Control of DNA Replication and Chromosome Ploidy by Geminin and Cyclin A
Mihaylov IS, Kondo T, Jones L, Ryzhikov S, Tanaka J, Zheng J, Higa LA, Minamino N, Cooley L, Zhang H. Control of DNA Replication and Chromosome Ploidy by Geminin and Cyclin A. Molecular And Cellular Biology 2002, 22: 1868-1880. PMID: 11865064, PMCID: PMC135598, DOI: 10.1128/mcb.22.6.1868-1880.2002.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell Cycle ProteinsCell LineCell NucleusCheckpoint Kinase 1ChromosomesCyclin ACyclin BDNADNA ReplicationDNA-Binding ProteinsDown-RegulationDrosophilaDrosophila ProteinsFlow CytometryGene SilencingMolecular Sequence DataPloidiesProtein Kinase InhibitorsProtein KinasesRNA, Double-StrandedSequence Homology, Amino AcidConceptsDNA replicationGeminin deficiencyGenome stabilityCyclin ASingle giant nucleusGiant nucleiCell cycle arrestDrosophila homologueDrosophila cellsGenome instabilityCheckpoint controlChromosome ploidyReplication factorsOverreplicationCyclin BGemininDouble knockoutCycle arrestRapid downregulationDNA contentGenomeSilencingEffect of cyclinHomologuesCyclin