2014
A Regulatory Network of Drosophila Germline Stem Cell Self-Renewal
Yan D, Neumüller RA, Buckner M, Ayers K, Li H, Hu Y, Yang-Zhou D, Pan L, Wang X, Kelley C, Vinayagam A, Binari R, Randklev S, Perkins LA, Xie T, Cooley L, Perrimon N. A Regulatory Network of Drosophila Germline Stem Cell Self-Renewal. Developmental Cell 2014, 28: 459-473. PMID: 24576427, PMCID: PMC3998650, DOI: 10.1016/j.devcel.2014.01.020.Peer-Reviewed Original ResearchConceptsGermline stem cellsSelf-renewal factorsDrosophila female germline stem cellsStem cellsDifferent stem cell lineagesLarge-scale RNAi screenFemale germline stem cellsLoss of Set1Stem Cell Self-RenewalSpecific genetic networksHistone methyltransferase Set1Stem cell identityCell fate decisionsStem cell lineagesCell Self-RenewalSelf-renewal genesRNAi screenDistinct fatesFate decisionsGSC maintenanceCell identityCell fateRegulatory networksGenetic networksNeural stem cells
1999
Ecdysone response genes govern egg chamber development during mid-oogenesis in Drosophila
Buszczak M, Freeman M, Carlson J, Bender M, Cooley L, Segraves W. Ecdysone response genes govern egg chamber development during mid-oogenesis in Drosophila. Development 1999, 126: 4581-4589. PMID: 10498692, DOI: 10.1242/dev.126.20.4581.Peer-Reviewed Original ResearchConceptsEgg chamber developmentGermline clonesResponse genesGene expressionDorsal follicle cell fatesEgg chamber maturationMutant egg chambersFollicle cell fatesSteroid hormone ecdysoneEcdysone response genesProgression of oogenesisTemperature-sensitive mutationStage-specific mannerTemporal expression profilesEarly response genesChamber developmentEcdysone responsivenessChamber maturationHormone ecdysoneGenetic hierarchyEcR expressionDrosophila melanogasterEgg chambersCell fateEarly gene expression