Tempol, a stable free radical, is a novel murine radiation protector.
Hahn S, Tochner Z, Krishna C, Glass J, Wilson L, Samuni A, Sprague M, Venzon D, Glatstein E, Mitchell J. Tempol, a stable free radical, is a novel murine radiation protector. Cancer Research 1992, 52: 1750-3. PMID: 1551104.Peer-Reviewed Original ResearchConceptsWhole-body radiationRadiation protectorsVivo radioprotective effectsHypoxic cell radiosensitizersDose of radiationRadiation-induced cytotoxicityTempol treatmentControl micePotential therapeutic applicationsC3H miceBlood 5Hypoxanthine/xanthine oxidaseRadioprotective effectSignificant radioprotectionTempolMiceHypoxic radiosensitizationXanthine oxidaseDoseTherapeutic applicationsCellular levelCultured cellsFree radicalsRadioprotectionWhole animal