2024
Medial prefrontal cortex neurotransmitter abnormalities in posttraumatic stress disorder with and without comorbidity to major depression
Swanberg K, Prinsen H, Averill C, Campos L, Kurada A, Krystal J, Petrakis I, Averill L, Rothman D, Abdallah C, Juchem C. Medial prefrontal cortex neurotransmitter abnormalities in posttraumatic stress disorder with and without comorbidity to major depression. NMR In Biomedicine 2024, 37: e5220. PMID: 39054694, DOI: 10.1002/nbm.5220.Peer-Reviewed Original ResearchPosttraumatic stress disorderMedial prefrontal cortexStress disorderPosttraumatic stress disorder patientsPosttraumatic stress disorder diagnosisChronic psychiatric conditionImpact of psychiatric comorbiditiesComorbid MDDPrefrontal cortexDepressive disorderTraumatic stressorsPsychiatric conditionsMDDPsychiatric comorbiditiesNeurotransmitter abnormalitiesConcentrations of glutamateMetabolite abnormalitiesHealthy controlsDisordersPattern of abnormalitiesParticipantsGlutamateIn vivo protonMetabolic abnormalitiesDepressionFindings of PTSD-specific deficits in default mode network strength following a mild experimental stressor
Averill C, Averill L, Akiki T, Fouda S, Krystal J, Abdallah C. Findings of PTSD-specific deficits in default mode network strength following a mild experimental stressor. NPP—Digital Psychiatry And Neuroscience 2024, 2: 9. PMID: 38919723, PMCID: PMC11197271, DOI: 10.1038/s44277-024-00011-y.Peer-Reviewed Original ResearchPosttraumatic stress disorderMajor depressive disorderConnectivity deficitsConnection strengthPrimary diagnosis of posttraumatic stress disorderExperimental stressorsDiagnosis of posttraumatic stress disorderResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingVentromedial prefrontal cortexDMN connectivity strengthStress-induced reductionEffect of groupDMN alterationsPrefrontal cortexDepressive disorderDMN connectivityStressor taskStress disorderBrain region(sAcute stressorFunctional connectivityDMNExploratory analysisDeficits366. The Effect of Early Life Trauma on Prefrontal Synaptic Strength in Major Depressive and Posttraumatic Stress Disorders
Del Motte M, Tamman A, Jiang L, Averill C, Mason G, Averill L, Abdallah C. 366. The Effect of Early Life Trauma on Prefrontal Synaptic Strength in Major Depressive and Posttraumatic Stress Disorders. Biological Psychiatry 2024, 95: s249. DOI: 10.1016/j.biopsych.2024.02.865.Peer-Reviewed Original Research
2023
Cannabis-assisted psychotherapy for complex dissociative posttraumatic stress disorder: A case report
Ragnhildstveit A, Kaiyo M, Snyder M, Jackson L, Lopez A, Mayo C, Miranda A, August R, Seli P, Robison R, Averill L. Cannabis-assisted psychotherapy for complex dissociative posttraumatic stress disorder: A case report. Frontiers In Psychiatry 2023, 14: 1051542. PMID: 36846226, PMCID: PMC9947284, DOI: 10.3389/fpsyt.2023.1051542.Peer-Reviewed Original ResearchPosttraumatic stress disorderStress disorderD-PTSDIntegrative cognitive behavioral therapyCognitive behavioral therapyDissociative posttraumatic stress disorderMeeting criteriaEmotional breakthroughPsychosocial functioningBehavioral therapyDissociative subtypeOceanic boundlessnessNaturalistic settingDissociative symptomsMultidimensional InventoryPsychedelic therapyPathological dissociationEmotional sufferingEgo dissolutionSubjective effectsPsychotherapyPTSDFifth editionStatistical ManualMental disordersProspective associations of psychedelic treatment for co-occurring alcohol misuse and posttraumatic stress symptoms among United States Special Operations Forces Veterans
Armstrong S, Xin Y, Sepeda N, Polanco M, Averill L, Davis A. Prospective associations of psychedelic treatment for co-occurring alcohol misuse and posttraumatic stress symptoms among United States Special Operations Forces Veterans. Military Psychology 2023, 36: 184-191. PMID: 38377244, PMCID: PMC10880491, DOI: 10.1080/08995605.2022.2156200.Peer-Reviewed Original ResearchPost-traumatic stress disorderRisky alcohol useAlcohol useRisky drinkersProspective associationsCognitive functioning changesAlcohol misuseCo-occurring alcohol misusePosttraumatic stress symptomsFuture clinical trialsPTSD symptomsComplex traumaPsychedelic-assisted therapyStress disorderStress symptomsClinical characteristicsClinical trialsDMT treatmentPsychedelic treatmentTraditional interventionsTreatment programSignificant reductionSymptomsRespondersTreatmentThe potential of ketamine for posttraumatic stress disorder: a review of clinical evidence
Ragnhildstveit A, Roscoe J, Bass L, Averill C, Abdallah C, Averill L. The potential of ketamine for posttraumatic stress disorder: a review of clinical evidence. Therapeutic Advances In Psychopharmacology 2023, 13: 20451253231154125. PMID: 36895431, PMCID: PMC9989422, DOI: 10.1177/20451253231154125.Peer-Reviewed Original ResearchPosttraumatic stress disorderClinical evidenceStress disorderMethyl-d-aspartate (NMDA) receptor antagonistLow patient engagementRobust antidepressant effectsOpen-label studyOnset of actionPotential of ketamineQuality of lifeMedical comorbiditiesAntidepressant effectsChart reviewRefractory casesDisease chronicityClinical presentationRandomized trialsCase reportDevastating conditionReceptor antagonistMajor depressionPharmacological approachesPsychiatric disordersPharmacological agentsTherapeutic safety