee S, Cosgrove K. Sex steroid hormone levels associated with dopamine D2/3 receptor availability in people who smoke cigarettes. Frontiers In Behavioral Neuroscience 2023, 17: 1192740. PMID: 37358969, PMCID: PMC10288103, DOI: 10.3389/fnbeh.2023.1192740.Peer-Reviewed Original ResearchSex steroid hormone levelsSteroid hormone levelsLow estradiol levelsTobacco smokingSex-matched counterpartsHormone levelsFree testosteroneEstradiol levelsAmphetamine administrationR availabilityPositron emission tomography scanPrimary addictive componentEmission tomography scanDopamine D2/3 receptor availabilityEffects of nicotineSex steroid hormonesAge-matched controlsCortical brain regionsD2/3 receptor availabilityNicotinic acetylcholine receptorsSex differencesDorsolateral prefrontal cortexDrug-taking behaviorDopaminergic actionsAddictive componentWeight change among patients engaged in medication treatment for opioid use disorder: a scoping review
Carr M, Lou R, Macdonald-Gagnon G, Peltier M, Funaro M, Martino S, Masheb R. Weight change among patients engaged in medication treatment for opioid use disorder: a scoping review. The American Journal Of Drug And Alcohol Abuse 2023, 49: 551-565. PMID: 37200510, PMCID: PMC10840392, DOI: 10.1080/00952990.2023.2207720.Peer-Reviewed Original ResearchConceptsOpioid use disorderExcess weight gainWeight gainMedication treatmentUse disordersType of MOUDBuprenorphine/naloxoneRetrospective chart reviewUse of methadoneBody mass indexModerate weight gainMOUD initiationChart reviewCohort studyOpioid useBuprenorphine/Mass indexMedication doseMethadone treatmentNonrandomized studyCase reportEthnic disparitiesPotential associationMOUDPatientsExamining the relationship of concurrent obesity and tobacco use disorder on the development of substance use disorders and psychiatric conditions: Findings from the NESARC-III
Fields L, Roberts W, Schwing I, McCoy M, Verplaetse T, Peltier M, Carretta R, Zakiniaeiz Y, Rosenheck R, McKee S. Examining the relationship of concurrent obesity and tobacco use disorder on the development of substance use disorders and psychiatric conditions: Findings from the NESARC-III. Drug And Alcohol Dependence Reports 2023, 7: 100162. PMID: 37159814, PMCID: PMC10163607, DOI: 10.1016/j.dadr.2023.100162.Peer-Reviewed Original ResearchTobacco use disorderSubstance use disordersBody mass indexUse disordersPsychiatric conditionsRisk of SUDAdditional substance use disordersSingle health conditionsRelated Conditions Wave IIIWorse health outcomesNational Epidemiological SurveyPsychiatric disorder diagnosisHarmful substance useDSM-5 criteriaConcurrent obesityComorbid obesityMass indexSUD diagnosisRisk factorsObesityComorbid diagnosesEpidemiological surveyHealth outcomesNESARC-IIIDisorder diagnosisLiquor consumption is associated with other medical conditions in females who consume alcohol
Verplaetse T, Roberts W, Peltier M, Zakiniaeiz Y, Burke C, Pittman B, McKee S. Liquor consumption is associated with other medical conditions in females who consume alcohol. Drug And Alcohol Dependence Reports 2023, 6: 100132. PMID: 36994369, PMCID: PMC10040322, DOI: 10.1016/j.dadr.2023.100132.Peer-Reviewed Original ResearchMedical conditionsOdds of painSelf-reported doctorU.S. National Epidemiologic SurveyExtreme binge drinkingNational Epidemiologic SurveyConsumption of alcoholCardiovascular conditionsClinical careBinge drinkingEpidemiologic SurveyAlcohol consumptionPoor healthRelated conditionsRisky drinkingLiquor consumptionPainAUD statusCancerMalesRespiratoryContent beveragesFemalesHigh alcohol content beverageSex
2022
Adverse Childhood Experiences and Pathways to Violent Behavior for Women and Men
Burke C, Ellis JD, Peltier MR, Roberts W, Verplaetse TL, Phillips S, Moore KE, Marotta PL, McKee SA. Adverse Childhood Experiences and Pathways to Violent Behavior for Women and Men. Journal Of Interpersonal Violence 2022, 38: 4034-4060. PMID: 35978533, PMCID: PMC9852029, DOI: 10.1177/08862605221113012.Peer-Reviewed Original ResearchConceptsAdverse childhood experiencesViolent behaviorChildhood experiencesViolent crimeFuture violenceViolenceLatent class analysisClass analysisBiological sexTypology groupsRepresentative sampleLow adversityCrimeExperienceWomenHigh riskFour-class modelMaltreatmentChildhood maltreatmentChildhood traumaRelationshipMenAdversityRiskCurrent findingsLicit and illicit drug use across trimesters in pregnant women endorsing past-year substance use: Results from National Survey on Drug Use and Health (2009–2019)
Peltier MR, Roberts W, Verplaetse TL, Burke C, Zakiniaeiz Y, Moore K, McKee SA. Licit and illicit drug use across trimesters in pregnant women endorsing past-year substance use: Results from National Survey on Drug Use and Health (2009–2019). Archives Of Women's Mental Health 2022, 25: 819-827. PMID: 35737132, PMCID: PMC9359119, DOI: 10.1007/s00737-022-01244-6.Peer-Reviewed Original ResearchConceptsPast-month substance useFirst trimesterPast-year substance usePregnant womenIllicit substance useDrug useSubstance useThird trimesterCross-sectional population-based dataSignificant public health concernTrimester of pregnancyPrescription pain medicationPopulation-based dataPerinatal substance useIllicit drug useMethodsThe present studyPublic health concernMinority of womenNational surveyLicit substance usePain medicationSimilar low ratesSecond trimesterLate trimesterLicit substancesThe association between hormonal contraceptive use and smoking, negative affect, and cessation attempts in college females
Stewart S, Peltier M, Roys M, Copeland A. The association between hormonal contraceptive use and smoking, negative affect, and cessation attempts in college females. Drug And Alcohol Dependence Reports 2022, 3: 100063. PMID: 36845992, PMCID: PMC9948877, DOI: 10.1016/j.dadr.2022.100063.Peer-Reviewed Original ResearchHormonal contraceptivesHC useCurrent smokingCessation attemptsCombination hormonal contraceptivesHormonal contraceptive useEndogenous female hormonesSmoking status interactionFemale hormonesContraceptive useQuit attemptsLower anxiety levelsNicotine useTreatment targetsPast cessation attemptsSmokingCurrent HC useProgestinsExogenous hormonesAdditional studiesWomenStatus interactionAnxiety levelsSignificant differencesSignificant main effectUsing machine learning to predict heavy drinking during outpatient alcohol treatment
Roberts W, Zhao Y, Verplaetse T, Moore KE, Peltier MR, Burke C, Zakiniaeiz Y, McKee S. Using machine learning to predict heavy drinking during outpatient alcohol treatment. Alcohol Clinical And Experimental Research 2022, 46: 657-666. PMID: 35420710, PMCID: PMC9180421, DOI: 10.1111/acer.14802.Peer-Reviewed Original ResearchConceptsAlcohol use disorderHeavy drinkingTreatment outcomesInvasive assessment methodsOutpatient AUD treatmentLast monthOutpatient alcohol treatmentMultisite clinical trialAccurate clinical predictionsHeavy alcohol useSex differencesBi-weekly sessionsAlcohol treatment outcomesPatient characteristicsClinical outcomesClinical trialsClinical dataStratified analysisEffective treatmentPsychiatric disordersUse disordersAUD treatmentSubstantial sex differencesAlcohol treatmentFirst month