2021
The Effects of Inhaled Flavors on Intravenous Nicotine
MacLean RR, Gueorguieva R, DeVito EE, Peltier MR, Parida S, Sofuoglu M. The Effects of Inhaled Flavors on Intravenous Nicotine. Experimental And Clinical Psychopharmacology 2021, 29: 615-624. PMID: 32463279, PMCID: PMC7704548, DOI: 10.1037/pha0000394.Peer-Reviewed Original ResearchConceptsCigarette smokersIntravenous nicotineE-cigarettesYoung adult cigarette smokersSubject cross-over designAdult cigarette smokersMain outcome measuresPeak heart rateHigher following administrationCross-over designAcute rewarding effectsPresent studyFollowing administrationAcute effectsOutcome measuresHeart rateRewarding effectsTobacco cigarettesSmoking urgesRewarding propertiesNicotineAddictive effectsHigher cravingMenthol flavorsThousands of flavors
2013
Nicotine Levels After IV Nicotine and Cigarette Smoking in Men
Mello NK, Peltier MR, Duncanson H. Nicotine Levels After IV Nicotine and Cigarette Smoking in Men. Experimental And Clinical Psychopharmacology 2013, 21: 188-195. PMID: 23647094, PMCID: PMC9086919, DOI: 10.1037/a0031799.Peer-Reviewed Original ResearchConceptsHigh-nicotine cigarettesCigarette smokingNicotine levelsPeak levelsTime courseNicotine-dependent menVisual analog scale ratingsPlasma nicotine levelsLow nicotine cigarettesDoses of nicotinePharmacokinetics of nicotineSimilar time courseNicotine administrationNicotine dosePlasma nicotineVAS ratingsSmokingNicotineSubjective effectsMore hrCigarettesDosesScale ratingsSubjective reportsDose
2012
Nicotine related brain activity: The influence of smoking history and blood nicotine levels, an exploratory study
Yamamoto RT, Rohan ML, Goletiani N, Olson D, Peltier M, Renshaw PF, Mello NK. Nicotine related brain activity: The influence of smoking history and blood nicotine levels, an exploratory study. Drug And Alcohol Dependence 2012, 129: 137-144. PMID: 23117126, PMCID: PMC3582808, DOI: 10.1016/j.drugalcdep.2012.10.002.Peer-Reviewed Original ResearchConceptsSerum nicotine levelsNicotine levelsIntravenous nicotinePharmacological magnetic resonance imagingBrain activityTime courseNicotine-dependent menBlood nicotine levelsGreater lifetime exposureMagnetic resonance imagingNeuro-adaptationsDistinctive activation patternsPack yearsCigarette smokingDrug exposureLifetime exposureResonance imagingDifferent visitsNicotineActivation patternsNeural activityBrain responsesSalinePhysiological measuresExposure