A Novel Class of Small Molecule Inhibitors of Hsp90
Yi F, Regan L. A Novel Class of Small Molecule Inhibitors of Hsp90. ACS Chemical Biology 2008, 3: 645-654. PMID: 18785742, PMCID: PMC3282108, DOI: 10.1021/cb800162x.Peer-Reviewed Original ResearchConceptsGrowth-promoting proteinsChaperone heat shock protein 90Unregulated cellular proliferationHeat shock protein 90Inhibition of Hsp90Hydrolysis of ATPHuman breast cancer cell lines BT474Small molecule inhibitorsBreast cancer cell line BT474Hsp90 functionMultichaperone complexCorrect foldingAlphaScreen technologyProtein 90Hsp90Cell deathMolecule inhibitorsCell line BT474ATP analogCellular proliferationProteinNovel classCochaperonesApplicable strategyAnticancer agents