Identification of nitroxide radioprotectors.
Hahn S, Wilson L, Krishna C, Liebmann J, DeGraff W, Gamson J, Samuni A, Venzon D, Mitchell J. Identification of nitroxide radioprotectors. Radiation Research 1992, 132: 87-93. PMID: 1410280, DOI: 10.2307/3578338.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineCell SurvivalCricetinaeCyclic N-OxidesDose-Response Relationship, RadiationProtein Synthesis InhibitorsPyrrolidinesRadiation-Protective AgentsSpin LabelsTriacetoneamine-N-OxylConceptsRadiation-induced cytotoxicityTempol, a stable free radical, is a novel murine radiation protector.
Hahn S, Tochner Z, Krishna C, Glass J, Wilson L, Samuni A, Sprague M, Venzon D, Glatstein E, Mitchell J. Tempol, a stable free radical, is a novel murine radiation protector. Cancer Research 1992, 52: 1750-3. PMID: 1551104.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCyclic N-OxidesDose-Response Relationship, RadiationFemaleFree RadicalsMetabolic Clearance RateMiceMice, Inbred C3HRadiation-Protective AgentsSpin LabelsTime FactorsWhole-Body IrradiationConceptsWhole-body radiationRadiation protectorsVivo radioprotective effectsHypoxic cell radiosensitizersDose of radiationRadiation-induced cytotoxicityTempol treatmentControl micePotential therapeutic applicationsC3H miceBlood 5Hypoxanthine/xanthine oxidaseRadioprotective effectSignificant radioprotectionTempolMiceHypoxic radiosensitizationXanthine oxidaseDoseTherapeutic applicationsCellular levelCultured cellsFree radicalsRadioprotectionWhole animal