2021
The Effects of Inhaled Flavors on Intravenous Nicotine
MacLean RR, Gueorguieva R, DeVito EE, Peltier MR, Parida S, Sofuoglu M. The Effects of Inhaled Flavors on Intravenous Nicotine. Experimental And Clinical Psychopharmacology 2021, 29: 615-624. PMID: 32463279, PMCID: PMC7704548, DOI: 10.1037/pha0000394.Peer-Reviewed Original ResearchConceptsCigarette smokersIntravenous nicotineE-cigarettesYoung adult cigarette smokersSubject cross-over designAdult cigarette smokersMain outcome measuresPeak heart rateHigher following administrationCross-over designAcute rewarding effectsPresent studyFollowing administrationAcute effectsOutcome measuresHeart rateRewarding effectsTobacco cigarettesSmoking urgesRewarding propertiesNicotineAddictive effectsHigher cravingMenthol flavorsThousands of flavors
2020
A prospective study of the association between rate of nicotine metabolism and alcohol use in tobacco users in the United States
Roberts W, Marotta PL, Verplaetse TL, Peltier MR, Burke C, Ramchandani VA, McKee SA. A prospective study of the association between rate of nicotine metabolism and alcohol use in tobacco users in the United States. Drug And Alcohol Dependence 2020, 216: 108210. PMID: 32805549, PMCID: PMC7609495, DOI: 10.1016/j.drugalcdep.2020.108210.Peer-Reviewed Original ResearchConceptsNicotine metabolite ratioRisk factorsAlcohol useTobacco usersNicotine metabolismTrans-3'-HydroxycotinineWave 1Biochemical risk factorsAlcohol consumption amountCurrent tobacco usersNicotine metabolism rateAssociated health outcomesSex differencesAlcohol use outcomesCigarette smokersNicotine exposureProspective studyOdds ratioTobacco useDrinking statusHealth StudyAlcohol consumptionNicotine useMetabolite ratiosHealth outcomesAssociations Between Nicotine Metabolite Ratio and Gender With Transitions in Cigarette Smoking Status and E-Cigarette Use: Findings Across Waves 1 and 2 of the Population Assessment of Tobacco and Health (PATH) Study
Verplaetse TL, Peltier MR, Roberts W, Moore KE, Pittman BP, McKee SA. Associations Between Nicotine Metabolite Ratio and Gender With Transitions in Cigarette Smoking Status and E-Cigarette Use: Findings Across Waves 1 and 2 of the Population Assessment of Tobacco and Health (PATH) Study. Nicotine & Tobacco Research 2020, 22: 1316-1321. PMID: 32152625, PMCID: PMC7364844, DOI: 10.1093/ntr/ntaa022.Peer-Reviewed Original ResearchConceptsNicotine metabolite ratioFaster nicotine metabolismHigher nicotine metabolite ratioE-cigarette useCigarette smoking statusSlower nicotine metabolismNicotine metabolismE-cigarettesSmoking statusCigarette smokingMetabolite ratiosE-cigarette use statusPopulation-based studyLongitudinal cohort studyWave 1Cigarette smoking behaviorCohort studyClinical trialsTobacco usePATH studyHealth StudySmoking behaviorEarly interventionUS populationCombustible cigarettes
2018
Motivation and Readiness for Tobacco Cessation Among Nicotine Dependent Postmenopausal Females: A Pilot Study
Peltier MR, Roys MR, Waters AF, Vinci C, Waldo KM, Stewart SA, Toups RC, Jones L, Copeland AL. Motivation and Readiness for Tobacco Cessation Among Nicotine Dependent Postmenopausal Females: A Pilot Study. Experimental And Clinical Psychopharmacology 2018, 26: 125-131. PMID: 29648860, DOI: 10.1037/pha0000191.Peer-Reviewed Original ResearchConceptsMenopausal symptom severitySymptom severityWeight concernsBrief motivational interviewingCurrent pilot studyCessation treatmentPostmenopausal femalesPostmenopausal smokersMenopausal symptomsEstrogen productionAntiestrogenic effectsConsiderable health riskB-MISomatic symptomsSmokingPilot studyMotivational interviewingBaselineSeveritySymptomsHealth risksTreatmentNegative affectCessationLow levels
2013
Nicotine Levels After IV Nicotine and Cigarette Smoking in Men
Mello NK, Peltier MR, Duncanson H. Nicotine Levels After IV Nicotine and Cigarette Smoking in Men. Experimental And Clinical Psychopharmacology 2013, 21: 188-195. PMID: 23647094, PMCID: PMC9086919, DOI: 10.1037/a0031799.Peer-Reviewed Original ResearchConceptsHigh-nicotine cigarettesCigarette smokingNicotine levelsPeak levelsTime courseNicotine-dependent menVisual analog scale ratingsPlasma nicotine levelsLow nicotine cigarettesDoses of nicotinePharmacokinetics of nicotineSimilar time courseNicotine administrationNicotine dosePlasma nicotineVAS ratingsSmokingNicotineSubjective effectsMore hrCigarettesDosesScale ratingsSubjective reportsDose
2012
Nicotine related brain activity: The influence of smoking history and blood nicotine levels, an exploratory study
Yamamoto RT, Rohan ML, Goletiani N, Olson D, Peltier M, Renshaw PF, Mello NK. Nicotine related brain activity: The influence of smoking history and blood nicotine levels, an exploratory study. Drug And Alcohol Dependence 2012, 129: 137-144. PMID: 23117126, PMCID: PMC3582808, DOI: 10.1016/j.drugalcdep.2012.10.002.Peer-Reviewed Original ResearchConceptsSerum nicotine levelsNicotine levelsIntravenous nicotinePharmacological magnetic resonance imagingBrain activityTime courseNicotine-dependent menBlood nicotine levelsGreater lifetime exposureMagnetic resonance imagingNeuro-adaptationsDistinctive activation patternsPack yearsCigarette smokingDrug exposureLifetime exposureResonance imagingDifferent visitsNicotineActivation patternsNeural activityBrain responsesSalinePhysiological measuresExposure