2024
Medial prefrontal cortex neurotransmitter abnormalities in posttraumatic stress disorder with and without comorbidity to major depression
Swanberg K, Prinsen H, Averill C, Campos L, Kurada A, Krystal J, Petrakis I, Averill L, Rothman D, Abdallah C, Juchem C. Medial prefrontal cortex neurotransmitter abnormalities in posttraumatic stress disorder with and without comorbidity to major depression. NMR In Biomedicine 2024, 37: e5220. PMID: 39054694, DOI: 10.1002/nbm.5220.Peer-Reviewed Original ResearchPosttraumatic stress disorderMedial prefrontal cortexStress disorderPosttraumatic stress disorder patientsPosttraumatic stress disorder diagnosisChronic psychiatric conditionImpact of psychiatric comorbiditiesComorbid MDDPrefrontal cortexDepressive disorderTraumatic stressorsPsychiatric conditionsMDDPsychiatric comorbiditiesNeurotransmitter abnormalitiesConcentrations of glutamateMetabolite abnormalitiesHealthy controlsDisordersPattern of abnormalitiesParticipantsGlutamateIn vivo protonMetabolic abnormalitiesDepressionFindings of PTSD-specific deficits in default mode network strength following a mild experimental stressor
Averill C, Averill L, Akiki T, Fouda S, Krystal J, Abdallah C. Findings of PTSD-specific deficits in default mode network strength following a mild experimental stressor. NPP—Digital Psychiatry And Neuroscience 2024, 2: 9. PMID: 38919723, PMCID: PMC11197271, DOI: 10.1038/s44277-024-00011-y.Peer-Reviewed Original ResearchPosttraumatic stress disorderMajor depressive disorderConnectivity deficitsConnection strengthPrimary diagnosis of posttraumatic stress disorderExperimental stressorsDiagnosis of posttraumatic stress disorderResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingVentromedial prefrontal cortexDMN connectivity strengthStress-induced reductionEffect of groupDMN alterationsPrefrontal cortexDepressive disorderDMN connectivityStressor taskStress disorderBrain region(sAcute stressorFunctional connectivityDMNExploratory analysisDeficits366. The Effect of Early Life Trauma on Prefrontal Synaptic Strength in Major Depressive and Posttraumatic Stress Disorders
Del Motte M, Tamman A, Jiang L, Averill C, Mason G, Averill L, Abdallah C. 366. The Effect of Early Life Trauma on Prefrontal Synaptic Strength in Major Depressive and Posttraumatic Stress Disorders. Biological Psychiatry 2024, 95: s249. DOI: 10.1016/j.biopsych.2024.02.865.Peer-Reviewed Original ResearchBio-Psycho-Spiritual Perspectives on Psychedelics: Clinical and Ethical Implications.
Neitzke-Spruill L, Devenot N, Sisti D, Averill L, McGuire A. Bio-Psycho-Spiritual Perspectives on Psychedelics: Clinical and Ethical Implications. Perspectives In Biology And Medicine 2024, 67: 117-142. PMID: 38662068, DOI: 10.1353/pbm.2024.a919715.Peer-Reviewed Original Research
2023
Anti-suicidal effects of IV ketamine in a real-world setting
O'Brien B, Lee J, Kim S, Nandra G, Pannu P, Tamman A, Amarneh D, Swann A, Murphy N, Averill L, Jha M, Mathew S. Anti-suicidal effects of IV ketamine in a real-world setting. Psychiatry Research 2023, 331: 115604. PMID: 38064911, DOI: 10.1016/j.psychres.2023.115604.Peer-Reviewed Original ResearchConceptsKetamine treatmentIntravenous ketamine treatmentProportion of patientsAnti-suicidal effectsGroup of patientsTwo-week courseKetamine effectsSymptoms of suicidalityPatientsReal-world settingClinical samplesRapid improvementTrajectory groupsBaselinePossible effectivenessTreatmentScoresKetamineSymptomsGradual improvementSuicidalityDemographic variablesPresent studyHigher scoresCurrent studyCannabis-assisted psychotherapy for complex dissociative posttraumatic stress disorder: A case report
Ragnhildstveit A, Kaiyo M, Snyder M, Jackson L, Lopez A, Mayo C, Miranda A, August R, Seli P, Robison R, Averill L. Cannabis-assisted psychotherapy for complex dissociative posttraumatic stress disorder: A case report. Frontiers In Psychiatry 2023, 14: 1051542. PMID: 36846226, PMCID: PMC9947284, DOI: 10.3389/fpsyt.2023.1051542.Peer-Reviewed Original ResearchPosttraumatic stress disorderStress disorderD-PTSDIntegrative cognitive behavioral therapyCognitive behavioral therapyDissociative posttraumatic stress disorderMeeting criteriaEmotional breakthroughPsychosocial functioningBehavioral therapyDissociative subtypeOceanic boundlessnessNaturalistic settingDissociative symptomsMultidimensional InventoryPsychedelic therapyPathological dissociationEmotional sufferingEgo dissolutionSubjective effectsPsychotherapyPTSDFifth editionStatistical ManualMental disordersProspective associations of psychedelic treatment for co-occurring alcohol misuse and posttraumatic stress symptoms among United States Special Operations Forces Veterans
Armstrong S, Xin Y, Sepeda N, Polanco M, Averill L, Davis A. Prospective associations of psychedelic treatment for co-occurring alcohol misuse and posttraumatic stress symptoms among United States Special Operations Forces Veterans. Military Psychology 2023, 36: 184-191. PMID: 38377244, PMCID: PMC10880491, DOI: 10.1080/08995605.2022.2156200.Peer-Reviewed Original ResearchPost-traumatic stress disorderRisky alcohol useAlcohol useRisky drinkersProspective associationsCognitive functioning changesAlcohol misuseCo-occurring alcohol misusePosttraumatic stress symptomsFuture clinical trialsPTSD symptomsComplex traumaPsychedelic-assisted therapyStress disorderStress symptomsClinical characteristicsClinical trialsDMT treatmentPsychedelic treatmentTraditional interventionsTreatment programSignificant reductionSymptomsRespondersTreatmentRegistered clinical trials investigating ketamine and esketamine for treatment-resistant depression: A systematic review
Brendle M, Ragnhildstveit A, Slayton M, Smart L, Cunningham S, Zimmerman M, Seli P, Gaffrey M, Averill L, Robison R. Registered clinical trials investigating ketamine and esketamine for treatment-resistant depression: A systematic review. Journal Of Psychedelic Studies 2023, 6: 176-187. DOI: 10.1556/2054.2022.00234.Peer-Reviewed Original ResearchTreatment-resistant depressionMontgomery-Asberg Depression Rating ScaleDepression Rating ScaleLate-phase trialsTrial eligibilityPatient characteristicsDrug regimensClinical outcomesResults databaseRegistered trialsClinical trialsTreatment responseEsketaminePharmacological approachesPRISMA guidelinesCombination treatmentMost trialsClinical practiceElectronic registryKetamineSystematic reviewFinal reviewTherapeutic useQualitative synthesisStudy designThe potential of ketamine for posttraumatic stress disorder: a review of clinical evidence
Ragnhildstveit A, Roscoe J, Bass L, Averill C, Abdallah C, Averill L. The potential of ketamine for posttraumatic stress disorder: a review of clinical evidence. Therapeutic Advances In Psychopharmacology 2023, 13: 20451253231154125. PMID: 36895431, PMCID: PMC9989422, DOI: 10.1177/20451253231154125.Peer-Reviewed Original ResearchPosttraumatic stress disorderClinical evidenceStress disorderMethyl-d-aspartate (NMDA) receptor antagonistLow patient engagementRobust antidepressant effectsOpen-label studyOnset of actionPotential of ketamineQuality of lifeMedical comorbiditiesAntidepressant effectsChart reviewRefractory casesDisease chronicityClinical presentationRandomized trialsCase reportDevastating conditionReceptor antagonistMajor depressionPharmacological approachesPsychiatric disordersPharmacological agentsTherapeutic safety
2022
Replication of distinct trajectories of antidepressant response to intravenous ketamine
O'Brien B, Lee J, Kim S, Nandra G, Pannu P, Swann A, Murphy N, Tamman A, Amarneh D, Lijffijt M, Averill L, Mathew S. Replication of distinct trajectories of antidepressant response to intravenous ketamine. Journal Of Affective Disorders 2022, 321: 140-146. PMID: 36302492, DOI: 10.1016/j.jad.2022.10.031.Peer-Reviewed Original ResearchConceptsMajor depressive disorderKetamine infusionTreatment courseSevere depressionGroup of patientsIntravenous ketamine infusionOutpatient community clinicClinical trial samplesHigh depression groupIntravenous ketamineKetamine treatmentTreatment visitsAntidepressant responsePrior medicationMean ageCommunity clinicsDepressed patientsDepressive disorderModerate depressionRetrospective analysisInduction courseDepression groupDepressive symptomsPatientsNaturalistic samplePsychedelic treatment for co-occurring alcohol misuse and post-traumatic stress symptoms among United States Special Operations Forces Veterans
Mangini P, Averill L, Davis A. Psychedelic treatment for co-occurring alcohol misuse and post-traumatic stress symptoms among United States Special Operations Forces Veterans. Journal Of Psychedelic Studies 2022, 5: 149-155. DOI: 10.1556/2054.2021.00176.Peer-Reviewed Original ResearchPost-traumatic stress symptomsAlcohol misusePsychedelic treatmentAlcohol useCo-occurring alcohol misuseStress symptomsAnonymous internet-based surveyNovel treatment developmentRigorous longitudinal studiesUnique treatment needsPharmacologic treatmentPsychological flexibilityPsychedelic-assisted therapyInternet-based surveyTreatment needsAlcohol consumptionSymptomsClinical programsComplex sequelaeTreatment developmentCombat exposureLongitudinal studyTreatmentRetrospective reportsVeterans
2020
A Shift in Executive Connectivity Predates and Predicts Response to Treatment in Major Depressive Disorder
Nemati S, Akiki T, Ju Y, Averill C, Fouda S, Dutta A, Mckie S, Krystal J, Deakin B, Averill L, Abdallah C. A Shift in Executive Connectivity Predates and Predicts Response to Treatment in Major Depressive Disorder. Biological Psychiatry 2020, 87: s107. DOI: 10.1016/j.biopsych.2020.02.294.Peer-Reviewed Original ResearchNeurobiological Mechanisms of Ketamine: Depression, Suicide, Trauma, and Chronic Stress Pathologies
Averill L, Averill C, Abdallah C. Neurobiological Mechanisms of Ketamine: Depression, Suicide, Trauma, and Chronic Stress Pathologies. Psychiatric Annals 2020, 50: 48-53. DOI: 10.3928/00485713-20200109-02.Peer-Reviewed Original Research
2018
Sex Differences in Correlates of Risk and Resilience Associated with Military Sexual Trauma
Averill L, Smith N, Holens P, Sippel L, Bellmore A, Mota N, Sareen J, Southwick S, Pietrzak R. Sex Differences in Correlates of Risk and Resilience Associated with Military Sexual Trauma. Journal Of Aggression Maltreatment & Trauma 2018, 28: 1199-1215. DOI: 10.1080/10926771.2018.1522408.Peer-Reviewed Original ResearchMilitary sexual traumaMST survivorsDrug use disordersPTSD symptomsSexual traumaHistory of MSTUse disordersMental health treatment utilizationPTSD symptom severityLifetime traumatic eventsLifetime PTSD symptomsPhysical health outcomesPotential sex-based differencesSuicidal ideation/attemptsSex differencesRepresentative National HealthCorrelates of riskTraumatic eventsSex-based differencesResilience factorsPsychosocial correlatesUnderstanding of outcomesResilience AssociatedNational HealthTreatment utilization
2017
Neurobiology of Disaster Exposure
Averill L, Smith R, Katz C, Charney D, Southwick S. Neurobiology of Disaster Exposure. 2017, 60-75. DOI: 10.1017/9781316481424.005.Peer-Reviewed Original ResearchNon-governmental organizationsSocio-cultural issuesDisaster exposureCommunity leadersWorkplace policiesSocial responsesDisaster responseCommunity levelDisaster psychiatryDisaster respondersPublic health planningInternational expertsTerrorismHealth planningInternational referenceEarly interventionPolicyWarVictimsDecadesLeadersMedical professionalsDisastersSecond editionOrganization
2016
Ketamine’s Mechanism of Rapid Antidepressant Activity: Evidence Gleaned from Clinical Studies
Averill L, Murrough J, Abdallah C. Ketamine’s Mechanism of Rapid Antidepressant Activity: Evidence Gleaned from Clinical Studies. 2016, 99-121. DOI: 10.1007/978-3-319-42925-0_7.Peer-Reviewed Original ResearchRapid antidepressant effectsNeurobiology of depressionRapid antidepressant actionsNovel drug developmentDrug developmentKetamine's rapid antidepressant effectsRapid antidepressant activityOpen-label trialAntidepressant drug developmentKetamine's rapid antidepressant actionsTrauma-related disordersAntidepressant actionAntidepressant effectsAntidepressant medicationKetamine's mechanismSafety profileKetamine responseAntidepressant activityClinical studiesPotential biomarkersPsychotherapeutic treatmentHuman subjectsMedical SciencesDepressionNeurobiology
2015
Definitions of Abnormality
Miles S, Averill L. Definitions of Abnormality. 2015, 1-5. DOI: 10.1002/9781118625392.wbecp546.Peer-Reviewed Original Research
2009
Preliminary Evidence on the Effectiveness of Psychological Treatments Delivered at a University Counseling Center
Minami T, Davies D, Tierney S, Bettmann J, McAward S, Averill L, Huebner L, Weitzman L, Benbrook A, Serlin R, Wampold B. Preliminary Evidence on the Effectiveness of Psychological Treatments Delivered at a University Counseling Center. Journal Of Counseling Psychology 2009, 56: 309-320. DOI: 10.1037/a0015398.Peer-Reviewed Original ResearchClinical trialsTreatment effect size estimatesPoor treatment outcomesPre-post outcomesUniversity counseling centerClinical symptom measuresDifferential treatment effectsAdult major depressionProblematic substance useClinical cutoff scoresPoor outcomeOutcome Questionnaire-45.2Counseling centersEfficacy benchmarksMajor depressionTreatment outcomesTreatment efficacyTreatment dataSubstance usePsychological distressPsychological treatmentSymptom measuresCutoff scoreEffect size estimatesTreatment effects