2024
Findings of PTSD-specific deficits in default mode network strength following a mild experimental stressor
Averill C, Averill L, Akiki T, Fouda S, Krystal J, Abdallah C. Findings of PTSD-specific deficits in default mode network strength following a mild experimental stressor. NPP—Digital Psychiatry And Neuroscience 2024, 2: 9. PMID: 38919723, PMCID: PMC11197271, DOI: 10.1038/s44277-024-00011-y.Peer-Reviewed Original ResearchPosttraumatic stress disorderMajor depressive disorderConnectivity deficitsConnection strengthPrimary diagnosis of posttraumatic stress disorderExperimental stressorsDiagnosis of posttraumatic stress disorderResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingVentromedial prefrontal cortexDMN connectivity strengthStress-induced reductionEffect of groupDMN alterationsPrefrontal cortexDepressive disorderDMN connectivityStressor taskStress disorderBrain region(sAcute stressorFunctional connectivityDMNExploratory analysisDeficits
2022
Replication of distinct trajectories of antidepressant response to intravenous ketamine
O'Brien B, Lee J, Kim S, Nandra G, Pannu P, Swann A, Murphy N, Tamman A, Amarneh D, Lijffijt M, Averill L, Mathew S. Replication of distinct trajectories of antidepressant response to intravenous ketamine. Journal Of Affective Disorders 2022, 321: 140-146. PMID: 36302492, DOI: 10.1016/j.jad.2022.10.031.Peer-Reviewed Original ResearchConceptsMajor depressive disorderKetamine infusionTreatment courseSevere depressionGroup of patientsIntravenous ketamine infusionOutpatient community clinicClinical trial samplesHigh depression groupIntravenous ketamineKetamine treatmentTreatment visitsAntidepressant responsePrior medicationMean ageCommunity clinicsDepressed patientsDepressive disorderModerate depressionRetrospective analysisInduction courseDepression groupDepressive symptomsPatientsNaturalistic sample
2020
A Shift in Executive Connectivity Predates and Predicts Response to Treatment in Major Depressive Disorder
Nemati S, Akiki T, Ju Y, Averill C, Fouda S, Dutta A, Mckie S, Krystal J, Deakin B, Averill L, Abdallah C. A Shift in Executive Connectivity Predates and Predicts Response to Treatment in Major Depressive Disorder. Biological Psychiatry 2020, 87: s107. DOI: 10.1016/j.biopsych.2020.02.294.Peer-Reviewed Original ResearchMajor depressive disorderDepressive disorder