2023
A digital health game to prevent opioid misuse and promote mental health in adolescents in school-based health settings: Protocol for the PlaySmart game randomized controlled trial
Boomer T, Hoerner L, Fernandes C, Maslar A, Aiudi S, Kyriakides T, Fiellin L. A digital health game to prevent opioid misuse and promote mental health in adolescents in school-based health settings: Protocol for the PlaySmart game randomized controlled trial. PLOS ONE 2023, 18: e0291298. PMID: 37683047, PMCID: PMC10490848, DOI: 10.1371/journal.pone.0291298.Peer-Reviewed Original ResearchConceptsMental health outcomesOpioid misuseMental healthHealth gamesHealth outcomesMeasures of depressionMental health symptomsGreater riskHelp-seeking behaviorSecondary outcome measuresCritical developmental periodOpioid use disorderPerception of riskRisk of initiationHealth symptomsSchool gradesProfessional helpMisusing opioidsPrimary outcomeDevelopmental periodAdolescentsOutcome measuresSubstance misuseUse disordersHealth settingsMultidisciplinary Strategies for Preventing Opioid Misuse and Escalation by Targeting Mental Health Symptoms and Conditions
Yule A, Fernandes C, Stormshak E, Yang Y, Shelley L, Fiellin L, Larkin K, Ridenour T, Saavedra L, Kelleher K, Feng X, Walton M, Bonar E. Multidisciplinary Strategies for Preventing Opioid Misuse and Escalation by Targeting Mental Health Symptoms and Conditions. Prevention Science 2023, 24: 77-87. PMID: 37266870, PMCID: PMC10236392, DOI: 10.1007/s11121-023-01556-8.Peer-Reviewed Original ResearchConceptsMental health conditionsOpioid use disorderOpioid misuseMental health symptomsHealth conditionsHealth symptomsMental healthSubstance useEarly substance usePrevention interventionsHigh riskUse disordersMultidisciplinary strategyPrevention effortsIdentification of youthNational InstituteSymptomsHealthInterventionRiskMisuseAssociationLeveraging the Full Continuum of Care to Prevent Opioid Use Disorder
Cance J, Adams E, D’Amico E, Palimaru A, Fernandes C, Fiellin L, Bonar E, Walton M, Komro K, Knight D, Knight K, Rao V, Youn S, Saavedra L, Ridenour T, Deeds B. Leveraging the Full Continuum of Care to Prevent Opioid Use Disorder. Prevention Science 2023, 24: 30-39. PMID: 37261635, PMCID: PMC10689575, DOI: 10.1007/s11121-023-01545-x.Peer-Reviewed Original ResearchConceptsOpioid use disorderContinuum of careUse disordersPrevention programsDisorder prevention programUnique risk profileOpioid misuseBaseline riskUnique cohortPrevention continuumRisk profileUniversal preventionYoung adultsCareOpioidsOlder adolescentsPreventionDisordersFull continuumMost substancesCohortSubstancesEvaluating the validity of game-based assessments measuring cognitive function among children and adolescents: A systematic review and meta-analysis
Aneni K, Gomati de la Vega I, Jiao M, Funaro M, Fiellin L. Evaluating the validity of game-based assessments measuring cognitive function among children and adolescents: A systematic review and meta-analysis. Progress In Brain Research 2023, 279: 1-36. PMID: 37661161, DOI: 10.1016/bs.pbr.2023.02.002.Peer-Reviewed Original ResearchMixed methods evaluation of vaping and tobacco product use prevention interventions among youth in the Florida 4-H program
Bteddini D, LeLaurin J, Chi X, Hall J, Theis R, Gurka M, Lee J, Mobley E, Khalil G, Polansky C, Kellner A, Fahnlander A, Kelder S, Fiellin L, Gutter M, Shenkman E, Salloum R. Mixed methods evaluation of vaping and tobacco product use prevention interventions among youth in the Florida 4-H program. Addictive Behaviors 2023, 141: 107637. PMID: 36753933, DOI: 10.1016/j.addbeh.2023.107637.Peer-Reviewed Original ResearchConceptsE-cigarette useE-cigarettesTobacco productsTobacco-related knowledgeRural settingsNovel prevention programFlavored tobacco productsDifferent recruitment methodsGroup intervention sessionsMixed-methods evaluationOutcome measuresPrevention interventionsControl groupTobacco knowledgePrevention programsFurther evaluationPilot studyIntervention sessionsBreathRisk perceptionInterventionRecruitment methodsScheduling of sessionsFocus group discussionsParticipants
2022
Accelerating Solutions for the Overdose Crisis: an Effectiveness-Implementation Hybrid Protocol for the HEAL Prevention Cooperative
Patel S, Cance J, Bonar E, Carter P, Dickerson D, Fiellin L, Fernandes C, Palimaru A, Boomer T, Saldana L, Singh R, Tinius E, Walton M, Youn S, Young S, Philbrick S, Lambdin B. Accelerating Solutions for the Overdose Crisis: an Effectiveness-Implementation Hybrid Protocol for the HEAL Prevention Cooperative. Prevention Science 2022, 24: 40-49. PMID: 36399222, PMCID: PMC9673891, DOI: 10.1007/s11121-022-01465-2.Peer-Reviewed Original ResearchA Pilot Randomized Controlled Trial to Evaluate a Cognitive Behavioral Videogame Intervention: empowerED
Fernandes C, Deng Y, Tran A, Hieftje K, Boomer T, Taylor C, Fiellin L. A Pilot Randomized Controlled Trial to Evaluate a Cognitive Behavioral Videogame Intervention: empowerED. Games For Health Journal 2022, 12: 42-52. PMID: 36350349, PMCID: PMC10331148, DOI: 10.1089/g4h.2021.0118.Peer-Reviewed Original ResearchConceptsCognitive reappraisalBeliefs/attitudesVideogame interventionEmotion regulation strategiesCognitive reappraisal skillsSchool climateYouth mental health needsPilot RCTHigh school settingReappraisal skillsMental health needsRegulation strategiesYouth perceptionsPreliminary effectsSchool settingsControl conditionSkill developmentHealthy developmentPreliminary efficacyPerceptionReappraisalYouthAttitudesInterventionHealth needsMethodological Strategies for Prospective Harmonization of Studies: Application to 10 Distinct Outcomes Studies of Preventive Interventions Targeting Opioid Misuse
Ridenour TA, Cruden G, Yang Y, Bonar EE, Rodriguez A, Saavedra LM, Hussong AM, Walton MA, Deeds B, Ford JL, Knight DK, Haggerty KP, Stormshak E, Kominsky TK, Ahrens KR, Woodward D, Feng X, Fiellin LE, Wilens TE, Klein DJ, Fernandes CS. Methodological Strategies for Prospective Harmonization of Studies: Application to 10 Distinct Outcomes Studies of Preventive Interventions Targeting Opioid Misuse. Prevention Science 2022, 24: 16-29. PMID: 35976525, PMCID: PMC9935745, DOI: 10.1007/s11121-022-01412-1.Peer-Reviewed Original Research
2021
Effectiveness of a Web-Based Tobacco Product use Prevention Videogame Intervention on Young Adolescents’ Beliefs and Knowledge
Hieftje KD, Fernandes CF, Lin IH, Fiellin LE. Effectiveness of a Web-Based Tobacco Product use Prevention Videogame Intervention on Young Adolescents’ Beliefs and Knowledge. Substance Abuse 2021, 42: 47-53. PMID: 31825759, DOI: 10.1080/08897077.2019.1691128.Peer-Reviewed Original ResearchConceptsTobacco product useVideogame interventionE-cigarettesElectronic cigarettesProduct useMcNemar testKnowledge questionsSingle group pre-post studyTobacco product initiationPre-post studySignificant differencesCigarette smokingProduct initiationTobacco useUse preventionHealthy beliefsPromising effectsKnowledge surveyInterventionVapingCigarettesDescriptive statisticsAdolescentsCorrect answersAge differences
2020
A quasi-experimental test of a virtual reality game prototype for adolescent E-Cigarette prevention
Weser VU, Duncan LR, Pendergrass TM, Fernandes CS, Fiellin LE, Hieftje KD. A quasi-experimental test of a virtual reality game prototype for adolescent E-Cigarette prevention. Addictive Behaviors 2020, 112: 106639. PMID: 32920455, DOI: 10.1016/j.addbeh.2020.106639.Peer-Reviewed Original ResearchConceptsSocial norm perceptionsGame prototypePerceptions of harmNorm perceptionsQuasi-experimental testPaired-samples t-testParticipants' enjoymentSocial normsPreliminary impactPerceptionEffect sizeE-cigarette preventionVirtual reality hardwarePost designAdolescentsSatisfactionVRDependent variableAttitudesHarm perceptionsE-cigarettesGameEnjoymentParticipantsGameplayIntegrated stepped alcohol treatment for patients with HIV and at-risk alcohol use: a randomized trial
Edelman EJ, Maisto SA, Hansen NB, Cutter CJ, Dziura J, Deng Y, Fiellin LE, O’Connor P, Bedimo R, Gibert CL, Marconi VC, Rimland D, Rodriguez-Barradas MC, Simberkoff MS, Tate JP, Justice AC, Bryant KJ, Fiellin DA. Integrated stepped alcohol treatment for patients with HIV and at-risk alcohol use: a randomized trial. Addiction Science & Clinical Practice 2020, 15: 28. PMID: 32727618, PMCID: PMC7388231, DOI: 10.1186/s13722-020-00200-y.Peer-Reviewed Original ResearchConceptsRisk alcohol useAlcohol useAlcohol treatmentHealth of patientsEvidence-based strategiesWeek 24HIV outcomesRoutine careTelephone boosterPhysician managementEnhancement therapyHIVPWHPatientsTrialsTarget populationTreatmentAlcohol-related researchMulti-pronged approachOutcomesParticipantsInsufficient numberTherapyPopulationMethodsIn
2019
Predictors of initiation of and retention on medications for alcohol use disorder among people living with and without HIV
Oldfield BJ, McGinnis KA, Edelman EJ, Williams EC, Gordon AJ, Akgün K, Crystal S, Fiellin LE, Gaither JR, Goulet JL, Korthuis PT, Marshall BDL, Justice AC, Bryant K, Fiellin DA, Kraemer KL. Predictors of initiation of and retention on medications for alcohol use disorder among people living with and without HIV. Journal Of Substance Use And Addiction Treatment 2019, 109: 14-22. PMID: 31856946, PMCID: PMC6982467, DOI: 10.1016/j.jsat.2019.11.002.Peer-Reviewed Original ResearchConceptsAlcohol use disorderUse disordersHIV statusUninfected individualsVeterans Aging Cohort Study (VACS) dataEvidence-based medicationsNew alcohol use disorderPrevalence of initiationMultivariable logistic regressionPredictors of initiationFacility-level predictorsCohort study dataMedication initiationPrescription fillsMultivariable analysisBlack raceTreatment gapDecreased oddsNew diagnosisPLWHOlder ageLogistic regressionMedicationsHIVSpecific subpopulationsIntegrated stepped alcohol treatment for patients with HIV and liver disease: A randomized trial
Edelman EJ, Maisto SA, Hansen NB, Cutter CJ, Dziura J, Deng Y, Fiellin LE, O'Connor PG, Bedimo R, Gibert CL, Marconi VC, Rimland D, Rodriguez-Barradas MC, Simberkoff MS, Tate JP, Justice AC, Bryant KJ, Fiellin DA. Integrated stepped alcohol treatment for patients with HIV and liver disease: A randomized trial. Journal Of Substance Use And Addiction Treatment 2019, 106: 97-106. PMID: 31540617, PMCID: PMC7244228, DOI: 10.1016/j.jsat.2019.08.007.Peer-Reviewed Original Research
2016
Hepatic Safety of Buprenorphine in HIV-Infected and Uninfected Patients With Opioid Use Disorder: The Role of HCV-Infection
Tetrault JM, Tate JP, Edelman EJ, Gordon AJ, Re V, Lim JK, Rimland D, Goulet J, Crystal S, Gaither JR, Gibert CL, Rodriguez-Barradas MC, Fiellin LE, Bryant K, Justice AC, Fiellin DA. Hepatic Safety of Buprenorphine in HIV-Infected and Uninfected Patients With Opioid Use Disorder: The Role of HCV-Infection. Journal Of Substance Use And Addiction Treatment 2016, 68: 62-67. PMID: 27431048, PMCID: PMC4976086, DOI: 10.1016/j.jsat.2016.06.002.Peer-Reviewed Original ResearchConceptsLiver enzyme elevationAlcohol use disorderUninfected patientsHepatotoxic medicationsHCV infectionUse disordersComposite endpointLiver injuryHIV/HCV co-infected patientsHCV co-infected patientsHIV/HCV statusPre-existing liver injuryCo-infected patientsCohort of HIVHepatitis C infectionHIV/HCVOpioid use disorderRisk of hepatotoxicityHCV statusHepatic safetyMedian ALTC infectionChart reviewEnzyme elevationHIV infection
2014
The Impact of Recent Cocaine Use on Plasma Levels of Methadone and Buprenorphine in Patients with and Without HIV-infection
Tetrault JM, McCance-Katz EF, Moody DE, Fiellin DA, Lruie BS, DInh AT, Fiellin LE. The Impact of Recent Cocaine Use on Plasma Levels of Methadone and Buprenorphine in Patients with and Without HIV-infection. Journal Of Substance Use And Addiction Treatment 2014, 51: 70-74. PMID: 25480096, DOI: 10.1016/j.jsat.2014.10.010.Peer-Reviewed Original ResearchConceptsRecent cocaine useHIV infectionCocaine useNorbuprenorphine concentrationsHIV statusBuprenorphine concentrationsS-methadoneAntiretroviral medication useBuprenorphine plasma concentrationsUninfected subjectsMethadone concentrationsMedication usePlasma levelsPlasma concentrationsR-methadoneCocaine effectsClinical careMethadoneBuprenorphineHIVInfectionAbstinenceSubjectsCocaineStatus
2012
Brief versus extended counseling along with buprenorphine/naloxone for HIV-infected opioid dependent patients
Tetrault JM, Moore BA, Barry DT, O'Connor PG, Schottenfeld R, Fiellin DA, Fiellin LE. Brief versus extended counseling along with buprenorphine/naloxone for HIV-infected opioid dependent patients. Journal Of Substance Use And Addiction Treatment 2012, 43: 433-439. PMID: 22938914, DOI: 10.1016/j.jsat.2012.07.011.Peer-Reviewed Original ResearchMeSH KeywordsAdultBuprenorphineBuprenorphine, Naloxone Drug CombinationCounselingDelivery of Health Care, IntegratedFeasibility StudiesFemaleFollow-Up StudiesHIV InfectionsHumansMaleMiddle AgedNaloxoneNarcotic AntagonistsOpioid-Related DisordersPsychotherapy, BriefSubstance Abuse DetectionTime FactorsTreatment OutcomeViral LoadConceptsEnhanced medical managementPhysician managementDetectable HIV viral loadHIV treatment settingsOpioid-negative urinesBuprenorphine/naloxoneHIV viral loadOpioid-dependent patientsPercentage of subjectsUntreated opioid dependenceExtended counselingHIV clinicHIV outcomesBuprenorphine/Medical managementOpioid dependenceViral loadDependent patientsExtensive counselingClinical trialsContinuous abstinenceNegative urineTreatment settingsGroup differencesCounselingPrevious Use of Alcohol, Cigarettes, and Marijuana and Subsequent Abuse of Prescription Opioids in Young Adults
Fiellin LE, Tetrault JM, Becker WC, Fiellin DA, Hoff RA. Previous Use of Alcohol, Cigarettes, and Marijuana and Subsequent Abuse of Prescription Opioids in Young Adults. Journal Of Adolescent Health 2012, 52: 158-163. PMID: 23332479, PMCID: PMC3552239, DOI: 10.1016/j.jadohealth.2012.06.010.Peer-Reviewed Original ResearchConceptsPrescription opioidsPrevious marijuana usePrevious substance usePrevious alcoholMarijuana useSubsequent abuseYoung womenSubstance useYoung adulthoodCommunity-dwelling individualsLogistic regression analysisCurrent abusePrevious alcohol useClinical dataOpioidsDrug useSubstance abuseAlcohol useCigarettesPrevention effortsPrevious useYoung adultsYoung individualsYoung menYear oldsCombining Rapid HIV Testing and a Brief Alcohol Intervention in Young Unhealthy Drinkers in the Emergency Department: A Pilot Study
Edelman EJ, Dinh A, Radulescu R, Lurie B, D'Onofrio G, Tetrault JM, Fiellin DA, Fiellin LE. Combining Rapid HIV Testing and a Brief Alcohol Intervention in Young Unhealthy Drinkers in the Emergency Department: A Pilot Study. The American Journal Of Drug And Alcohol Abuse 2012, 38: 539-543. PMID: 22794939, PMCID: PMC3522092, DOI: 10.3109/00952990.2012.701359.Peer-Reviewed Original ResearchConceptsSexual risk reduction counselingSexual risk behaviorsRisk reduction counselingRapid HIV testingEmergency departmentRisk behaviorsReduction counselingHIV testingAlcohol useUnhealthy drinkersAlcohol consumptionMean age 26 yearsAverage weekly drinksImportant preventive servicesAlcohol Use Disorders Identification Test (AUDIT) scoresUnknown HIV statusRapid HIV testsUnhealthy alcohol useAge 26 yearsBrief alcohol interventionHIV testHIV statusRegular doctorPreventive servicesRisk populations
2008
The impact of alcohol use on depressive symptoms in human immunodeficiency virus‐infected patients†
Sullivan LE, Saitz R, Cheng DM, Libman H, Nunes D, Samet JH. The impact of alcohol use on depressive symptoms in human immunodeficiency virus‐infected patients†. Addiction 2008, 103: 1461-1467. PMID: 18637000, PMCID: PMC2661114, DOI: 10.1111/j.1360-0443.2008.02245.x.Peer-Reviewed Original ResearchConceptsComposite International Diagnostic InterviewCurrent alcohol dependenceDepressive symptomsAlcohol dependenceAlcohol useHigher CES-D scoresEpidemiologic Studies Depression ScaleHuman immunodeficiency virusPast alcohol problemsCES-D scoresAlcohol problemsMore depressive symptomsMixed-effects regression modelsHeavy alcohol usePrimary outcomeImmunodeficiency virusPotential confoundersHuman immunodeficiencyDepression ScaleUnadjusted modelsDiagnostic InterviewSymptomsCalendar-based methodsMonths consumptionHeavy drinking