2022
Dematiaceous fungal infections in solid organ transplantation: Systematic review and Bayesian meta‐analysis
Radcliffe C, Radcliffe AJ, Azar MM, Grant M. Dematiaceous fungal infections in solid organ transplantation: Systematic review and Bayesian meta‐analysis. Transplant Infectious Disease 2022, 24: e13819. PMID: 35253959, DOI: 10.1111/tid.13819.Peer-Reviewed Original ResearchConceptsSolid organ transplant recipientsDematiaceous fungal infectionSoft tissue infectionsFungal infectionsInfectious syndromesSystematic reviewEarly post-transplant periodCentral nervous system infectionCommon infectious syndromesPost-transplant periodNervous system infectionOrgan transplant recipientsSolid organ transplantationEnglish-language reportsInfection typeKidney recipientsLiver recipientsPediatric reportsTransplant recipientsPulmonary infectionSystem infectionTissue infectionsWorse prognosisDisseminated infectionMean ageSplenic Abscess in the New Millennium: A Descriptive, Retrospective Case Series
Radcliffe C, Tang Z, Gisriel SD, Grant M. Splenic Abscess in the New Millennium: A Descriptive, Retrospective Case Series. Open Forum Infectious Diseases 2022, 9: ofac085. PMID: 35299986, PMCID: PMC8923382, DOI: 10.1093/ofid/ofac085.Peer-Reviewed Original ResearchSplenic abscessHematogenous spreadAntimicrobial therapyLargest North American seriesHospital systemRetrospective case seriesNorth American seriesIndex hospitalizationImmunocompromised stateMedian durationClinical stabilityMedian agePercutaneous drainageCase seriesDiabetes mellitusProlonged hospitalizationRetrospective reviewMedian lengthRare infectionTreatment successHematological malignanciesPancreatic diseaseProbable casesInterventional radiologyAbscessA Difficult Microbiologic Diagnosis of Spontaneous Peritonitis
Palacios C, Grant M. A Difficult Microbiologic Diagnosis of Spontaneous Peritonitis. Infectious Diseases In Clinical Practice 2022, 30: e1124. DOI: 10.1097/ipc.0000000000001124.Peer-Reviewed Original ResearchPoor outcomes in both infection and colonization with carbapenem-resistant Enterobacterales
Howard-Anderson JR, Earley M, Komarow L, Abbo L, Anderson DJ, Gallagher JC, Grant M, Kim A, Bonomo RA, van Duin D, Muñoz-Price LS, Jacob JT. Poor outcomes in both infection and colonization with carbapenem-resistant Enterobacterales. Infection Control And Hospital Epidemiology 2022, 43: 1840-1846. PMID: 35105408, PMCID: PMC9343470, DOI: 10.1017/ice.2022.4.Peer-Reviewed Original ResearchConceptsCRE colonizationClinical outcomesCRE infectionsTract colonizationEpidemiology of patientsOutcomes of patientsProspective observational cohortCharacteristics of patientsOverall clinical outcomeShort-term acute care hospitalsUrinary tract colonizationCarbapenem-resistant EnterobacteralesRespiratory tract colonizationAcute care hospitalsDesirable clinical outcomesObservational cohortReadmission ratesSecondary outcomesPrimary outcomePoor outcomeUrinary tractRespiratory tractPatientsBetter outcomesClinical cultures
2021
Infectious Disease Images: A Remarkable, Free Resource
Radcliffe C, Grant M. Infectious Disease Images: A Remarkable, Free Resource. Open Forum Infectious Diseases 2021, 8: ofab560. PMID: 34888400, PMCID: PMC8651166, DOI: 10.1093/ofid/ofab560.Peer-Reviewed Original ResearchPott Disease: A Tale of Two Cases
Radcliffe C, Grant M. Pott Disease: A Tale of Two Cases. Pathogens 2021, 10: 1158. PMID: 34578190, PMCID: PMC8465804, DOI: 10.3390/pathogens10091158.Peer-Reviewed Case Reports and Technical NotesPott's diseaseBilateral iliopsoas abscessNew pleural effusionTuberculosis disease burdenIliopsoas abscessInfectious syndromesGreat masqueraderPleural effusionVertebral osteomyelitisHigh suspicionDisease burdenMental statusRemote historyClassic manifestationsOutpatient imagingExtensive destructionL3-L5TuberculosisDiseaseMenManagement recommendationsCase twoVasculitisAbscessOsteomyelitisBartonellosis in transplant recipients: A retrospective single center experience
Pischel L, Radcliffe C, Vilchez GA, Charifa A, Zhang XC, Grant M. Bartonellosis in transplant recipients: A retrospective single center experience. World Journal Of Transplantation 2021, 11: 244-253. PMID: 34164299, PMCID: PMC8218350, DOI: 10.5500/wjt.v11.i6.244.Peer-Reviewed Original ResearchStem cell transplant recipientsTransplant recipientsCell transplant recipientsClinical presentationDifferential diagnosisAutologous stem cell transplant recipientsHematopoietic stem cell transplant recipientsPost-transplant lymphoproliferative disorderRetrospective single-center experienceSingle-center retrospective studyRenal transplant recipientsSingle-center experienceCat-scratch diseaseCenter experienceClinical courseImmunocompromised hostLymphoproliferative disordersRetrospective studySingle institutionScratch diseaseSolid organsUnknown originDiagnostic testsRecipientsInfectionGenetic and Epidemiologic Analyses of an Outbreak of Pneumocystis jirovecii Pneumonia Among Kidney Transplant Recipients in the United States
Azar MM, Cohen E, Ma L, Cissé OH, Gan G, Deng Y, Belfield K, Asch W, Grant M, Gleeson S, Koff A, Gaston DC, Topal J, Curran S, Kulkarni S, Kovacs JA, Malinis M. Genetic and Epidemiologic Analyses of an Outbreak of Pneumocystis jirovecii Pneumonia Among Kidney Transplant Recipients in the United States. Clinical Infectious Diseases 2021, 74: 639-647. PMID: 34017984, PMCID: PMC9012955, DOI: 10.1093/cid/ciab474.Peer-Reviewed Original ResearchConceptsKidney transplant recipientsCases of PCPPneumocystis pneumoniaClinic visitsRisk factorsClinic exposureLow absolute lymphocyte countRisk of PCPAbsolute lymphocyte countFrequent clinic visitsPneumocystis jirovecii pneumoniaStrong risk factorNon-white raceCase-control analysisBelatacept groupMonthly infusionsTransplant recipientsBaseline characteristicsJirovecii pneumoniaLymphocyte countMultilocus sequence typingInterhuman transmissionRespiratory specimensUnivariate analysisEpidemiologic dataPyomyositis and Infectious Myositis: A Comprehensive, Single-Center Retrospective Study
Radcliffe C, Gisriel S, Niu YS, Peaper D, Delgado S, Grant M. Pyomyositis and Infectious Myositis: A Comprehensive, Single-Center Retrospective Study. Open Forum Infectious Diseases 2021, 8: ofab098. PMID: 33884279, PMCID: PMC8047863, DOI: 10.1093/ofid/ofab098.Peer-Reviewed Original ResearchInfectious myositisPercutaneous drainage proceduresRetrospective studyDrainage proceduresSingle-center retrospective studyThird of patientsTertiary care institutionTreatment success rateCases of pyomyositisSubjective feverMuscle painDiabetes mellitusAbscess formationCommon symptomsMedian lengthMean ageMental statusAntimicrobial therapyMost infectionsTreatment strategiesPyomyositisMyositisPathology specimensPatientsBacterial infections
2020
Nocardia veterana infections: case report and systematic review
Radcliffe C, Peaper D, Grant M. Nocardia veterana infections: case report and systematic review. New Microbes And New Infections 2020, 39: 100833. PMID: 33456780, PMCID: PMC7797559, DOI: 10.1016/j.nmni.2020.100833.Peer-Reviewed Case Reports and Technical NotesChronic cutaneous graftOral antibiotic therapySoft tissue abscessesHost diseaseCutaneous graftAntibiotic therapyPulmonary infectionCase reportDrainage proceduresEmpirical treatmentCondition warrantsSystematic reviewInfectionOpportunistic pathogenSystematic literature reviewFirst reportLiterature reviewReportAbscessRelapseReviewAzithromycinGraftTherapyNocardiaMore than Garden Variety: Massive Vegetations from Infective Endocarditis
Radcliffe C, Oen-Hsiao J, Grant M. More than Garden Variety: Massive Vegetations from Infective Endocarditis. Pathogens 2020, 9: 998. PMID: 33260314, PMCID: PMC7760194, DOI: 10.3390/pathogens9120998.Peer-Reviewed Original ResearchInfective endocarditisMassive vegetationsHospital day twoIntravenous vancomycin therapyAcute heart failureIntravenous drug abuseNative tricuspid valveAdverse eventsVancomycin therapyHeart failureSurgical interventionTricuspid valveTricuspid valvectomyValvular surfacesValvular regurgitationDay twoEndocarditisDrug abuseDramatic presentationComplicated casesSystematic literature reviewSource controlLiterature reviewValvectomyBacteremiaCOVID-19 infections and outcomes in a live registry of heart failure patients across an integrated health care system
Caraballo C, McCullough M, Fuery MA, Chouairi F, Keating C, Ravindra NG, Miller PE, Malinis M, Kashyap N, Hsiao A, Wilson FP, Curtis JP, Grant M, Velazquez EJ, Desai NR, Ahmad T. COVID-19 infections and outcomes in a live registry of heart failure patients across an integrated health care system. PLOS ONE 2020, 15: e0238829. PMID: 32997657, PMCID: PMC7526909, DOI: 10.1371/journal.pone.0238829.Peer-Reviewed Original ResearchConceptsHeart failure patientsIntegrated health care systemHeart Failure RegistryHealth care systemFailure patientsCOVID-19 infectionCare systemCOVID-19SARS-CoV-2 infectionReal-time registryRenin-angiotensin blockersRetrospective chart reviewCoronary artery diseaseRisk of deathCOVID-19 testingAngiotensin blockersMultiple comorbiditiesRespiratory failureChart reviewSymptomatic patientsArtery diseaseHeart failureComorbid conditionsPatient mortalityClinical managementA rare case of lupoid leishmaniasis defying diagnosis for a decade
Gehlhausen J, Sibindi C, Ko CJ, Grant M, Zubek A. A rare case of lupoid leishmaniasis defying diagnosis for a decade. Journal Of Cutaneous Pathology 2020, 47: 1054-1057. PMID: 32623733, DOI: 10.1111/cup.13793.Peer-Reviewed Case Reports and Technical NotesConceptsCutaneous leishmaniasisGranulomatous rosaceaPolymerase chain reactionFacial plaquesLupoid leishmaniasisMultiple medical therapiesAcid-fast bacilliExtensive travel historyStandard histopathologic examinationMedical therapyNew lesionsMultiple biopsiesRare presentationHistopathologic examinationGranulomatous diseaseTuberculoid granulomasUltimate diagnosisRare caseSustained improvementEndemic areasSpecial stainsTravel historySarcoidosisCommon diseaseRosaceaEfficacy and safety of chronic antimicrobial suppression therapy for left ventricular assist device driveline infections: A single‐center descriptive experience
Radcliffe C, Doilicho N, Niu YS, Grant M. Efficacy and safety of chronic antimicrobial suppression therapy for left ventricular assist device driveline infections: A single‐center descriptive experience. Transplant Infectious Disease 2020, 22: e13379. PMID: 32574417, DOI: 10.1111/tid.13379.Peer-Reviewed Original ResearchConceptsCAS therapyDriveline infectionSuppression therapyTreatment failureVentricular assist device driveline infectionsShort-term antimicrobial therapyExperienced treatment failureTertiary transplant centerChronic kidney diseaseCornerstone of managementContinuous-flow LVADInfectious complicationsAdverse eventsLocal debridementRetrospective reviewTransplant centersKidney diseaseStable symptomsMean ageAntimicrobial therapyCommon causePatientsTherapySuccessful outcomeInfectionOver 870 days of successful antibiotic suppression therapy for VRE‐infected left ventricular assist device
Radcliffe C, Grant M. Over 870 days of successful antibiotic suppression therapy for VRE‐infected left ventricular assist device. Journal Of Cardiac Surgery 2020, 35: 1746-1748. PMID: 32557822, DOI: 10.1111/jocs.14690.Peer-Reviewed Case Reports and Technical NotesConceptsVancomycin-resistant Enterococcus faeciumSuppression therapyVentricular assist devicePocket infectionPump exchangeAssist deviceMethicillin-sensitive Staphylococcus aureusAntibiotic suppression therapyLeft ventricular assist deviceUse of daptomycinAdvanced heart failureSymptomatic adverse eventsHeartMate II LVADLong-term suppressionMultidrug-resistant pathogensSurgical drainageAdverse eventsCommon complicationHeart failureClinical challengeInfectionDevice placementTherapyEnterococcus faeciumStaphylococcus aureusTender subcubcutaneous plaques in a patient with acute myeloid leukemia
Olamiju B, Myung P, Grant M, Leventhal JS. Tender subcubcutaneous plaques in a patient with acute myeloid leukemia. International Journal Of Dermatology 2020, 60: 311-313. PMID: 32424815, DOI: 10.1111/ijd.14943.Peer-Reviewed Case Reports and Technical NotesNontuberculous mycobacterial infections in left ventricular assist device patients
Radcliffe C, Doilicho N, Grant M. Nontuberculous mycobacterial infections in left ventricular assist device patients. Journal Of Cardiac Surgery 2020, 35: 1138-1141. PMID: 32253770, DOI: 10.1111/jocs.14530.Peer-Reviewed Case Reports and Technical NotesConceptsNontuberculous mycobacterial infectionNTM infectionMycobacterial infectionLeft ventricular assist device patientsVentricular assist device patientsRefractory heart failureContinuous-flow LVADVentricular assist deviceLVAD infectionGram-negative enteric bacteriaLVAD patientsDevice patientsHeart failureDriveline infectionDevice exchangeMost infectionsClinical challengeNegative culturesAssist deviceSystematic reviewInfectionDevice placementMycobacterium fortuitumStaphylococcal sppPatientsMolecular and clinical epidemiology of carbapenem-resistant Enterobacterales in the USA (CRACKLE-2): a prospective cohort study
van Duin D, Arias C, Komarow L, Chen L, Hanson B, Weston G, Cober E, Garner O, Jacob J, Satlin M, Fries B, Garcia-Diaz J, Doi Y, Dhar S, Kaye K, Earley M, Hujer A, Hujer K, Domitrovic T, Shropshire W, Dinh A, Manca C, Luterbach C, Wang M, Paterson D, Banerjee R, Patel R, Evans S, Hill C, Arias R, Chambers H, Fowler V, Kreiswirth B, Bonomo R, Investigators M. Molecular and clinical epidemiology of carbapenem-resistant Enterobacterales in the USA (CRACKLE-2): a prospective cohort study. The Lancet Infectious Diseases 2020, 20: 731-741. PMID: 32151332, PMCID: PMC7473597, DOI: 10.1016/s1473-3099(19)30755-8.Peer-Reviewed Original ResearchConceptsCarbapenem-resistant EnterobacteralesCarbapenemase-producing EnterobacteralesCohort studyProspective cohort studyCRE infectionsIndex culturePrimary outcomeK pneumoniaeCRE groupAdmission ratesClinical dataClinical epidemiologyClinical culturesPatientsUS hospitalsDay 107Similar outcomesDisease controlDesirability of outcomeEnterobacteralesUnique isolatesNational InstituteOutcomesWhole-genome sequencingInfectionUnder Our Very Eyes
Koff A, Malinis M, Delgado S, Grant M, Ahmad T. Under Our Very Eyes. New England Journal Of Medicine 2020, 382: 952-957. PMID: 32130818, DOI: 10.1056/nejmcps1902835.Peer-Reviewed Case Reports and Technical NotesInvasive pseudomembranous upper airway and tracheal Aspergillosis refractory to systemic antifungal therapy and serial surgical debridement in an Immunocompetent patient
Khan SN, Manur R, Brooks JS, Husson MA, Leahy K, Grant M. Invasive pseudomembranous upper airway and tracheal Aspergillosis refractory to systemic antifungal therapy and serial surgical debridement in an Immunocompetent patient. BMC Infectious Diseases 2020, 20: 13. PMID: 31906888, PMCID: PMC6945574, DOI: 10.1186/s12879-019-4744-2.Peer-Reviewed Case Reports and Technical NotesConceptsImmunocompetent patientsEndoscopic debridementLong-term antibiotic treatmentComplete disease resolutionSystemic antifungal therapySerial surgical debridementEfficacious treatment approachVoriconazole dosingRefractory symptomsSymptom controlAggressive treatmentBacterial sinusitisDisease resolutionRespiratory symptomsSurgical debridementRespiratory infectionsVoriconazole monotherapyTreatment regimensFungal infiltrationMechanical debridementUpper airwayAntibiotic treatmentAntifungal therapyDisease progressionSuch infections