2023
Anti-suicidal effects of IV ketamine in a real-world setting
O'Brien B, Lee J, Kim S, Nandra G, Pannu P, Tamman A, Amarneh D, Swann A, Murphy N, Averill L, Jha M, Mathew S. Anti-suicidal effects of IV ketamine in a real-world setting. Psychiatry Research 2023, 331: 115604. PMID: 38064911, DOI: 10.1016/j.psychres.2023.115604.Peer-Reviewed Original ResearchConceptsKetamine treatmentIntravenous ketamine treatmentProportion of patientsAnti-suicidal effectsGroup of patientsTwo-week courseKetamine effectsSymptoms of suicidalityPatientsReal-world settingClinical samplesRapid improvementTrajectory groupsBaselinePossible effectivenessTreatmentScoresKetamineSymptomsGradual improvementSuicidalityDemographic variablesPresent studyHigher scoresCurrent study
2022
Replication of distinct trajectories of antidepressant response to intravenous ketamine
O'Brien B, Lee J, Kim S, Nandra G, Pannu P, Swann A, Murphy N, Tamman A, Amarneh D, Lijffijt M, Averill L, Mathew S. Replication of distinct trajectories of antidepressant response to intravenous ketamine. Journal Of Affective Disorders 2022, 321: 140-146. PMID: 36302492, DOI: 10.1016/j.jad.2022.10.031.Peer-Reviewed Original ResearchConceptsMajor depressive disorderKetamine infusionTreatment courseSevere depressionGroup of patientsIntravenous ketamine infusionOutpatient community clinicClinical trial samplesHigh depression groupIntravenous ketamineKetamine treatmentTreatment visitsAntidepressant responsePrior medicationMean ageCommunity clinicsDepressed patientsDepressive disorderModerate depressionRetrospective analysisInduction courseDepression groupDepressive symptomsPatientsNaturalistic sample