2022
Poor outcomes in both infection and colonization with carbapenem-resistant Enterobacterales
Howard-Anderson JR, Earley M, Komarow L, Abbo L, Anderson DJ, Gallagher JC, Grant M, Kim A, Bonomo RA, van Duin D, Muñoz-Price LS, Jacob JT. Poor outcomes in both infection and colonization with carbapenem-resistant Enterobacterales. Infection Control And Hospital Epidemiology 2022, 43: 1840-1846. PMID: 35105408, PMCID: PMC9343470, DOI: 10.1017/ice.2022.4.Peer-Reviewed Original ResearchConceptsCRE colonizationClinical outcomesCRE infectionsTract colonizationEpidemiology of patientsOutcomes of patientsProspective observational cohortCharacteristics of patientsOverall clinical outcomeShort-term acute care hospitalsUrinary tract colonizationCarbapenem-resistant EnterobacteralesRespiratory tract colonizationAcute care hospitalsDesirable clinical outcomesObservational cohortReadmission ratesSecondary outcomesPrimary outcomePoor outcomeUrinary tractRespiratory tractPatientsBetter outcomesClinical cultures
2021
Pyomyositis and Infectious Myositis: A Comprehensive, Single-Center Retrospective Study
Radcliffe C, Gisriel S, Niu YS, Peaper D, Delgado S, Grant M. Pyomyositis and Infectious Myositis: A Comprehensive, Single-Center Retrospective Study. Open Forum Infectious Diseases 2021, 8: ofab098. PMID: 33884279, PMCID: PMC8047863, DOI: 10.1093/ofid/ofab098.Peer-Reviewed Original ResearchInfectious myositisPercutaneous drainage proceduresRetrospective studyDrainage proceduresSingle-center retrospective studyThird of patientsTertiary care institutionTreatment success rateCases of pyomyositisSubjective feverMuscle painDiabetes mellitusAbscess formationCommon symptomsMedian lengthMean ageMental statusAntimicrobial therapyMost infectionsTreatment strategiesPyomyositisMyositisPathology specimensPatientsBacterial infections
2020
Efficacy and safety of chronic antimicrobial suppression therapy for left ventricular assist device driveline infections: A single‐center descriptive experience
Radcliffe C, Doilicho N, Niu YS, Grant M. Efficacy and safety of chronic antimicrobial suppression therapy for left ventricular assist device driveline infections: A single‐center descriptive experience. Transplant Infectious Disease 2020, 22: e13379. PMID: 32574417, DOI: 10.1111/tid.13379.Peer-Reviewed Original ResearchConceptsCAS therapyDriveline infectionSuppression therapyTreatment failureVentricular assist device driveline infectionsShort-term antimicrobial therapyExperienced treatment failureTertiary transplant centerChronic kidney diseaseCornerstone of managementContinuous-flow LVADInfectious complicationsAdverse eventsLocal debridementRetrospective reviewTransplant centersKidney diseaseStable symptomsMean ageAntimicrobial therapyCommon causePatientsTherapySuccessful outcomeInfectionNontuberculous mycobacterial infections in left ventricular assist device patients
Radcliffe C, Doilicho N, Grant M. Nontuberculous mycobacterial infections in left ventricular assist device patients. Journal Of Cardiac Surgery 2020, 35: 1138-1141. PMID: 32253770, DOI: 10.1111/jocs.14530.Peer-Reviewed Case Reports and Technical NotesConceptsNontuberculous mycobacterial infectionNTM infectionMycobacterial infectionLeft ventricular assist device patientsVentricular assist device patientsRefractory heart failureContinuous-flow LVADVentricular assist deviceLVAD infectionGram-negative enteric bacteriaLVAD patientsDevice patientsHeart failureDriveline infectionDevice exchangeMost infectionsClinical challengeNegative culturesAssist deviceSystematic reviewInfectionDevice placementMycobacterium fortuitumStaphylococcal sppPatientsMolecular and clinical epidemiology of carbapenem-resistant Enterobacterales in the USA (CRACKLE-2): a prospective cohort study
van Duin D, Arias C, Komarow L, Chen L, Hanson B, Weston G, Cober E, Garner O, Jacob J, Satlin M, Fries B, Garcia-Diaz J, Doi Y, Dhar S, Kaye K, Earley M, Hujer A, Hujer K, Domitrovic T, Shropshire W, Dinh A, Manca C, Luterbach C, Wang M, Paterson D, Banerjee R, Patel R, Evans S, Hill C, Arias R, Chambers H, Fowler V, Kreiswirth B, Bonomo R, Investigators M. Molecular and clinical epidemiology of carbapenem-resistant Enterobacterales in the USA (CRACKLE-2): a prospective cohort study. The Lancet Infectious Diseases 2020, 20: 731-741. PMID: 32151332, PMCID: PMC7473597, DOI: 10.1016/s1473-3099(19)30755-8.Peer-Reviewed Original ResearchConceptsCarbapenem-resistant EnterobacteralesCarbapenemase-producing EnterobacteralesCohort studyProspective cohort studyCRE infectionsIndex culturePrimary outcomeK pneumoniaeCRE groupAdmission ratesClinical dataClinical epidemiologyClinical culturesPatientsUS hospitalsDay 107Similar outcomesDisease controlDesirability of outcomeEnterobacteralesUnique isolatesNational InstituteOutcomesWhole-genome sequencingInfectionGomori Methenamine Silver Stain on Bronchoalveolar Lavage Fluid Is Poorly Sensitive for Diagnosis of Pneumocystis jiroveci Pneumonia in HIV-Negative Immunocompromised Patients and May Lead to Missed or Delayed Diagnoses
Azar MM, Slotkin R, Abi-Raad R, Liu Y, Grant MH, Malinis MF. Gomori Methenamine Silver Stain on Bronchoalveolar Lavage Fluid Is Poorly Sensitive for Diagnosis of Pneumocystis jiroveci Pneumonia in HIV-Negative Immunocompromised Patients and May Lead to Missed or Delayed Diagnoses. Archives Of Pathology & Laboratory Medicine 2020, 144: 1003-1010. PMID: 31904277, DOI: 10.5858/arpa.2019-0394-oa.Peer-Reviewed Original ResearchHIV-negative immunocompromised patientsBronchoalveolar lavage fluidDiagnosis of PJPHIV-positive patientsImmunocompromised patientsLavage fluidGomori methenamine silver stainingPneumocystis jiroveci pneumoniaHIV-positive casesHuman immunodeficiency virusGomori methenamine silver stainMethenamine silver stainingMethenamine silver stainJiroveci pneumoniaBAL fluidHistorical gold standardRetrospective reviewImmunodeficiency virusPatientsLow burdenDiagnosisGMS stainGold standardPJPPneumonia
2017
Fatal case of cutaneous‐sparing orolaryngeal zoster in a renal transplant recipient
Helou E, Grant M, Landry M, Wu X, Morrow JS, Malinis MF. Fatal case of cutaneous‐sparing orolaryngeal zoster in a renal transplant recipient. Transplant Infectious Disease 2017, 19 PMID: 28401625, DOI: 10.1111/tid.12704.Peer-Reviewed Case Reports and Technical NotesConceptsTransplant recipientsHerpes zosterSolid organ transplant recipientsCTLA-4 inhibitorsKidney transplant recipientsRenal transplant recipientsOrgan transplant recipientsAcute rejectionSOT recipientsMucosal lesionsMeningo-encephalitisPoor outcomeFatal casesHerpesvirus infectionSignificant causeRecipientsZosterPneumonitisMorbidityPatientsLesionsInfectionMortalityCasesMycobacterium goodii endocarditis following mitral valve ring annuloplasty
Parikh RB, Grant M. Mycobacterium goodii endocarditis following mitral valve ring annuloplasty. Annals Of Clinical Microbiology And Antimicrobials 2017, 16: 14. PMID: 28327156, PMCID: PMC5361780, DOI: 10.1186/s12941-017-0190-4.Peer-Reviewed Case Reports and Technical NotesMeSH KeywordsAgedAnti-Bacterial AgentsCluster AnalysisDNA, BacterialDNA, RibosomalEchocardiography, TransesophagealEndocarditis, BacterialHeartHumansMaleMitral Valve AnnuloplastyMycobacteriumMycobacterium Infections, NontuberculousPhylogenyRadiography, ThoracicReplantationRNA, Ribosomal, 16SSequence Analysis, DNATomography, X-Ray ComputedTreatment OutcomeConceptsMitral valve ring annuloplastyInfrequent human pathogenMitral valve replacementCombination of ciprofloxacinTrimethoprim/sulfamethoxazoleDrug susceptibility testingValve replacementCase presentationWeProsthetic infectionSuccessful treatmentDifferential diagnosisRing annuloplastyMicrobiologic laboratorySusceptibility testingEndocarditisPositive rodsInfectionDiagnosisHuman pathogensGene sequencingRDNA gene sequencingAnnuloplastyPatientsMolecular techniquesInjury